Health literacy and risk factors for preeclampsia: A case-control study in community health centers of Maros district, south Sulawesi.

Background: Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. It is characterized by hypertension and proteinuria occurring after 20 weeks of gestation. This study aims to analyze the role of health literacy, along with sociodemographic and medical factors, as determinants of preeclampsia risk among pregnant women.

Forest Type, Bark Wounding, and Tapping: Their Combined Influence on Bacteria Biota of Styrax Paralleloneurus in Natural and Community Forest.

Styrax paralleloneurus is a resin-producing tree native to Sumatra, Indonesia. This study investigated the effects of tapping, bark wounding and forest type on bacterial biota in the stem of styrax in natural and community forests. Amplicon metagenomic sequencing of the 16S rRNA region was deployed to identify the bacterial communities associated with tapped and untapped trees across various environmental and experimental conditions.

Maternal vitamin D intake correlates with serum 25-Hydroxyvitamin D, Interleukin-6, and ferritin in maternal and umbilical cord.

Background Vitamin D is associated with fetal growth and development. It also plays an essential role in the body's immune system and placental regulation of the mother. This study investigated the correlation between vitamin D intake and 25-hydroxyvitamin D, interleukin-6, and ferritin levels in the maternal and umbilical cord.

Phytocannabinoids as Novel SGLT2 Modulators for Renal Glucose Reabsorption in Type 2 Diabetes Management.

: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have transformed type 2 diabetes mellitus (T2DM) management by promoting glucosuria, lowering glycated hemoglobin (HbA1c), blood pressure, and weight; however, their use is limited by genitourinary infections and ketoacidosis. Phytocannabinoids-bioactive compounds from -exhibit multi-target pharmacology, including interactions with cannabinoid receptors, Peroxisome Proliferator-Activated Receptors (PPARs), Transient Receptor Potential (TRP) channels, and potentially SGLT2. : To evaluate the potential of phytocannabinoids as novel modulators of renal glucose reabsorption via SGLT2 and to compare their efficacy, safety, and pharmacological profiles with synthetic SGLT2 inhibitors.

A Tradeoff Between the Escape from '-Mediated Resistance and Virulence in Pepper Mild Mottle Virus Through Reduced Virus Accumulation.

' resistance is intrinsically broken by tobacco mosaic virus but is still effective against pepper mild mottle virus (PMMoV), including those breaking resistance in peppers. To evaluate the durability of ' resistance to PMMoV, we performed random mutagenesis of the coat protein (CP) gene of PMMoV. We isolated 11 CP mutants with two to six amino acid changes that escaped the '-mediated resistance response in .

Analog Rice Based on Sago and Corn with the Addition of Moringa Leaf ( L.) Powder as a Nutritional Vehicle for Breastfeeding Women.

Breastfeeding women require specific nutrition to support the quality and secretion of breast milk, which can be achieved through the development of analog rice. Several potential alternatives to develop analog rice, including sago and corn flour, can be developed with the addition of moringa leaf powder due to its high nutritional composition and bioactive compounds, particularly high protein, iron, phytosterols, and flavonoids, which are suitable for breastfeeding women. However, as a new product, besides considering its nutritional value, developing the preferred and acceptable formulation of analog rice remains challenging.

The High Frequency of a G-Allele Variant of the Gene in Old Asian Cattle Breeds, Water Buffaloes, and Holstein Friesian Cows: A Potential Link to Infertility.

Reproductive failure in cattle production is a global concern and is influenced by various factors, including genetic alterations. This study explored the relationship between an X-linked single-nucleotide variant (NC_037357.1: g.

Efficacy and Safety of Coenzyme Q10 in Idiopathic Male Infertility: A Systematic Review and Meta-Analysis of Randomized Trials.

Purpose: Despite numerous studies on coenzyme Q10 (CoQ10) as a treatment for idiopathic male infertility (IMI), clear clinical guidance remains lacking. This systematic review and meta-analysis (SRMA) aimed to evaluate the efficacy of CoQ10 and determine the optimal dose, formulation, and treatment duration compared to placebo or other therapies.

Materials And Methods: We searched PubMed, Science Direct, and Cochrane Library using relevant keywords to identify studies assessing CoQ10's effects on sperm parameters, seminal CoQ10 levels, and clinical pregnancy rates in men with IMI.

Neonatal mortality and survival of low-birth-weight infants at hospitals in indonesia, a multi center study.

The first month of life is the most vulnerable period for child survival. Newborns who are born too soon or too small, or sick, are at the greatest risk of death. Objective of the study was to delve into neonatal mortality and low birth weight (LBW) survival at hospitals in Indonesia.

Comparative efficacy and safety of silodosin and tadalafil combination or monotherapy for treating lower urinary tract symptoms due to benign prostatic obstruction: A systematic review and meta-analysis.

Introduction: Over the last few years, trends in managing benign prostatic hyperplasia (BPH) have improved, advancing from reliance on surgery to satisfactory medical therapies. However, the efficacy and safety of combination therapies, including silodosin and tadalafil, are not well established compared to monotherapy for treating lower urinary tract symptoms (LUTS) due to benign prostatic obstruction (BPO).

Material And Methods: A systematic search was conducted in PubMed, ScienceDirect, Cochrane Library, and Scopus up to April 1, 2024.

Volatile pyrethroid spatial repellents for preventing mosquito bites: a systematic review and meta-analysis.

Background: Volatile pyrethroid spatial repellents (VPSRs) can prevent mosquito-borne diseases including malaria and dengue fever, but the use of varied evaluation methods has resulted in a lack of clarity regarding their protective efficacy (PE) against contact with mosquitoes. This systematic review and meta-analysis consolidates the entomological evidence base on the PE of VPSRs against Anopheles, Aedes, and Culex mosquitoes and different test methods used.

Methods: We identified studies completed between January 2000 and September 2023 by searching through databases, conference abstracts, and personal correspondences.

Evaluation of clinical research priorities in Asian intensive care units (ERA-ICU).

Background: Practice and delivery of critical care in Asia varies according to healthcare structure, income setting, and cultural factors. Identifying research priorities specific to ICU patients and healthcare workers in Asia is needed to guide advancement of critical care in the region.

Methods: This was an international cross-sectional survey study with adapted methods from nominal group techniques.

Epidemiological characteristics and pathogen profiles of non- gram-negative urinary tract infections in pregnant women: insights from Makassar, Indonesia.

Introduction: urinary tract infections (UTIs) during pregnancy pose significant health risks for both mother and fetus. While Escherichia coli is the most common causative agent, non-Escherichia coli gram-negative bacteria also contribute to UTIs, with their specific prevalence and characteristics in pregnant women needing further elucidation, particularly in local contexts. This study aimed to identify gram-negative non-Escherichia coli bacteria causing UTIs in pregnant women and to determine their epidemiological characteristics in Makassar, Indonesia.

Comparative safety and efficacy of invasive therapies for carotid artery stenosis: a systematic review and network meta-analysis.

Background: Carotid artery stenosis is a major cause of stroke and is commonly treated with carotid endarterectomy (CEA) or carotid artery stenting (CAS). Trans-carotid artery revascularization (TCAR) has emerged as a newer alternative designed to reduce the risk of procedural stroke. However, comparative evidence on the safety and efficacy of these interventions is limited.

Adaptation and validation of the Indonesian version of the early feeding skill assessment tool for low birth weight infants.

Initiating oral feeding at inappropriate times can cause stress and complications for Low Birth Weight (LBW) infants. It is essential to assess the infant's readiness for oral feeding to minimize stress and support the transition to full oral feeding. An objective assessment tool is necessary to improve the accuracy of determining the right time to start oral feedings.

A novel hybrid CLARA and fuzzy time series Markov chain model for predicting air pollution in Jakarta.

Air pollution poses a significant challenge to public health and the global environment. The Industrial Revolution, advancing technology and society, led to elevated air pollution levels, contributing to acid rain, smog, ozone depletion, and global warming. Poor air quality increases risks of respiratory inflammation, tuberculosis, asthma, chronic obstructive pulmonary disease (COPD), pneumoconiosis, and lung cancer.

Comparison of Clinical Outcomes of Thyroid Artery Embolization in the Treatment of Thyroid Nodules: A Meta-Analysis.

Objective: To compare the clinical outcomes of thyroid artery embolization (TAE) in the treatment of thyroid nodules.

Methods: A systematic review and meta-analysis were conducted following PRISMA guidelines. Relevant studies published between 1973 and 2023 were identified through PubMed, Cochrane Central, Web of Science, and Google Scholar.

The Ideal Second-Line Treatment Options for Patients with Advanced Biliary Tract Cancer Refractory to Gemcitabine-Based First-Line Chemotherapy: A Result From Bayesian Network-Meta Analysis.

Objective: To determine the most ideal second-line treatment for advanced biliary tract cancer, considering the response rate, survival, and drug adverse events.

Methods: This network meta analysis (NMA) was conducted in accordance with the PRISMA with NMA extension guidance. After formulation of PICO, comprehensive searches of literatures were done including all randomized controlled studies that reported the second-line treatment for advanced biliary tract cancers' subjects who have failed with first-line gemcitabine-based chemotherapy.

A Systematic Review And Meta-Analysis Comparing The Prognoses Of Benign Thyroid Nodules Using Radiofrequency Ablation Versus Lobectomy.

Background: The evolution of technology and medicine has allowed for a considerable number of alternatives for treating medical issues, particularly those requiring invasive surgery. Thyroid nodules consisting of abnormal benign tissue are conventionally managed with surgery (lobectomy); however, advancements have introduced radiofrequency ablation as a method to manage these nodules. The two interventions have shown similar efficacies and no conclusive determination has been reported that proves which method (if any) has the lower recurrence rate.

Harnessing the power of marine terpenoids against diabetes-associated oxidative stress.

Diabetes mellitus (DM), particularly type 2 diabetes (T2DM), remains a significant global health concern, driven largely by oxidative stress-induced damage. Marine terpenoids, bioactive compounds extracted from diverse marine organisms such as algae, sponges, and corals, present promising antioxidant and antidiabetic potential. This review systematically evaluates the chemical diversity, biological sources, and mechanisms of action of marine terpenoids in mitigating diabetes-associated oxidative stress.

Development of family readiness instrument for caring of stroke patients at home: Application of transition theory.

Background: Lack of family readiness to care for stroke patients can negatively impact the health of family members who serve as primary caregivers, often leading to prolonged stress and depression.

Aim: This study aimed to develop a valid and reliable family readiness instrument based on a transition model to assess preparedness for caring for stroke patients at home.

Methods: A mixed-methods approach was employed in this research, consisting of four phases: Delphi Study, face validity, content validity, and testing for structural validity and reliability.

Anti-cancer activity of Ajwa Dates extract ( L.) through analysis of MCL-1 levels, EGFR, and p53 expressions on apoptosis in human prostate cancer cell lines PC3: an study.

Introduction & Objectives: Prostate cancer is recognized as a global burden disease related to malignancy in men. Several fruit and plant-based supplementation have been studied to evaluate their utility for the management of prostate cancer. Ajwa dates (Phoenix Dactylifera L.

Native vs. synthetic grafts in lower extremity vascular trauma: Lessons from two rural case presentations.

Introduction: Trauma to the extremities is a common injury that demands a comprehensive evaluation of vascular structures. Prompt identification and timely intervention improve clinical outcomes; severe injuries frequently lead to complications and potential limb loss. Revascularization delays greater than 8 h post-injury markedly increase amputation risk.

Carotenoid and peptide supplementation from Caulerpa sp. (sea grapes) extract mitigate metabolic syndrome in cholesterol-enriched diet rats via modulation of gut microbiota.

Background: Metabolic syndrome (MetS) is a multifactorial disorder characterized by obesity, dyslipidemia, insulin resistance, and hypertension, increasing the risk of cardiovascular diseases and type 2 diabetes mellitus (T2DM). Recent evidence suggests that gut microbiome dysbiosis plays a significant role in MetS pathogenesis. Functional foods enriched with bioactive compounds, particularly those derived from marine sources, have emerged as promising interventions.