Exploring topical atorvastatin hyalurosomal gel as an adjuvant for reducing systemic corticosteroid dosage: a randomized clinical trial in severe oral lichen planus patients.

Oral lichen planus (OLP) is a chronic inflammatory disorder with limited topical treatment options and long-term corticosteroid dependency. This study investigates a novel atorvastatin-loaded hyalurosomal gel (ATV-Hyalugel) as a topical adjuvant to reduce systemic corticosteroid use in severe OLP. The objective of the study is to develop, optimize, characterize ATV-Hyalugel and evaluate its clinical efficacy in a randomized controlled clinical trial.

Unlocking Therapeutic Potential of Novel Thieno-Oxazepine Hybrids as Multi-Target Inhibitors of AChE/BChE and Evaluation Against Alzheimer's Disease: In Vivo, In Vitro, Histopathological, and Docking Studies.

Alzheimer's disease (AD) is largely linked with oxidative stress, the accumulation of amyloid- plaques, and hyperphosphorylated -protein aggregation. Alterations in dopaminergic and serotonergic neurotransmission have also been implicated in various AD-related symptoms. : To explore new therapeutic agents, a series of bicyclic and tricyclic thieno-oxazepine derivatives were synthesized as potential acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors.

Ramadan fasting in smokers with primary headache disorders: Impact of nicotine dependence on headache frequency and severity.

Background: Nicotine withdrawal has not been studied before as a contributing factor for headache exacerbations during Ramadan. Therefore, we aimed to explore the impact of smoking status and nicotine dependence on the frequency and severity of primary headache disorders during fasting.

Methods: This prospective cohort study with pre-post comparisons was conducted on male smokers and nonsmokers with primary headache disorders.

Enhanced meropenem activity and stability following load in Polyvinyl alcohol nanofiber scaffolds with sitagliptin as quorum sensing inhibitor on Pseudomonas aeruginosa.

Background: The increasing resistance of bacteria to conventional antibiotics poses a significant health challenge. Innovative strategies, such as combining antibiotics with agents like quorum sensing inhibitors (QSIs), have been developed to combat this issue. QSIs enhance antibiotic efficacy without inhibiting bacterial growth, minimizing the risk of resistance.

Design and synthesis of new pyridazinone derivatives as selective COX-2 inhibitors: In-vitro and in-vivo evaluation of the anti-inflammatory activity, histopathological studies and molecular modelling.

New pyridazinone derivatives 3a-d, 4a, 4b, and 5a-f were synthesized and tested for in-vitro inhibition of human COX-1 and COX-2. Compounds 5a and 5f showed strong COX-2 inhibition (IC = 0.77 and 1.

Acceptance of AI-Powered Chatbots Among Physiotherapy Students: International Cross-Sectional Study.

Background: Artificial intelligence-powered chatbots (AI-PCs) are increasingly integrated into educational settings, including health care disciplines. Despite their potential to enhance learning, limited research has investigated physiotherapy (PT) students' acceptance of this technology.

Objective: This study aims to assess undergraduate PT students' acceptance of AI-PCs and to identify personal, academic, and technological factors influencing their acceptance.

Pyridazine and Pyridazinone in Medicinal Chemistry: Synthesis and Antiinflammatory Pathways Targeting TxA2, TNF-α, and IL-6.

Inflammation is a fundamental biological reaction to harmful stimuli, which is crucial in the initiation and advancement of different diseases, including rheumatoid arthritis, cardiovascular conditions, neurological disorders such as Alzheimer's and Parkinson's, and multiple cancer types. Chronic inflammation, in particular, contributes to irreversible tissue damage and the progression of disease. Thus, the suppression of key inflammatory mediators has become a promising therapeutic approach.

Targeting α‑Klotho Protein by Agmatine and Pioglitazone Is a New Avenue against Diabetic Nephropathy.

Diabetic nephropathy (DN) is a common microvascular complication of diabetes mellitus (DM). Several mechanisms have been proposed for DN pathogenesis; however, it remains a progressive risk for DM patients. For the first time, the current study aimed to investigate the nephroprotective effects of agmatine and pioglitazone through modulating α-klotho, anti-ERS, anti-inflammatory, and antipyroptotic properties in ameliorating DN.

Plummer-Vinson Syndrome: A Retrospective Multicenter Study.

Background: Plummer-Vinson syndrome (PVS) is a rare disorder characterized by post-cricoid dysphagia, iron deficiency anemia (IDA), and upper esophageal web formation. Despite its clinical significance and potential progression to esophageal squamous cell carcinoma (SCC), data on PVS remain limited. This study aims to analyze the demographic, clinical, imaging characteristics, and treatment outcomes of PVS across multiple centers.

Carbon dot based molecularly imprinted polymer for selective fluorometric determination of tetracycline and metronidazole in pharmaceuticals and human plasma.

A highly sensitive, selective, and rapid spectrofluorometric method has been developed using fluorescence sensors. This method is based on the highly fluorescent graphene quantum dots coated with silica molecularly imprinted polymers (GQDs-SMIPs) for the determination of tetracycline HCl (TET) and metronidazole (MET). Upon excitation of the GQDs-SMIPs at 260.

Effect of lifestyle changes on liver enzymes, triglycerides, sex hormones, and daytime sleepiness in polycystic ovarian syndrome women with obstructive sleep apnea and fatty liver - a randomized controlled trial.

Introduction: Lifestyle changes are one of the main therapeutic approaches for women with polycystic ovarian syndrome (PCOS), non-alcoholic fatty liver disease (NAFLD), and obstructive sleep apnea (OSA). This 8-week study aimed to assess the effect of lifestyle modifications on liver enzymes, triglycerides (TG), sex hormones, and daytime sleepiness in PCOS women with NAFLD and mild and moderate OSA.

Material And Methods: This study included 40 women.

Therapeutic impact of vildagliptin vs. gliclazide on insulin resistance and advanced glycated end product levels in newly diagnosed Egyptian diabetics: a randomized controlled trial.

Background: The present study aimed to investigate the effects of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on insulin resistance and weight reduction through advanced glycation end-product modulation in patients newly diagnosed with type 2 diabetes mellitus.

Methods: This study was designed as a 12-week, randomized, controlled, parallel trial. A total of 120 patients with type 2 diabetes were selected and divided into two distinct groups: group I, patients who received gliclazide in combination with metformin, and group II, patients who received vildagliptin in combination with metformin.

Stellate Ganglion Block for Management of Nicolau's Syndrome Following Intravenous Ibuprofen Injection: a Case Report and Literature Review.

Purpose Of The Review: Nicolau's syndrome (NS) is a rare but serious drug reaction that occurs after administration of many drugs through various routes, with a broad spectrum of manifestations ranging from severe pain up to skin necrosis. In this review, we reported a case of advanced-grade NS following intravenous injection of ibuprofen. Moreover, we reviewed the existing knowledge and current practice to present in-depth any possible pathogeneses involved in this condition and highlight the specific pharmacological properties of the offending drugs that may play a role in the development of this syndrome.

The remineralizing ability of self-assembling peptide P11-4, 2% arginine enriched sodium fluoride and functionalized tri calcium phosphate fluoride varnishes in treatment of white spot lesions - a randomized controlled trial.

Background: White spot lesions (WSLs) is a caries lesion distinguished by white opacity due to subsurface enamel demineralization. These lesions resulting from a disparity between detrimental and protective factors and can continue to demineralize if untreated. Early diagnosis and remineralization can reverse WSLs, supporting minimally invasive dental care.

Fostering a safe horizon: Nursing organizational culture as a mediator between medication safety climate and reporting intentions for high-alert medication errors among pediatric nursing care.

Introduction: Medication errors in pediatric care, especially involving high-alert medications, pose significant risks. Nurses' reluctance to report such errors is influenced by organizational culture, fear of blame, and ineffective reporting systems. A positive medication safety climate and supportive organizational culture are essential in promoting error-reporting behaviors.

Bridging the gap: the mediating role of self-efficacy in the impact of workload on core competencies among pediatric nurses.

Background: Pediatric nurses operate in high-stakes environments characterized by emotional, cognitive, and physical demands. Excessive workload can undermine nurses' ability to perform effectively, particularly when compounded by low self-efficacy. Core competencies such as clinical judgment, evidence-based practice, and communication are essential to pediatric nursing performance and are susceptible to the influence of psychological and environmental stressors.

Innovate sodium alginate microneedle patches integrated with soft lidocaine invasomes: advanced strategies for oral ulcerative mucositis treatment via TNF-α/NF-κB pathways.

Oral ulcerative mucositis (OUM) is a common painful disease that affects oral functions, such as eating or speaking leading to a low quality of life. This study aims to develop a novel strategy for relieving pain associated with OUM by using local anesthetics. Here, a hybrid dissolving microneedle patch integrated with lidocaine (Lido)-encapsulated invasomes (modified liposomes containing terpenes as penetration enhancers) depots are introduced for sustained Lido delivery, reduced dosing frequency, and improved patient compliance.

Topical application of standardized capsicum and rosemary extracts promotes hair growth in testosterone induced alopecia in Wistar rats: Histological and morphometric evaluation.

Introduction: Alopecia, a common condition causing hair loss, leads to decreased self-esteem worldwide. Natural extracts such as rosemary (Rosmarinus officinalis L.) and capsicum (Capsicum annuum L.

Influence of Electro-Acupuncture on Diplopia in Patients With Oculomotor and Abducens Nerves Palsy.

Background: Diplopia (DP) can have a significant negative impact on one's quality of life, many clinical investigations lend credence to the notion that acupuncture could be used to treat DP symptoms, randomized controlled trials are lacking, and only clinical observational studies have assessed the effectiveness of acupuncture in managing DP.

Purpose: To examine the influence of electro-acupuncture on diplopia in patients with oculomotor and abducens nerve palsy.

Methods: Forty eyes diagnosed with diplopia were randomly classified into study group (A) that received electro acupuncture therapy and standard prophylactic medications for 4 weeks at points selected for treating double vision, and control group (B) who received standard prophylactic medications only.

Novel furo[2,3-]pyrimidine derivatives as PI3K/AKT dual inhibitors: design, synthesis, biological evaluation, and molecular dynamics simulation.

The current study aimed to synthesize a series of innovative improved anticancer chemical entities by combining the unique advantages of 1,3,4-thiadiazole as an established anticancer pharmacophore with the furopyrimidine scaffold which is a key component of many reported cytotoxic agents. Sixteen furopyrimidine derivatives were designed and evaluated by several biological tests including antiproliferative activity against 60 human cancer cell lines, measurement of GI, TGI, and LC values, MTT and selectivity index (SI) calculation, enzymatic PI3Kα/β and AKT inhibitory assay, cell cycle analysis and apoptosis evaluation. The results indicated that the designed compound 10b revealed potent anticancer activity with a mean GI of 108.

Therapeutic Role of l-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice.

Memory decline is a prominent hallmark of Alzheimer's disease (AD). Scopolamine-induced amnesia is a pharmacological paradigm in AD research to model these cognitive insults. AD represents the most prevalent type of dementia among the elderly, depicted by impaired cognition and memory.

Dissolving Microneedles Containing Lactoferrin Nanosuspension for Enhancement of Antimicrobial and Anti-Inflammatory Effects in the Treatment of Dry Eye Disease.

Dry eye disease (DED), also known as "keratoconjunctivitis sicca", is a common chronic ocular surface disease accompanied by inflammation and diminished tear production. Bovine Lactoferrin (BLF), a multi-functional iron-binding glycoprotein found in tears, decreased significantly in patients with DED, used for the treatment of dry eye, conjunctivitis, and ocular inflammation. BLF has limited therapeutic efficacy due to poor ocular bioavailability.

Augmented Marshmallow Extract Lipid Nanoparticles with Clove Oil Embedded in Collagen Sponge for Ultimate Antimicrobial Healing of Diabetic Mouth Ulcer.

: Diabetic mouth ulcers are a pathological condition of the oral mucosa leading to increases in susceptibility to infection and prolonged wound healing time. Still, there is a lack of natural formulations for treating this condition. Our principal objective was to formulate solid lipid nanoparticles (SLNs) that contained (marshmallow) (M.

Flexible mini-percutaneous nephrolithotomy versus retrograde intra-renal surgery in the management of renal stones: a randomized controlled trial.

Purpose: To assess the safety, efficacy, and cost-effectiveness of flexible mini-percutaneous nephrolithotomy (F-mPCNL) in managing nephrolithiasis compared to retrograde intrarenal surgery (RIRS).

Methods: 130 adult patients with renal stones (1.5-3 cm) were randomized to F-mPCNL or RIRS.

Green chromatographic approach to determine methocarbamol, aspirin and their related impurities in their combined pharmaceutical formulation and human plasma: with computational evaluation.

Nowadays, one of the main objectives is to protect the environment and reduce the adverse impacts of chemicals on it. One of the most difficult issues for researchers is determining the efficiency and quality of the suggested approach in terms of environmental and human safety. The present research presents advanced, accurate, green high-performance liquid chromatographic method (HPLC) to estimate a combination of methocarbamol (MET) and aspirin (ASP) as well as their related impurities, guaifenesin (GUF) and salicylic acid (SA), respectively, with low retention time and ideal separation.