Novel dual responsive embelin functionalised ZnO nanomaterials amplify DNA damage and induce apoptosis via pERK1/2/p53 pathway in pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis and chemoresistance. Nano-bioconjugates, due to their enhanced surface-to-volume ratio, offer significant potential in cancer therapy. In this study, we synthesized ZnO nanoparticles (NPs) using solution combustion method and exhibited a particle size range of 20-70 nm as confirmed by TEM analysis.

Deciphering Gut Microbiome Dynamics in Irritable Bowel Syndrome Using Deep Learning.

Purpose: This work delves into the critical role of the human gut microbiome in health and disease, emphasizing its influence on a range of physiological processes and its connection to conditions such as irritable bowel syndrome (IBS). The microbiome is made up of a very large and complicated group of microorganisms that have big effects on metabolic and immune functions. This makes it an interesting area for researching new ways to diagnose and treat diseases.

Automated labeling in medical data: A semi-supervised density-based approach for efficient diagnosis model development.

Background: In the rapidly expanding landscape of medical data acquisition, the demand for automated diagnosis and analysis models is paramount to support healthcare practitioners. Providing a learning model for automatic diagnosis and analysis is a necessity to support them. To formulate a diagnosis model, labeling the entire data manually is necessary.

Phytotoxicity Mitigation and Malachite Green Removal from Wastewater Using Superparamagnetic Activated Carbon.

This study addresses the removal of malachite green (MG) dye from water utilizing magnetic activated carbon prepared from flowers of (SCMAC). The prepared SCMAC displayed an exceptional specific surface area (1012.9 m/g) with mesopores (2.

Design, synthesis, crystal structure of novel hydrazone analogues as SARS-CoV-2 potent inhibitors: MD simulations, MM-GBSA, docking and ADMET studies.

In this study, we have synthesized novel thiohydrazone and hydrazone analogues by one-pot methodology with good to excellent yields (85%-91%). molecular dynamics (MD) simulations, docking, and absorption, distribution, metabolism, excretion and toxicity (ADMET) were evaluated as inhibitor activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PDB ID: 5N5O) main protease. The dynamics simulations studies and docking were conducted by GROMACS and AutoDock Vina.

Optimization of growth conditions on silicone elastomer material by response surface methodology.

Biofilm in the emerging pathogen and the most prevalent Non- infections is linked to fouling of medical devices and virulence. The growth conditions (temperature, media pH, incubation time, inoculum size, and shaker speed) for clinical cultures of were optimized on silicone elastomer material by Central composite design based on Response surface methodology. Six clinical cultures (C4, U873, U951, U1179, U1309 and U1360) and a standard culture (MTCC-184) were chosen for the study.

Peltophorum pterocarpum flower mediated synthesis of silver nanoparticles and its catalytic degradation of Acid Blue 113 dye.

In this study, silver nanoparticles (AgNPs) were synthesized using a green method involving Peltophorum pterocarpum flower extract. Successful formation of AgNPs was confirmed by a characteristic surface plasmon resonance peak at 416 nm in the UV-Vis spectrum. SEM and TEM analyses revealed uniformly spheroidal nanoparticles with an average size of 25.

Adsorptive removal of fluoride from water using hydroxyapatite synthesized from marine shell waste.

Fluoride contamination in groundwater threatens human health and ecological systems, necessitating cost-effective and efficient remediation strategies. This study synthesized hydroxyapatite (MRS-HAp) from Marcia recens shells through chemical precipitation to serve as a potential adsorbent for the removal of fluoride. The prepared MRS-HAp exhibited a specific surface area of 100.

Synthesis and characterization of Zn and Fe doped magnetic biochar from Acacia falcata leaves for Cr(VI) adsorption.

Hexavalent chromium (Cr(VI)), a toxic pollutant extensively utilized across multiple industries, necessitates effective treatment using low-cost and sustainable materials. In this research, magnetic biochar (MBC) was prepared using Acacia falcata leaves through chemical treatment with ZnCl and incorporating FeO nanoparticles using FeCl·6HO as a precursor. BET analysis revealed a specific surface area of 248.

Computational analysis of promoter features associated with contrasting expression patterns of human genes under normal and disease conditions.

The promoter region plays a critical role in regulating gene expression, particularly in complex vertebrate genomes. However, promoters associated with contrasting gene expression patterns have not been comprehensively characterized. In this study, we systematically analyzed multiple features of human promoter sets corresponding to contrastingly expressed gene sets or transcripts (PCeGs).

Spectroscopic and Computational Analysis of 5PPD-CeO: Insights from Fluorescence Quenching and FRET Studies.

This investigation explores the impact of synthesized cerium oxide nanoparticles (CeO NPs) on the solvatochromic behaviour and fluorescence resonance energy transfer (FRET) of the compound 5-phenyl-1-pyridine-3-yl-penta-2,4-dien-1-one in various solvents. The dipole moments of this compound have been estimated using theoretical and experimental methods. Furthermore, the analysis of CeO NPs concentration on the organic fluorophore was conducted using the Benesi-Hildebrand equation, the findings indicated a substantial transfer of energy between CeO NPs and 5PPD.

Sustainable activated carbon from copper pod tree leaves for efficient tetracycline removal and regeneration.

The persistence of tetracycline (TC) in water poses environmental risks, including antibiotic resistance, necessitating effective removal. This study explores the synthesis and application of activated carbon from copper pod tree leaves for TC adsorption. The adsorbent was produced through orthophosphoric acid activation at low temperature and characterized using multiple techniques.

Mesoporous activated carbon from Tabebuia aurea leaves for effective adsorptive removal of 2,4-dichlorophenoxyacetic acid.

The extensive use of herbicides in agriculture contributes to water pollution, posing a significant environmental risk. This study focused on the HPO activation of Tabebuia aurea leaves to prepare activated carbon. The resulting adsorbent was then tested for its capability to eliminate 2,4-dichlorophenoxyacetic acid (2,4-D), the heinous herbicide.

A critical review of geriatric care in India with regard to the needs, challenges and opportunities: a wearable care approach.

Home is more than just a word; it represents a profound emotion for every individual. Hospitalization often deprives the geriatric population of this comforting environment due to their deteriorating health. However, with technology-oriented automated and monitored assistance systems, older adults can receive adequate care and support at home, allowing them to lead independent lives.

Assessment of the level of uranium in groundwater and the role of public water purifiers in mitigating the concentration- A study from the south-western part of Bengaluru, Karnataka, India.

Groundwater samples were gathered from various sites adjacent to Manchanabele Reservoir and their uranium concentration was measured using a Light Emitting Diode (LED) fluorimeter. The results show that the uranium concentration varied widely from 0.2 to 358.

Mesoporous hydrochar from Acacia falcata leaves by hydrothermal process for hexavalent chromium adsorption.

This study evaluates mesoporous-hydrochar derived from Acacia falcata leaves via a single-step hydrothermal treatment for Cr(VI) adsorption. Material characterization indicated that the adsorbent has a rough and porous structure. FTIR analysis confirmed Cr(VI) adsorption through functional group interactions, evidenced by peak intensity changes and the emergence of a Cr-O bond vibration at 669 cm.

Optimizing achalasia diagnosis in the era of high-resolution manometry: A Pakistani perspective.

Background: High-resolution manometry (HRM) is a gold standard for diagnosing achalasia and identification of its subtypes, but data regarding its correlation with clinical, endoscopic, and radiological features in low-resource settings like Pakistan are limited. This study aims to identify and compare manometric parameters with other diagnostic parameters among achalasia subtypes in Pakistani population.

Methodology: A retrospective analysis of clinical, endoscopic, and radiological features of 381 patients who underwent HRM at Center for Liver and Digestive Diseases, Holy Family Hospital, Rawalpindi, Pakistan, from December 2015 to February 2024 was performed.

Dengue Virus Life Cycle and Host Protein Interactions: Focus on RNA Binding Proteins and Therapeutic Advances.

Dengue, a widespread arthropod-borne viral disease, remains endemic in more than 100 nations, affecting over 40% of the world's population, with millions of cases reported annually, and has a major burden on global public health systems. The causative agent of this infection is the dengue virus which belongs to the Flaviviridae family of RNA viruses. The DENV infection leads to a broad spectrum of clinical symptoms, ranging from mild to severe, and even fatal in the cases of secondary infection.

Antimicrobial hybrid coatings: A review on applications of nano ZnO based materials for biomedical applications.

The extreme survivability of infectious microorganisms on various surfaces prompts for the risk of disease transmissions, posing a perilous concern for global health. Thus, the treatment of these pathogenic microorganisms using the nanomaterials functionalized with antimicrobial coatings reaps relevant scope in the ongoing trend of research. Driven by their admirable biocompatibility, cost-effectiveness, and minimal toxicity, ZnO nanoparticles (ZnO-NPs) based antimicrobial hybrid coatings have emerged as a robust material to prevent the growth of infectious microorganisms on various surfaces, which in turn boosted their applications in the area of biomedical sciences.

Designing a multi-epitope vaccine candidate against pandemic influenza a virus: an immunoinformatics and structural vaccinology approach.

Influenza A virus (IAV) remains a significant public health concern due to its annual epidemics and potential for global pandemics. Despite the availability of countermeasures such as vaccines and antiviral treatments, their effectiveness is often questioned due to the emergence of novel strains with antiviral resistance and the variable efficacy of influenza vaccines compared to other vaccines. Traditionally, influenza vaccination strategies have focused on matrix, neuraminidase, and nucleoproteins.

Development and Characterization of Potato Starch-Pectin-Based Active Films Enriched With Juniper Berry Essential Oil for Food Packaging Applications.

The increasing demand for sustainable food packaging has driven the development of films based on biopolymers. However, enhancing their functional properties remains a challenge. In the current study, potato starch-pectin (PSP) composite films were fabricated and enriched with juniper berry essential oil (JBEO) to improve their physicochemical properties.

In Situ Aqueous Spice Extract-Based Antifungal Lock Strategy for Salvage of Foley's Catheter Biofouled with Biofilm Gel.

forms a gel-like biofilm in the Foley's catheter (FC) causing tenacious biofouling and severe urinary tract infections (UTIs). For the first time, a spice extract-based antifungal lock therapy (ALT) has been developed to inhibit the gel matrix in FC. Aqueous extracts of garlic, clove, and Indian gooseberry were used as ALT lock solutions and tested against biofilm-forming multidrug-resistant clinical isolates of .

Optimizing Linezolid: Transforming It into a Selective MAO-B Inhibitor via a Toxicity-to-Activity Optimization Approach.

Linezolid, a widely used oxazolidinone antibiotic, exhibits potent activity against resistant bacterial infections but is associated with serotonergic toxicity, primarily due to its inhibition of monoamine oxidase (MAO). MAOs, consisting of MAO-A and MAO-B isoforms, play crucial roles in neurotransmitter metabolism, with implications for neurodegenerative disorders like Parkinson's and Alzheimer's diseases. This study aims to optimize Linezolid's structure to transform it into a selective MAO-B inhibitor.

Efficient adsorptive removal of Congo Red dye using activated carbon derived from Spathodea campanulata flowers.

This report investigates the preparation, characterization, and application of activated carbon derived from Spathodea campanulata flowers (SCAC) to remove Congo Red (CR) dye from aqueous streams. SCAC was synthesized using orthophosphoric acid activation which yielded a mesoporous material with a specific surface area of (986.41 m/g), significantly exceeding values reported for flower-derived activated carbons in the available literature.