Oncological Outcomes of Non-clear Cell Renal Cell Carcinomas: A Retrospective Study From a Tertiary Care Center.

Background Non-clear cell renal cell carcinomas (nccRCCs) are a histologically heterogeneous and clinically underrepresented group of renal malignancies, distinct from clear cell RCC in morphology, molecular profile, and prognosis. Despite accounting for 20-30% of RCCs, nccRCC subtypes are infrequently studied, especially in the Indian population. This study aimed to evaluate the clinicopathological features, immunohistochemical patterns, and oncological outcomes of primary nccRCCs in a tertiary care setting.

Physiologically-based pharmacokinetic model for CAR-T cells delivery and efficacy in solid tumors.

Abnormal blood vessels limit the delivery and function of endogenous T cells as well as adoptively transferred Chimeric Antigen Receptor (CAR)-T cells in the tumor microenvironment (TME). We recently showed that vascular normalization using anti-VEGF therapy can overcome these challenges and improve the outcome of CAR-T therapy in glioblastoma models in mice. Here, we developed a physiologically based pharmacokinetic model to simulate the dynamics of both adoptively transferred CAR-T cells and endogenous immune cells in solid tumors following vascular normalization.

Reducing pain and opioid use: Implementation of an enhanced recovery pathway for percutaneous nephrolithotomy with an erector spinae plane block.

Background: There is no standard analgesic pathway after percutaneous nephrolithotomy. At our institution, an Enhanced Recovery After Surgery (ERAS) pathway was instated that included a preoperative erector spinae plane (ESP) block to improve pain control and minimize opioid usage in the postoperative setting.

Materials And Methods: At our institution, an ERAS pathway was created for patients undergoing percutaneous nephrolithotomy.

Pathogenic variation underlying rare diseases in an Arab population: Implications for screening programs.

Purpose: Genetic variation underlying rare diseases in Arab populations is poorly understood limiting effective carrier screening for recessive disorders, which are prevalent because of high consanguineous rates.

Methods: Using the American College of Medical Genetics and Genomics/Association for Molecular Pathology guidelines, we curated pathogenic (P) and likely pathogenic (LP) variants in 1333 Arab Emirati families (346 internal cohort and 987 from the literature). We also analyzed P/LP variants in 1194 Emirati exomes, calculated allele frequencies, and estimated carrier rates for the associated recessive conditions.

Cortisol/DHEA-S Ratio Normalization by Buprenorphine: Associations with Stress, Coping, and Social Support in Youth with Opioid Use Disorder.

Opioid use disrupts the hypothalamic-pituitary-adrenal (HPA) axis, altering stress responses depending on the stage of use. A higher cortisol/DHEA-S ratio may indicate relapse risk in substance use disorders. This study aimed to explore differences in serum cortisol/DHEA-S ratio and its association with proximal and perceived stress, social support, and coping strategies in opioid-dependent youth.