Novel Splice Variant in the Gene in Vietnamese Patient with Spondylocostal Dysostosis 4: A Case Report and Literature Review.

Spondylocostal dysostosis (SCDO) is a group of rare genetic disorders characterized by segmental vertebral defects and rib deformities due to congenital misalignment, fusion, or reduction in the number of ribs. The causes of the disease have been found in seven genes, including (SCDO1, OMIM 602768), (SCDO2, OMIM 608681), (SCDO3, OMIM 609813), (SCDO4, OMIM 608059), (SCDO5, OMIM 602427), (SCDO6, OMIM 616566), and (SCDO7). Among these, SCDO4, characterized by a short trunk, short neck, and mild nonprogressive scoliosis, is a rare form of reported cases.

New records and an updated checklist of the herpetofauna from Tay Yen Tu Nature Reserve, north-eastern Vietnam.

Background: The Tay Yen Tu Nature Reserve is situated on the western side of the Yen Tu Mountain Range in Bac Giang Province, northern Vietnam. Since its establishment in 2002, several studies on the herpetofauna of this protected area have been carried out. For example, Nguyen et al.

Diet of Critically Endangered Black-Eyed Bent-Toed Gecko, , Nguyen, Orlov & Darevsky, 2006 From Vietnam.

The Black-eyed Bent-toed Gecko, , a species endemic to Ba Den Mountain Cultural and Historical Complex, Tay Ninh Province, Vietnam, has been classified as Critically Endangered in the IUCN Red List since 2018. However, knowledge of its natural history is virtually non-existent. To fill this gap, the diet of the gecko was studied by stomach flushing.

Immunoregulation of Quercetin and Kynurenic Acid on Human Umbilical Cord Mesenchymal Stem Cells Through Gene Expression of Aryl Hydrocarbon Receptor and Interleukin-6 in Hyperglycemic Milieu.

Mesenchymal stem cells (MSCs) exhibit great promise for treatment applications because of their immunosuppressive properties. The aryl hydrocarbon receptor (AHR), which is a transcription factor that is activated via ligand, has a pivotal role in regulating the immune system and is involved in a range of immune-related disorders. However, hyperglycemia, the defining biochemical hallmark of diabetes, creates a chronically pro-inflammatory microenvironment that impairs the immunoregulatory effects of MSCs.

Integration of magnetic graphene oxide and office waste paper-derived fibrillated cellulose into a composite adsorbent for effective tetracycline elimination.

Utilizing office waste paper for environmental treatments has garnered significant interest from the research community, as it addresses both waste management and the development of low-cost sustainable adsorbents. In this study, a novel approach was developed by integrating office waste paper-derived fibrillated cellulose (PFC) with magnetic graphene oxide (M-GO) to develop a composite adsorbent for the removal of tetracycline (TC) from aqueous solutions. PFC was isolated an alkali-acid treatment process; graphene oxide (GO) was synthesized using a modified Hummers' method and subsequently functionalized with magnetite nanoparticles to produce M-GO.

High accumulation of Po concentration in muscle tissue and hepatopancreas gland organs of Asian green mussel (Perna viridis) at the coastal area of Binh Thuan, Vietnam: Radiological protection perspectives.

Po (polonium) has high radiotoxicity that tends to accumulate in marine bivalves inhabiting coastal zones with elevated background levels of primordial radionuclides. In this study, the Po concentration in two organs of the Asian green mussel (Perna viridis), collected from the coastal region of Binh Thuan, Vietnam, was determined using alpha spectrometry. The results showed a significant difference in Po activity concentration between the two organs of P.

(Marchantiopsida) Penetrates the Paleotropics.

East Asian is the only representative monotypic Monosoleniaceae and has been found for the first time in North Indochina in five provinces of Vietnam. All paleotropical localities, including those previously known in Indonesia, are situated not in the high mountains, as one might expect for the East Asian species occurring southward in East Asia, but in the lower altitude zones (i.e.

Targeting SARS-CoV-2 RNA-dependent RNA polymerase with the coumarin derivative BPR2-D2: Evidence from cell-based and enzymatic studies.

The rapid mutation rate of SARS-CoV-2 highlights the urgent need for continuous drug development to enhance both efficacy and safety. BPR2-D2, an angular coumarin derivative, has previously shown notable anti-influenza activity and broad-spectrum inhibitory effects against RNA viruses. In this study, we found that BPR2-D2 exhibits potent antiviral activity against multiple SARS-CoV-2 variants, including several variants of concern, at nanomolar concentrations.

Graphene oxide-carbon nanotube-magnetite nanocomposites for efficient arsenic removal from aqueous solutions.

In this study, graphene oxide-carbon nanotube-magnetite (GO/CNT/FeO) nanocomposites were synthesized a co-precipitation method for wastewater treatment. The obtained results indicated that FeO nanoparticles exhibited a spherical-shaped morphology, with an average diameter of around 20 nm, and decorated the surface of GO and CNTs. The adsorption data fitted well with the Langmuir isothermal model, exhibiting a coefficient of > 0.

Phthalic acid esters (PAEs) in surface water from five tropical estuaries: Spatial distribution, seasonal variations, and mass loads.

Information about the occurrence of phthalic acid esters (PAEs) in water environments in Vietnam and Southeast Asia is still limited. In this study, we analyzed ten PAEs in surface water samples collected from five estuaries in Thanh Hoa Province, central Vietnam, to elucidate pollution levels and patterns, seasonal variations, potential sources, and mass loads of these typical pollutants in tropical estuarine regions. Concentrations of total PAEs ranged from 663 to 4782 ng/L, with higher levels found in the dry season (median 2747; range 1267-4782 ng/L) than in the rainy season (1493; 663-3512 ng/L).

Taxonomic revision of the complex (Amphibia, Dicroglossidae) in Vietnam, with descriptions of two new species.

This study provides a taxonomic revision of the complex in Vietnam. Based on integrative taxonomic analyses, sensu stricto is distributed in Lao Cai, Vinh Phuc, Ha Giang, and Tuyen Quang provinces. Other records of in northern and central Vietnam revealed to be representatives of two new species: from Son La, Thanh Hoa, and Nghe An provinces and from Quang Binh and Thua Thien Hue provinces.

Tailoring morphological and electrical properties of nanoplate-ZnO varistors sintering temperature.

In this study, ZnO nanoplates (crystallite size: 100 nm, thickness: 15 nm) were synthesized a hydrothermal route. Varistors were then fabricated using these ZnO nanoplates incorporated with five oxide dopants (BiO, SbO, MnO, CoO, and CrO) and sintered at 1000, 1100, and 1200 °C. A control varistor sample using micro-sized ZnO was also prepared.

A facile fabrication method of sericin/chitosan film without additives for fruit coating.

Sericin (SS) serves as a natural adhesive, binding silk fibers within the silkworm cocoon and shielding them from environmental stresses. Commonly, SS-based films rely on additives to improve their physical properties. In this study, we developed an additive-free film composed of SS and chitosan (CS) in an ethanol environment, achieving enhanced tensile strength, elongation at break, and water retention and release capacity through structural modification of SS.

Ultrasmall Bi/BiO nanoparticles as biocompatible and efficient CT imaging contrast agents.

Computed tomography (CT) imaging is a widely used diagnostic tool, but conventional iodine-based contrast agents suffer from limitations such as short circulation time and potential nephrotoxicity. In this study, we present a simple one-pot thermal decomposition method for synthesizing ultrasmall Bi/BiO nanoparticles (NPs) using a commercial Bi(NO) precursor and a surfactant mixture of oleic acid and oleylamine. Oleylamine acts as a reducing agent, facilitating the conversion of Bi to metallic Bi, while the BiO oxide layer is controlled by adjusting the oleic acid-to-oleylamine ratio.

A new ursane-type triterpene and potent antibacterial alkylbenzoquinones from the aerial parts of .

A new ursane-type triterpene () alongside two known alkylbenzoquinones, dihydromaesanin () and embeliquinone (), were isolated from the aerial parts of . The structure of was elucidated based on 1D-, 2D-NMR, and HRESI-MS data. The two alkylbenzoquinones were tested on 13 phytopathogenic bacterial strains.

Antibacterial and electrical performance of triboelectric nanogenerators based on polyhexamethylene guanidine hydrochloride in high humidity environments.

A humidity-resistant, antibacterial triboelectric nanogenerator (TENG) was developed using polyhexamethylene guanidine hydrochloride (PHMG) as the primary functional material. To enhance performance stability, PHMG was integrated with natural chitosan (CS) to create a positively charged triboelectric electrode. When combined with a negatively charged fluorinated ethylene propylene (FEP) membrane, the TENG demonstrated outstanding electrical output, achieving a maximum peak-to-peak voltage ( ) of 1470.

Radioactive concentrations and natural radionuclide risks in Ha Long Bay and Ba Che Estuary sediments, Vietnam.

Near the coast, the Ba Che Estuary and Ha Long Bay are influenced by both natural processes and man-made activities. The radioactive contents of Ra,  K, and Th and the radiation risk indices of nine sediment cores were determined to assess the impact of radiation on the environment and humans. The  K, Th, and Ra had average radioactivity concentrations of 383, 41.

Ethnopharmacological and scientific validation of Caryota mitis Lour fruit peel for osteoarthritis and gout management.

Ethnopharmacological Relevance: Traditional medicine in Vietnam has long utilized Caryota mitis Lour fruit peel to relieve joint pain, back pain, and inflammation. Despite its widespread use, scientific validation of its therapeutic effects remains limited. The application of the fruit peel in disease treatment is largely based on anecdotal evidence, highlighting the need for rigorous scientific research to substantiate its efficacy and elucidate its mechanisms of action.

Genetic and Antigenic Diversity of Serogroup B Strains in Vietnam.

Background: () is a leading cause of acute meningitis and is classified into 13 serogroups, six of which are predominantly associated with invasive meningococcal disease. This study aimed to investigate the genotype, subgenotype, and antigenic profiles of serogroup B strains isolated in Vietnam.

Methods: Genotyping was performed on 106 strains isolated from clinical samples from Vietnamese patients and nasopharyngeal of healthy adolescents between 2019 and 2024.

Toward a Kinh Vietnamese Reference Genome: Constructing a De Novo Genome Assembly Using Long-Read Sequencing and Optical Mapping.

Population-specific reference genomes are essential for improving the accuracy and reliability of genomic analyses across diverse human populations. Although Vietnam ranks as the 16th most populous country in the world, with more than 86% of its population identifying as Kinh, studies specifically focusing on the Kinh Vietnamese reference genome remain scarce. Therefore, constructing a Kinh Vietnamese reference genome is valuable in the genetic research of Vietnamese.

Anti-inflammatory effects and HPLC-PDA quantification of the triterpene saponin-enriched extract of leaves.

For the first time, the anti-inflammatory activity against Nitric oxide (NO) overproduction Lipopolysaccharide (LPS) injection on RAW264.7 cells as well as the quantitative determination of triterpene saponin-enriched extract from the leaves (SE-CTL) High-Performance Liquid Chromatography (HPLC) using Photodiode Array Detector (PDA) technique was investigated. The SE-CTL significantly exhibited the best inhibition of NO (IC value of 46.

Therapeutic effects of and its active compound eupatilin in rheumatoid arthritis: and validation.

The 50% ethanol extract of the aerial parts of (CZ extract) was evaluated for its inhibitory effects on the production of NO, TNF-α, and XO, and seven isolated flavonoids were tested for COX-2 inhibitory activity. The ethanol extract of exhibited a strong inhibitory effect on NO and XO overproduction, with IC values of 6.91 µg/mL and 83.

Preparation and synergistic effect of aluminum hydroxide nanoplates on the fire resistance and thermal stability of the intumescent flame retardant epoxy composite.

Aluminum hydroxide nanoplates (nATH), with an average particle size of about 350-450 nm and a thickness of 30 nm, were successfully synthesized through a hydrothermal process using an Al(OH) gel precursor. The ATH nanoplates were then surface-treated with organic compounds and incorporated into an intumescent flame-retardant epoxy system containing polyethyleneimine-modified ammonium polyphosphate (APP@PEI). Among them, the combination of APP@PEI and PEI-treated nATH (nATH) exhibited the highest synergistic effect on the fire resistance and thermal stability of epoxy resin due to the superior dispersion of the nanoplates.

Complete genome of sp. HP10 isolated from the gastrointestinal tract of farmed shrimp.

The complete genome sequence of strain HP10, which was isolated from the gastrointestinal tract of whiteleg shrimp, is presented here. The bacterium has one chromosome (4.17 Mb), one plasmid (62.

Chitosan-Polymer Conjugates as Functional Coatings for Liposomal Bioactive Delivery Systems.

Conventional liposomes hold promise as drug delivery systems but face challenges such as susceptibility to rapid clearance and limited targeting specificity. To address these limitations, polymer-coated liposomes have emerged as a viable solution, offering improved biocompatibility and targeted delivery capabilities. This study reports the synthesis and application of a chitosan-polyethylene glycol-folic acid (CTS-PEG-FA) conjugate as a functional liposome coating.