Boosting biodiesel production from WCO utilizing marble waste powder as precursor for CaO/KCO nanocatalyst at low temperature RSM optimization.

This study aims to valorize hazardous industrial marble machining and shaping waste powder as a precursor to prepare a heterogeneous nano-catalyst (CaO/KCO) employing the wet-impregnation method for producing biodiesel the transesterification of waste cooking oil (WCO). Surface and morphological characterization of the thus-prepared nano-catalyst has been performed employing various analytical tools, , XRD, BET, CO-TPD, FT-IR, HR-TEM, and FE-SEM & mapping EDX. The impact of calcination treatment on the catalytic performance is investigated together with the weight percentage (wt%) of CaO compared to KCO.

Eco-Friendly Spectrophotometric Methods for Resolving the Spectral Inference of Benzalkonium Chloride During Alcaftadine and Ketorolac Tromethamine Quantification.

The pharmaceutical industry has recently introduced a new combination of eye drop containing alcaftadine (ALF) and ketorolac tromethamine (KTC) utilized in managing allergic conjunctivitis. This new formulation elevates the necessity for developing sensitive, reliable, rapid and simple spectrophotometric methods to accurately quantify ALF and KTC in their dosage form with full consideration of its preservative benzalkonium chloride. In this study, three simple green spectrophotometric methods were developed to simultaneously determine ALF, KTC, and benzalkonium chloride in their ternary combinations without requiring preliminary separation steps.

Amniotic membrane-encapsulated chitosan-lecithin nanoparticles promote the regenerative potential of mesenchymal stromal cells and fibroblasts.

The human amniotic membrane (hAM) is a promising therapeutic source in regenerative medicine due to its rich content of growth factors and bioactive molecules. Its clinical application, however, has remained limited by challenges in controlled delivery and compositional complexity. To address these issues, we developed a nanoparticle-based formulation (NF-hAM) to encapsulate hAM proteins and enhance their targeted delivery to mesenchymal stem cells (MSCs) and fibroblasts.

Novel furo[2,3-]pyrimidine derivatives as PI3K/AKT dual inhibitors: design, synthesis, biological evaluation, and molecular dynamics simulation.

The current study aimed to synthesize a series of innovative improved anticancer chemical entities by combining the unique advantages of 1,3,4-thiadiazole as an established anticancer pharmacophore with the furopyrimidine scaffold which is a key component of many reported cytotoxic agents. Sixteen furopyrimidine derivatives were designed and evaluated by several biological tests including antiproliferative activity against 60 human cancer cell lines, measurement of GI, TGI, and LC values, MTT and selectivity index (SI) calculation, enzymatic PI3Kα/β and AKT inhibitory assay, cell cycle analysis and apoptosis evaluation. The results indicated that the designed compound 10b revealed potent anticancer activity with a mean GI of 108.

Linn. Extract as an Innovative Strategy to Regulate Biomarkers for Ovarian Hyperthecosis via Circular RNA (hsa-circ-0001577): Evidence From Biochemical, Metabolomics, Histological, and Phytochemical Profiling.

species, including Linn, are well-known vegetables whose leaves, shoots, fragile stems, and grains are commonly utilized as herbs in soups or sauces, aside from traditional uses to treat a wide range of illnesses. Ovarian hyperthecosis is a common syndrome associated with metabolomics and endocrinology that lowers female fertility. The investigation of novel biomarkers and targeted therapies for the detection and treatment of ovarian hyperthecosis is of interest.

Prevalence of Work-Related Musculoskeletal Disorders and Associated Factors Among Doctor of Physical Therapy in Syria: A Cross-Sectional Study.

Background And Aims: Recognizing the factors contributing to work-related musculoskeletal disorders (WMSDs) is vital for advancing well-being and maintaining a safe working environment, particularly for Doctor of Physical Therapists (DPTs). This study aims to explore the potential contributors to WMSDs among DPTs in Syria, where research on this issue is limited.

Methods: A self-administered online survey evaluating WMSDs was distributed to DPTs.

Exploring Glucagon-Like Peptide-1 Receptor Agonists Usage Among Non-Diabetic Healthcare Providers: A Cross-Sectional Multi-Country Study.

Background And Aim: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were initially developed for type 2 diabetes but have gained widespread use for weight management, including among non-diabetic individuals. This study aimed to estimate the prevalence of GLP-1RA use, describe usage patterns, and explore healthcare providers' (HCPs) perceptions of their efficacy and safety.

Methods: A cross-sectional study was conducted among 657 HCPs from 10 countries using a structured online survey between September and December 2023.

Evaluation of the antimicrobial activity of chitosan- and curcumin-capped copper oxide nanostructures against multi-drug-resistant microorganisms.

The emergence of multi-drug-resistant microorganisms presents a serious threat to infection control, for which new antimicrobial strategies are urgently needed. Herein, the antimicrobial activities of copper oxide nanoparticles capped with curcumin (Cur-CuO NPs) and copper oxide nanoparticles capped with chitosan (CS-CuO NPs) were investigated. They were prepared the co-precipitation method.

The Phenolic Signature of Fruits and Leaves Modulates TRPV1 and TRPA1 Transient Receptor Potential Channels: A Metabolomics, In Vitro, and In Silico Study.

Although (strawberry guava, Myrtaceae) is known for its anti-inflammatory, antioxidant, antimicrobial, and antidiabetic properties, its phytochemical profile and associated bioactivities remain largely underexplored. This study employed UHPLC-QTOF-HRMS for untargeted phenolic profiling of leaf and fruit extracts from , followed by semi-quantification of phenolic subclasses and multivariate data analysis. Four hundred sixty-nine metabolites, including various phenolic subclasses-predominantly flavonoids and phenolic acids were- identified and annotated.

Donepezil-based rational design of -substituted quinazolinthioacetamide candidates as potential acetylcholine esterase inhibitors for the treatment of Alzheimer's disease: and studies.

Alzheimer's disease (AD) stands as one of the most outstanding progressive neurodegenerative disorders. Obviously, acetylcholine esterase (AChE) is the primary enzyme responsible for breaking down acetylcholine (ACh) with a much more prominent effect than butyrylcholine esterase (BuChE). Hence, novel quinazoline derivatives (3a-p) were designed and synthesized as AChE inhibitors for AD treatment.

Association of methylenetetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, and CYP3A4 A290G gene polymorphisms with clinical outcomes of HLA-matched sibling allogeneic hematopoietic cell transplantation in an Egyptian patient/donor cohort.

The impact of non-HLA drug-metabolizing gene polymorphisms on post-transplant outcomes is well recognized. We aimed to evaluate the impact of 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T and A1982C and CYP3A4 A290G polymorphisms on the outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) from fully matched siblings. Using PCR-RFLP and according to DNA availability, MTHFR and CYP3A4-V polymorphisms were evaluated.

Dual EGFR and telomerase inhibitory potential of new triazole tethered Schiff bases endowed with apoptosis: design, synthesis, and biological assessments.

Many cancers have displayed resistance to chemotherapeutic drugs over the past few decades. EGFR has emerged as a leading target for cancer therapy inhibiting tumor angiogenesis. Besides, studies strongly suggest that blocking telomerase activity could be an effective way to control the growth of certain cancer cells.

Anxiety and Depression Among Adults and Children With Celiac Disease: A Meta-Analysis of Different Psychiatry Scales.

Background: Celiac disease (CD) is an autoimmune disorder in which genetically susceptible individuals cannot digest gluten (wheat) and its homologs such as Scalin (rye) and Hordein (barley).

Aim: This systematic review and meta-analysis aimed to investigate the measures of associations between CD and psychiatric disorders, specifically anxiety and depression, and explore the relationship between adherence to a Gluten-Free Diet (GFD) and the psychiatric aspects of the disease.

Methods: We searched PubMed, Scopus and Web of Science for articles investigating anxiety and depression in CD patients.

Coexistence Between Antiphospholipid Syndrome and Protein S Deficiency in a Patient With Transverse Sinus Thrombosis: A Rare Association.

The primary antiphospholipid syndrome and protein S deficiency are known hypercoagulable states predisposing to strokes. We present a 34-year-old woman presented to rheumatology clinic complaining of right side weakness and aphasia for 2 months before the visit. There was joint pain in the right elbow and shoulder joints, hyperpigmentation on her face and dry painful red eyes mainly the right eye in addition to dry mouth.

Design, synthesis and anti-proliferative evaluation of new pyridine-2,3-dihydrothiazole/thiazolidin-4-one hybrids as dual CDK2/GSK3β kinase inhibitors.

Herein, the molecular hybridization drug discovery approach was used in the design and synthesis of twelve novel pyridine-2,3-dihydrothiazole hybrids (2a,b-5a,b and 13a,b-14a,b) and fourteen pyridine-thiazolidin-4-one hybrids (6a,b-12a,b) as anti-proliferative analogues targeting CDK2 and GSK3β kinase inhibition. Almost all of the newly synthesized hybrids, including their precursors (1a,b), were evaluated for their anti-proliferative activity against three human cancer cell lines-MCF-7, HepG2 and HEp-2-as well as normal Vero cell lines. Both compounds 1a (pyridine-thiourea precursor) and 8a (pyridine-5-acetyl-thiazolidin-4-one hybrid) exhibited excellent anti-proliferative activity against HEp-2 (IC = 7.

Design, synthesis, biological evaluation, and docking studies of novel triazolo[4,3-]pyridazine derivatives as dual c-Met/Pim-1 potential inhibitors with antitumor activity.

Interest has been piqued in c-Met and Pim-1, potential new cancer treatment targets. A variety of triazolo[4,3-]pyridazine derivatives were synthesized to create powerful dual c-Met/Pim-1 inhibitors having the pharmacophoric elements of both enzyme inhibitors. All derivatives were screened for their cytotoxic effects on 60 cancer cell lines.

Benzenesulfonohydrazide-tethered non-fused and fused heterocycles as potential anti-mycobacterial agents targeting enoyl acyl carrier protein reductase (InhA) with antibiofilm activity.

Because resistant variants of the disease are always emerging, tuberculosis is a global issue that affects economies. New antitubercular medications should be developed, and this can be done by inhibiting druggable targets. Enoyl acyl carrier protein (ACP) reductase (InhA) is a crucial enzyme for the survival of (MTB).

Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.

Microtubules are highly dynamic structures and constitute a crucial component of the cellular cytoskeleton. Besides, topoisomerases (Topo) play a fundamental role in maintaining the appropriate structure and organization of DNA. On the other hand, dual mechanism drug candidates for cancer treatment primarily aim to enhance the efficacy of cancer treatment and potentially overcome drug resistance.

Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management modulation of the cGAS-STING pathway.

NAFLD/NASH has emerged as a global health concern with no FDA-approved treatment, necessitating the exploration of novel therapeutic elements for NASH. Probiotics are known as an important adjunct therapy in NASH. Zbiotics (ZB183) is the first commercially available genetically engineered probiotic.

Prevalence of iron overload in patients with chronic kidney disease on peritoneal dialysis: A scoping review.

Background And Aims: Chronic kidney disease (CKD) patients undergoing peritoneal dialysis (PD) are susceptible to complications, including iron overload, which can significantly impact their prognosis and overall health. This scoping review aimed to study the prevalence and implications of iron overload in CKD patients undergoing PD.

Methods: A comprehensive search was conducted across five databases, leading to the selection of 18 papers for in-depth analysis.

Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation.

Cancer patients undergoing chemotherapy are highly susceptible to infections owing to their compromised immune system, which also promotes cancer progression through inflammation. Thus, this study aimed to develop novel chemotherapeutic agents with both anticancer and antimicrobial properties. A series of diarylurea derivatives based on pyridazinone scaffolds were designed, synthesized, and characterized as surrogates for sorafenib.

Synthesis of novel piperazine-based bis(thiazole)(1,3,4-thiadiazole) hybrids as anti-cancer agents through caspase-dependent apoptosis.

A series of novel piperazine-based bis(thiazoles) 13a-d were synthesized in moderate to good yields reaction of the bis(thiosemicarbazones) 7a, b with an assortment of -acetyl--aryl-hydrazonoyl chlorides 8a-f. Similar treatment of the bis(thiosemicarbazone) 7a, b with -aryl--phenylhydrazonoyl chlorides 10a, b afforded the expected bis(thiadiazole) based piperazine products 13b-d in reasonable yields. Cyclization of 7a, b with two equivalents of α-haloketones 14a-d led to the production of the corresponding bis(4-arylthiazol)piperazine derivatives 15a-h in good yields.

Sculpting the future: A narrative review of 3D printing in plastic surgery and prosthetic devices.

Background And Aims: The advent of 3D printing has revolutionized plastic surgery and prosthetic devices, providing personalized solutions for patients with traumatic injuries, deformities, and appearance-related conditions. This review offers a comprehensive overview of 3D printing's applications, advantages, limitations, and future prospects in these fields.

Methods: A literature search was conducted in PubMed, Google Scholar, and Scopus for studies on 3D printing in plastic surgery.