Unilateral thalamotomy with high-intensity focused ultrasound in refractory tremor. First results of a public hospital in Spain.

Introduction: Unilateral high-intensity focused ultrasound (HIFU) thalamotomy is a novel and efficient treatment for refractory tremor. In the most recent studies, the tremor is reduced by at least 70%. The objective of this study is to analyse the results of the first series of cases treated in a public hospital in Spain.

Spanish cardiac catheterization and coronary intervention registry. 34 official report of the Interventional Cardiology Association of the Spanish Society of Cardiology (1990-2024).

Introduction And Objectives: This report presents the 2024 activity data from the Interventional Cardiology Association of the Spanish Society of Cardiology (ACI-SEC).

Methods: All interventional cardiology laboratories in Spain were invited to complete an online survey. Data analysis was conducted by an external company and then reviewed and presented by the ACI-SEC board.

Identification of a novel transcriptome signature for predicting the response to anti-TNF-α treatment in patients with rheumatoid arthritis.

Objectives: This study aims to identify and validate a transcriptomic signature capable of predicting the response to tumour necrosis factor inhibitors (TNFi) therapy in patients with rheumatoid arthritis (RA) before treatment initiation.

Methods: We performed a retrospective transcriptomic analysis using 2 public datasets, RNA-seq data from peripheral blood mononuclear cells (GSE138746) and microarray data from whole blood (GSE33377), to define a small-scale gene signature predictive of the response to TNFi treatment. Three external validations were then conducted, resulting in a total of 279 individuals, 169 responders, and 110 nonresponders.

Orthodontic Treatment in Patients With Epidermolysis Bullosa (EB)-Clinical Practice Guidelines (CPG).

Background: Epidermolysis bullosa (EB) is a rare genetic condition characterized by skin and mucosal fragility. The clinical phenotype is highly variable. Severe types and subtypes, such as junctional EB (JEB), kindler EB (KEB), and recessive dystrophic EB (RDEB), are considered to present a high risk of oral health problems, including malocclusions.

DICER1-Related Pediatric Thyroid Neoplasm with Follicular and Morular Growth: A Tumor that Did Not Read the Textbook.

Thyroid lesions associated with DICER1 syndrome include multifocal hyperplastic and benign neoplastic proliferations (follicular nodular disease) with characteristic macrofollicular and/or intrafollicular centripetal papillary growth patterns, frequently associated with atrophic and involutional changes. There are also well-differentiated thyroid carcinomas showing intermediate-type nuclei, sometimes combining high-grade areas (tumor-in-tumor pattern) and poorly differentiated carcinomas. Here, for the first time, we describe an encapsulated follicular cell thyroid tumor showing a mixed follicular and morular growth pattern, which presented in an 11-year-old girl with follicular nodular disease and a constitutional (germline) DICER1 p.

Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction.

Background: Current guideline recommendations for the use of beta-blockers after myocardial infarction without reduced ejection fraction are based on trials conducted before routine reperfusion, invasive care, complete revascularization, and contemporary pharmacologic therapies became standard practice.

Methods: We conducted an open-label, randomized trial in Spain and Italy to evaluate the effect of beta-blocker therapy, as compared with no beta-blocker therapy, in patients with acute myocardial infarction (with or without ST-segment elevation) and a left ventricular ejection fraction above 40%. The primary outcome was a composite of death from any cause, reinfarction, or hospitalization for heart failure.

High-Dose Influenza Vaccine to Reduce Hospitalizations.

Background: Superior protection against laboratory-confirmed influenza has been proved for high-dose inactivated influenza vaccine, as compared with the standard dose, among adults 65 years of age or older. However, data on the relative effectiveness of the high-dose vaccine against severe clinical outcomes, including hospitalizations, are limited.

Methods: We conducted a pragmatic, registry-based, open-label, randomized, active-controlled trial to evaluate the relative effectiveness of high-dose inactivated influenza vaccine, as compared with the standard dose, against severe clinical outcomes among community-dwelling adults 65 to 79 years of age.

Retinoic Acid Profiles in Proliferative Verrucous Versus Homogeneous Leukoplakia: A Preliminary Nested Case-Control Study.

: Oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL) remain challenging entities due to the absence of reliable prognostic biomarkers. All-trans retinoic acid (atRA), a pivotal modulator of epithelial differentiation and mucosal integrity, has been proposed as a candidate biomarker. This study sought to quantify plasma RA levels in patients with OL and PVL compared to healthy controls, assessing their potential clinical utility.

Arrhythmic genotypes in dilated cardiomyopathy and risk of advanced heart failure.

Background And Aims: Certain genetic forms of dilated cardiomyopathy (DCM) entail a higher arrhythmic risk. It is unknown whether DCM patients with high-risk arrhythmic genotypes also develop more advanced heart failure (AHF) complications. AHF events were studied according to DCM genotype.

Evaluation of carbohydrate antigen 125 in heart failure with preserved ejection fraction diagnosis.

Background: Current evidence supports the role of circulating carbohydrate antigen 125 (CA125) in risk assessment, disease monitoring and therapeutic guidance in heart failure (HF). However, there is limited data on its diagnostic applicability. This study aimed to assess the diagnostic performance of CA125 in identifying HF with preserved ejection fraction (HFpEF) in an outpatient population.

Industry payments to US neurologists related to multiple sclerosis drugs and prescribing (2015-2019): a retrospective cohort study.

Objectives: To measure the prevalence and magnitude of industry payments to neurologists prescribing multiple sclerosis (MS) drugs and determine whether payments are associated with prescribing.

Design: Retrospective observational study.

Setting: Data on neurologists prescribing MS drugs from 2015 to 2019 in the Medicare Part D database linked to the Centers for Medicare & Medicaid Services Open Payments database.

Predicting Stroke Etiology with Radiomics: A Retrospective Study.

: The composition of the thrombus is not taken into account in the etiology determination of patients with acute ischemic stroke (AIS); however, it varies depending on the origin of the thrombus, as atherothrombotic thrombi contain more red blood cells and cardioembolic thrombi contain more fibrin and platelets. Radiomics has the potential to provide quantitative imaging data that may vary depending on the composition of thrombi. The aim of this study is to predict cardioembolic and atherothrombotic thrombi using radiomic features (RFs) from non-contrast computed tomography (NCCT) brain scans.

Impact of the environment on health status of intensive care unit patients: Functional data analysis using wearable monitoring systems.

Objectives: Environmental factors in critical care units (ICUs) can significantly impact patient health. Traditional analysis methods often struggle with the continuous temporal data from wearable monitoring devices. This study explores the novel application of functional data analysis (FDA), a methodology well suited for continuous signals, to assess how environmental exposures influence ICU patient outcomes over time.

Impact of fine particulate matter (PM) pollution on hospital admissions and mortality due to acute myocardial infarction in Spain.

Introduction And Objectives: Atherosclerotic vascular disease is the main cause of mortality attributable to air pollution. This study analyzes, for the first time, the association between levels of fine particulate matter (PM, particles ≤ 2.5μm in diameter) and hospital admissions and in-hospital mortality due to acute myocardial infarction (AMI) in hospitals of the Spanish National Health System.

Digital biomarkers and artificial intelligence: a new frontier in personalized management of inflammatory bowel disease.

Background And Aims: Artificial intelligence (AI) is rapidly gaining traction in gastroenterology, particularly in the management of inflammatory bowel disease (IBD). Given the complexity of IBD care, AI offers the potential to enhance diagnosis, monitoring, and treatment. This review aims to summarize recent developments in AI applications for IBD and identify key challenges and opportunities for future research and clinical implementation.

Integrative taxonomy suggests hidden diversity within the fish genus Cyttopsis (Zeiformes, Parazenidae).

Nine specimens of Cyttopsis rosea (Zeiformes: Parazenidae) were collected during scientific surveys at three different locations in the northeast Atlantic. All nine specimens were included in the molecular analysis, adding new cytochrome c oxidase subunit I sequences to public databases. Of these, six specimens were retained for detailed morphological examination.

Central hypothyroidism and cardiovascular disease: a Spanish cohort observational study.

Purpose: Little is known about cardiovascular (CV) risk in patients with central hypothyroidism. We aimed to describe the prevalence and incidence of cardiovascular risk factors (CVRFs), cardiovascular diseases (CVDs), and mortality in adults with central hypothyroidism.

Methods And Patients: This multicenter, retrospective, observational study included patients with central hypothyroidism treated at 14 tertiary hospitals in Spain.

Observance of the Atlantic Diet in a Healthy Population from Galicia (NW Spain): A Comparative Study Using a New Scale-Based Procedure to Assess Adherence.

The Atlantic Diet (AD) is based on traditional dietary patterns in Galicia (northwestern Spain) and northern Portugal and is known for its health benefits. The AD focuses on fresh, local, and seasonal foods, especially fish, seafood, vegetables, legumes, whole grains, fruit, olive oil, and a moderate consumption of wine. However, it has received less attention from researchers than other dietary patterns.

Unraveling Epigenetic Alterations Through Genome-Wide DNA Methylation Analysis and Their Implications for Colorectal Cancer.

Aberrant DNA methylation has been shown to be a fingerprint characteristic in human colorectal tumors. In this study, we hypothesize that investigating global DNA methylation could offer potential candidates for clinical application in CRC. The epigenome-wide association analysis was conducted in both the tumor area (N = 27) and the adjacent tumor-free (NAT) area (N = 15).

Cerebellar non-invasive stimulation of social and emotional mentalizing: A meta-analysis.

The present meta-analysis investigated the impact of non-invasive stimulation, using transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) targeting the posterior cerebellum, on social and emotional mentalizing about others. Prior research has convincingly shown that the posterior cerebellum supports social and emotional cognition. We identified 14 studies targeting the cerebellum with appropriate control conditions (i.

Soluble guanylate cyclase stimulation improves cardiac function and mitochondrial activity in a rat model of early-stage heart failure with preserved ejection fraction.

Targeting cardiac mitochondrial dysfunction and cardiac metabolic reprogramming is critical for improving chronic heart failure (HF) treatment. While the soluble guanylate cyclase stimulator vericiguat has shown promise in treating HF with reduced ejection fraction (HFrEF), its effects on HF with preserved ejection fraction (HFpEF), particularly on myocardial bioenergetics, remain undefined. This study aimed to clarify the effects of vericiguat on cardiac function and metabolism in a preclinical model of early-stage HF.

Consensus Document SEPAR-AAMR-ALAT-ASONEUMOCITO-SMNCT on Assessment and Treatment for Consumers of New Tobacco and Nicotine Products.

The use of new tobacco and nicotine products (electronic nicotine delivery system, heated tobacco, and smoking water pipes) has increased in recent years worldwide. This has led to the emergence of a new smoker profile whose diagnostic and therapeutic approach is different from that of conventional tobacco smokers. The demand for help in quitting these new forms of smoking necessitates the development of guidelines or recommendations that are not currently available.

Predictors of progression after surgery in non-functioning pituitary macroadenomas: a Spanish multicenter study.

Background And Purpose: Non-functioning pituitary adenomas (NFPAs) have an unpredictable clinical course, with recurrence and progression posing significant challenges. This study aims to evaluate progression-free survival (PFS) and identify predictors and patterns of tumor progression.

Methods: We conducted a retrospective multicenter study including 472 patients with NFPAs > 1 cm from 17 Spanish hospitals (416 surgical, 56 conservative management).

Age of smartphone access: implications for problematic internet use and online risk behaviors.

Introduction: Access to smartphones raises concerns on multiple levels, particularly because it serves as a gateway to situations of online vulnerability and facilitates the development of risky behaviors, such as problematic internet use (PIU). Therefore, the aim of this study was to analyze whether earlier access of children to a smartphone of their own promotes a differential pattern of internet use, with higher percentages of PIU and online risk behaviors.

Material And Methods: We conducted a cross-sectional study in 31 secondary schools in Galicia (Spain).

Whole genome DNA methylation profiles define Meniere's disease subclusters.

Meniere disease (MD) is a cochleo-vestibular syndrome defined by episodes of vertigo associated with tinnitus and sensorineural hearing loss. While MD immune response has been linked to autoinflammation and type 2 cytokines, other molecular mechanisms such as DNA methylation have an emerging yet underexplored role in MD pathophysiology.To understand the role of DNA methylation in MD, we performed whole-genome bisulphite sequencing in MD patients (n = 40) and controls (n = 13) and used differentially methylated cytosines (DMCs) to define clusters, cell types, and biochemical pathways in MD.