Role of extensification strategies in chicken meat quality.

The latest studies suggest a beneficial influence of husbandry factors, including increased space allowance, access to perches, and roughage, on the welfare of chickens; however, their effects on meat quality are divergent. Two experiments (EXP1 and EXP2) were performed to determine the husbandry factors affecting the meat quality of 42-day-old Ross 308 chickens (n = 180). The examined factors in EXP1 were stocking density (35 kg/m2 vs 41 kg/m2) and enrichment (access to perches), whereas in EXP2, enrichment (perches) and access to roughage (dried lucerne) were examined.

Clinical characteristics and risk factors of metabolic dysfunction-associated steatotic liver disease in lean patients: results of the Polish Gallstone Surgery Registry.

Aim Of The Study: Data concerning the clinical manifestation and outcomes of lean metabolic dysfunction-associated steatotic liver disease (MASLD) are scarce and inconsistent. The aim of the study was to evaluate the clinical characteristics of MASLD and predictors of its occurrence.

Material And Methods: The study included patients from the Polish Gallstone Surgery Registry diagnosed with MASLD according to the current criteria.

Targeting the Opioid System in Cardiovascular Disease: Liver Proteomic and Lipid Profile Effects of Naloxone in Atherosclerosis.

The endogenous opioid system plays a pivotal role in numerous physiological processes and is implicated in a range of diseases, including atherosclerosis, a condition contributing to nearly 50% of deaths in Western societies. This study investigates the effects of opioid receptor blockade, using naloxone, on the plasma lipid profile and atherosclerosis progression. ApoE mice with advanced atherosclerosis were treated with naloxone for seven days, and the effects on atherosclerotic plaque development and liver steatosis were evaluated.

Nfe2l1 dysfunction alters Parkinson's disease-related gene expression and impairs neuronal differentiation under ubiquitin stress in neuronal differentiated P19 Cells.

Proteostasis is essential for neuronal health, and its disruption is implicated in neurodegenerative diseases such as Parkinson's disease (PD). Nfe2l1, a key regulator of proteostasis and ubiquitination, plays a significant role in neuronal health, yet its molecular functions in neuronal cells remain unclear. Our study investigates the role of Nfe2l1 in RA-induced neuronal differentiation of P19 cells under proteasome inhibition.

Phenotypic and Genotypic Evaluation of the Bitter Taste Receptor T2R38 in Chronic Rhinosinusitis.

<b>Introduction:</b> Chronic rhinosinusitis (CRS) is a multifactorial disease in which genetic predisposition plays a significant role. The bitter taste receptor T2R38, expressed in nasal and sinus mucosa, supports innate immunity. Single nucleotide polymorphisms (SNPs) in the <i>TAS2R38</i> gene affect individuals' ability to perceive its agonist - phenylthiocarbamide (PTC) - as bitter.

Combining Topical Oxygen and Negative-Pressure Wound Therapy: New Insights from a Pilot Study on Chronic Wound Treatment.

Chronic wounds are a growing clinical challenge due to their prolonged healing time and associated healthcare burden. Combined therapeutic approaches, including topical oxygen therapy (TOT) and negative-pressure wound therapy (NPWT), have shown promise in enhancing wound healing. This pilot exploratory study aimed to assess the clinical effectiveness of combined TOT and NPWT in chronic wound treatment and to explore the prognostic value of selected laboratory and thermographic markers.

The hepatic and developmental toxicity of chronic morphine and disulfiram co-treatment for pain relief - a comprehensive in vitro and in vivo assessment.

Tolerance and opioid-induced hyperalgesia are clinically relevant side effects that may hinder prolonged opioid use. Recent studies report that disulfiram - a drug registered for alcohol use disorder, fully suppresses their onset. Unfortunately, morphine exacerbating the risk of disulfiram-induced acute liver injury has recently been reported.

Protamine sequence determines species-specific nuclear shape and histone retention.

The nuclear shape observed after the forced expression of mouse or human protamine 1 (PRM1) in fibroblasts led us to propose the hypothesis that the PRM1 sequence plays an important role in imposing the overall shape of the protaminized nucleus. Comparison of mouse and human PRM1 sequences pointed to cysteines 15 and 29 as potential critical residues in the mouse PRM1 sequence, inducing the characteristic mouse "hooked" nuclear sperm shape. To explore this idea, mice with mutations in PRM1 Cys15 and Cys29 were generated.

Synergistic potential of CDK4/6 inhibitors and ATRA in non-APL AML.

Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by diverse genetic abnormalities. The standard of care remains to be chemotherapy and stem cell transplantation. In acute promyelocytic leukaemia (APL), differentiation therapy with all-trans retinoic acid (ATRA) has significantly improved outcomes.

A 360° perspective on cardiovascular prevention: the International Lipid Expert Panel SiMple tIps for the heaLthy hEart (ILEP-SMILE).

Cardiovascular disease (CVD), particularly atherosclerotic cardiovascular disease (ASCVD), is the most common cause of death worldwide. Despite decades of research into lifestyle factors and medications, we still cannot effectively prevent the occurrence of ASCVD or the many incident CVD events and their complications. Yet, in most countries, only a small percentage of the healthcare budget is allocated to (primary) prevention, and only a few nations have introduced effective integrated (coordinated) programmes in primary prevention to promote health education, invest in health as early as possible, and prevent adverse CVD events.

The Gene Expression Profile of Milk Somatic Cells of Small Ruminant Lentivirus-Seropositive and -Seronegative Dairy Goats () During Their First Lactation.

Unlabelled: Caprine arthritis and encephalitis (CAE), caused by small ruminant lentivirus (SRLV), is a key disease of goats, with chronic inflammation of joints and brain symptoms leading to losses in milk production and animal trade. In this study, we analyzed gene expressions in the milk somatic cells (MSCs) of seropositive (SRLV-SP) and seronegative (SRLV-SN) goats to identify transcriptomic changes using a non-invasive sampling method.

Materials And Methods: This study was conducted on goats of two Polish breeds (Polish Improved White and Polish Improved Fawn), which were kept at the Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, during their first lactation.

Unlocking the African bioeconomy and strengthening biodiversity conservation through genomics and bioinformatics.

The African BioGenome Project (AfricaBP) is a Pan-African initiative aimed at improving food systems and biodiversity conservation through genomics while ensuring equitable data sharing and benefits. The Open Institute is the knowledge exchange platform of the AfricaBP, which aims to bridge local knowledge gaps in biodiversity genomics and bioinformatics and enable infrastructural developments. In 2024, the AfricaBP Open Institute advanced this mission by organizing 31 workshops that attracted more than 3500 registered attendees across 50 African countries, provided training to 401 African researchers in genomics, bioinformatics, molecular biology, sample collections and biobanking, and ethical considerations, across all five African geographical regions involving 40 African and non-African organizations.

Platelets in Hepatocellular Carcinoma-From Pathogenesis to Targeted Therapy.

Hepatocellular carcinoma (HCC) is a malignancy with a complex pathogenesis, course, and prognosis with increasing incidence. The most significant contributing factor to the development of HCC is the chronic process of inflammation and remodeling of the cirrhotic liver, in which the interaction between the tumor microenvironment (TME) and cancer cells plays a pivotal role. In recent years, increasing focus has been directed toward the role of platelets (PLTs) in mediating interactions between tumor cells and the TME and in the progression and spread of HCC, as well as other cancers.

Nrf1 acts as a highly-conserved determinon for maintaining robust redox homeostasis in the eco-evo-devo process of life histories.

Differential and even opposing functions of two major antioxidant transcription factors Nrf1 and Nrf2 (encoded by and , respectively) are determined by distinctions in their tempospatial positioning, topological repartitioning, proteolytic processing, and biochemical modification, as well as in their shared evolutionary origin. As a matter of fact, the allelopathic potentials of Nrf1 and Nrf2 (both resembling two entangled 'Yin-Yang' quanta that comply with a dialectic law of the unity of opposites) are fulfilled to coordinately control redox physiological homeostasis so as to be maintained within the presetting thresholds. By putative exponential curves of redox stress and intrinsic anti-redox capability, there is inferable to exist a set point at approaching zero with the 'Golden Mean' for the healthy survival (i.

Exploring the role of catalytic triad Ser-His-Asp on the dynamics of the Lactobacillus helveticus cell-envelope proteinases.

Lactic acid bacterium (LAB) hydrolyzes milk proteins into small bioactive peptides to flourish milk nutrition value. Cell-envelope proteinases (CEPs) are vitally important to bacterial growth, the texture and flavor formation, and the generation of bioactive peptides in fermented milk. Previous literature suggested PR domain of CEP was responsible for the catalytic activity.

The Struggle Between Chimeric Antigen Receptor T-Cell Therapy and Neurological Complications in Acute Lymphoblastic Leukemia Treatment.

Acute lymphoblastic leukemia (ALL) accounts for approximately 25% of childhood cancers and 20% of leukemia cases in adults, with a higher prevalence in males than females. It is characterized by symptoms such as fatigue, fever, and bone pain and poses a significant risk of mortality if left untreated. While chemotherapy and stem cell transplantation are standard treatments, their efficacy declines in relapsed or refractory cases, highlighting the need for innovative therapeutic approaches.

Stage-sensitive potential of isolated rabbit ICM to differentiate into extraembryonic lineages†.

In the course of mammalian development, the initial state of totipotency must be lost to allow the acquisition of specific cell fates. The first differentiation event results in the formation of trophectoderm (TE) and the inner cell mass (ICM). In the mouse embryo, the cell fate of these two compartments is set quickly after blastocyst formation.

Exploring #HealthLiteracy on LinkedIn: a first look at health hashtag engagement in a professional social media context.

LinkedIn, despite its large and professionally credentialed user base, remains an underexplored platform for digital health communication, unlike X (formerly Twitter), which has been widely studied for health-related hashtag trends. Health literacy, a key determinant of public health, is increasingly promoted through social media hashtags such as #HealthLiteracy. However, to date, no studies have systematically examined how this hashtag is used on LinkedIn.

Characterising nosing behaviours in pigs after mixing using social network analysis.

Affiliation as indicated by proximity has, to date, been used as the principal measure of positive relationships in farm animals. However, intensive housing may present a caveat to using proximity as a representation of affiliation as animals may be forced into proximity by stocking densities. To investigate affiliation patterns, this study examined differences in the expression of proximity and contact behaviours following regrouping in pigs.

Current Approaches to Aflatoxin B1 Control in Food and Feed Safety: Detection, Inhibition, and Mitigation.

Aflatoxins, toxic secondary metabolites produced primarily by and , pose a significant global health concern due to their frequent presence in crops, food, and feed-especially under climate change conditions. This review addresses the growing threat of aflatoxins by analyzing recent advances in detection and mitigation. A comprehensive literature review was conducted, focusing on bioremediation, physical and chemical detoxification, and fungal growth inhibition strategies.

Oral fluid as a material for serological diagnostics of caseous lymphadenitis in goats.

Corynebacterium pseudotuberculosis causes caseous lymphadenitis (CLA) in goats and sheep. This study assessed oral fluid (OF) as a minimally invasive sample for CLA serodiagnosis by detecting antibodies to phospholipase D (PLD), CP40 protein, and protein kinase G (PknG) using Western blot (WB). Serum and OF samples from 96 goats from a CLA-affected herd in Poland were tested using a commercial ELISA coated with recombinant PLD (rPLD-ELISA; serum only) and WB (serum and OF).

#NeuroTwitter: A Hashtag Analysis Study of Global Neurology Conversations on X.

Introduction Studies show that X (formerly Twitter) significantly amplifies healthcare content online. This platform is valuable for monitoring public health trends and global healthcare patterns. Within neurology, it would be advantageous to explore the dissemination of information related to neurological matters by using #NeuroTwitter.

Exploring the Role of Polymorphisms in Colorectal Cancer Risk: A Case-Control Study.

Colorectal cancer (CRC), the most common malignancy of the gastrointestinal tract, is the second leading cause of cancer-related deaths worldwide. In this context, investigating low-penetrance gene variants associated with the increased risk of CRC represents a novel and crucial approach to enhancing prevention strategies and clinical surveillance. By focusing on these genetic variants, there is potential for more accurate prediction of individual CRC risk, which could contribute to the refinement of current screening and prophylactic programs.

Ginger () dietary supplementation in mice regulates liver antioxidant defense systems in a dose- and age-dependent.

Introduction: Oxidative stress and impaired antioxidant defenses contribute significantly to liver dysfunction, particularly with aging. This study evaluated the dose- and age-dependent effects of dietary ginger () supplementation on liver antioxidant defense systems in mice.

Methods: Male Swiss Webster mice aged 3, 6, and 12 months (n = 48 per age group) received standard feed or feed supplemented with either 0.

Cell-context response to germ layer differentiation signals is predetermined by the epigenome in regionalized epiblast populations.

Stem cells hold promise in regenerative medicine as they have the potential to differentiate into a variety of specialized cell types. However, mechanisms underlying stem cell potency and lineage acquisition remain elusive. Epigenetic modifications and genome accessibility prime cellular feedback to signalling cues, influencing lineage differentiation outcomes.