Nanoemulgel mediated enhanced skin curcumin penetration/retention for local treatment of cutaneous leishmaniasis: and assessment.

Background: Skin delivery of a therapeutically effective drug is imperative for local cutaneous leishmaniasis (CL) treatment.

Objective: This study aimed to formulate, optimize, and characterize curcumin-loaded nanoemulgel for enhanced skin drug retention to treat CL locally.

Methods: Nanoemulsions were prepared by high-speed homogenization, characterized, and optimized for size, PDI, zeta potential, stability, morphology, drug contents, encapsulation efficiency, drug release, antileishmanial activity, and cell viability.

Computational investigation to identify multi-targeted anti-hyperglycemic potential of substituted 2-Mercaptobenzimidazole derivatives and synthesis of new α-glucosidase inhibitors.

One of the most widespread diseases recognized all over the world is diabetes, accounting for 1.5 million deaths each year. Recent studies have demonstrated benzimidazole derivatives as potential antidiabetic agents.

Emerging challenges in Klebsiella pneumoniae: Antimicrobial resistance and novel approach.

Klebsiella pneumoniae poses significant global health challenges due to its increasing antimicrobial resistance (AMR). The emergence of multidrug-resistant (MDR) and carbapenem-resistant strains has limited treatment options, making infections difficult to control. This pathogen utilizes several mechanisms, including extended-spectrum β-lactamase (ESBL) production and efflux pumps, contributing to its resistance.

Knowledge, attitudes, and practices toward leishmaniasis and one health: a cross-sectional study among medical and veterinary professionals.

Leishmaniasis is a significant zoonotic infection with global health implications, particularly in regions where human and animal health are closely interconnected. This cross-sectional study assessed the knowledge, attitudes, and practices (KAP) of 5,074 participants regarding leishmaniasis and the One Health concept. The socio-demographic data revealed that most respondents were young (82.

Anti-inflammatory, antidiabetic and hypolipidemic potential of Cinnamomum verum J. Presi bark coupled with FT-IR and HPLC analysis.

Medicinal plants and herbs are used from ancient times for the treatment of acute or chronic diseases because they are easily accessible and have low cost. In this research, we investigated anti-inflammatory, hypoglycemic and hypolipidemic potential of ethanolic extract of Cinnamomun verum J. Presi bark.

Local and global stability analysis of HIV/AIDS by using a nonstandard finite difference scheme.

This study presents a mathematical model incorporating both asymptomatic and symptomatic HIV-infected individuals to analyze the dynamics of HIV/AIDS. This expanded model offers a more comprehensive understanding of the epidemic's spread. We calculate the basic reproduction number (R) to quantify the virus's transmission potential.

Synergistic effects of zP-1 phage and ampicillin against methicillin-resistant Staphylococcus aureus isolated from hospital staff.

Background: Methicillin-resistant Staphylococcus aureus (MRSA) strains are a major cause of hospital-acquired infections, exacerbated by increasing antibiotic resistance.

Aim: This study aimed to isolate bacteriophages targeting MRSA and evaluate their antimicrobial activity in combination with antibiotics.

Methods: Nasal samples from hospital staff (n = 50) were used to isolate MRSA strains, and sewage samples were processed for phage isolation using the double agar overlay technique.

Mitigation of salinity stress in sunflower plants ( L.) through topical application of salicylic acid and silver nanoparticles.

Salinity stress poses a significant threat to sunflower ( L.) by impairing water and nutrient uptake, disrupting cellular functions, and increasing oxidative damage. This study investigates the impact of Salicylic acid (SA) and silver nanoparticles (AgNPs) on growth, biochemical parameters, and oxidative stress markers in salt-stressed sunflower plants.

Synthesis of novel magnesium ferrite Schiff base chitosan nanocomposite for efficient removal of pb(II) ions from aqueous media.

In this study, a novel MgFeO-Schiff base-chitosan nanocomposite was synthesized using a straightforward crosslinking method. The synthesis involved integrating MgFeO nanoparticles with modified chitosan through a Schiff base formed by the reaction between terephthalaldehyde and aminopyrazine. A comprehensive characterization was performed, including X-ray diffraction analysis, which verified the crystalline structure and the successful incorporation of MgFeO nanoparticles into the chitosan-Schiff base matrix.

Correction: Rehman et al. Fabrication, In Vitro and In Vivo Assessment of Eucalyptol-Loaded Nanoemulgel as a Novel Paradigm for Wound Healing. 2022, 1971.

In the original publication, there was a mistake in Figure 4 as published [...

Evaluating Forelimb and Hindlimb Joint Conformation of Morna Racehorses ().

Measuring limb joint angles is crucial for understanding horse conformation, performance, injury diagnosis, and prevention. While Thoroughbred horses have been extensively studied, local Pakistani breeds (e.g.

Retraction Note: Mathematical analysis of COVID-19 pandemic by using the concept of SIR model.

[This retracts the article DOI: 10.1007/s00500-021-06133-1.].

A customized convolutional neural network-based approach for weeds identification in cotton crops.

Smart farming is a hot research area for experts globally to fulfill the soaring demand for food. Automated approaches, based on convolutional neural networks (CNN), for crop disease identification, weed classification, and monitoring have substantially helped increase crop yields. Plant diseases and pests are posing a significant danger to the health of plants, thus causing a reduction in crop production.

Synergistic effects of Vachellia nilotica-derived zinc oxide nanoparticles and melatonin on drought tolerance in Fragaria × ananassa.

This study investigates the synergistic effects of zinc oxide nanoparticles (ZnO NPs) and melatonin (MT) on Fragaria × ananassa (strawberry) plants under drought stress, focusing on growth, fruit biomass, and stress tolerance. ZnO NPs enhance nutrient uptake and stress resistance, while MT regulates growth hormones and boosts photosynthetic efficiency. Seven treatments were evaluated: T1 (no stress, 0.

Pharmacist-led antibiotic interventions in infectious disease patients: a Pakistani tertiary care antimicrobial stewardship study.

Background: Antibiotics are widely used medications among infectious disease patients; therefore, proper monitoring and assessment are critical for ensuring rational use. Antimicrobial stewardship addresses the rational and appropriate use of antibiotics, which reinforces overall health outcomes. Ongoing antimicrobial resistance scenarios are an alarming condition for healthcare, necessitating continued practice of such assessments.

Clinical and molecular analysis of ESBL, carbapenemase, and colistin-resistant bacteria in UTI patients.

Uropathogens, particularly bacteria, can infect any part of the urinary tract and cause bacteriuria. Our study aimed to examine the antibiotic-resistant profile, associated risk factors, and phenotypic and genotypic features of ESBL, carbapenemase, and mcr resistance genes in multidrug-resistant bacteria. Samples were inoculated on culture media, identified using standard biochemical tests, and species confirmation was performed via 16S rRNA gene amplification.

Fabrication of glipizide loaded polymeric microparticles; in-vitro and in-vivo evaluation.

Controlled-release microparticles offer a promising avenue for enhancing patient compliance and minimizing dosage frequency. In this study, we aimed to design controlled-release microparticles of Glipizide utilizing Eudragit S100 and Methocel K 100 M polymers as controlling agents. The microparticles were fabricated through a simple solvent evaporation method, employing various drug-to-polymer ratios to formulate different controlled-release batches labeled as F1 to F5.

Quinoline: A Novel Solution for Next-Generation Pesticides, Herbicides, and Fertilizers.

Quinoline is a nitrogen-containing heterocycle compound widely used in the medical industry for its pharmacological properties, such as its antimalarial, antimicrobial, antiparasitic, anti-inflammatory, and anticancer activities. Beyond its medical significance, quinoline shows promising applications in agriculture as a safe and effective pesticide, herbicide, and fertilizer. This review explores the evolution of quinoline research, beginning with its history and synthesis and transitioning to its biological activities and their relevance in agriculture.

Advance Glycation End Products Inhibition by Peel Extract; Characterization, LCMS-QTOF Analysis, and Biological Evaluation.

Advance glycation end products (AGEs) are the main reason for diabetic complications. Persistent hyperglycemia and non-enzymatic glycation increase the rate of AGEs formation. Natural functional food-based approaches are mainly under investigation these days to discover new treatment options.

Fabrication and evaluation of chondroitin sulfate based hydrogels loaded with chitosan nanoparticles for oral delivery of vildagliptin.

Vildagliptin is a drug of choice in type II diabetes mellitus that suffers from limitations like short half-life with reduced bioavailability. To improve the therapeutic performance of vildagliptin, this study aimed to synthesize chitosan nanoparticles (NPs) loaded hydrogel by using biological polysaccharides like sodium alginate (SA) and chondroitin sulfate (CS). The NPs were prepared by ionic gelation method and various characterization tests like surface morphology, size and zeta potential, entrapment efficiency, and in-vitro drug release studies were performed.

Assessment of growth, biomass, and carbon sequestration potential of urban tree species in greenbelts.

This study assessed the growth, biomass, and carbon storage potential of four urban tree species-Pinus roxburghii, Broussonetia papyrifera, Jacaranda mimosifolia, and Eucalyptus camaldulensis-in Islamabad's greenbelts. Sampling was conducted using a quadrat method, covering five sites (F-9, G-8, H-8, I-8, Zero-Point), with 400 trees analyzed. Growth parameters such as diameter at breast height (DBH), height, aboveground biomass (AGB), aboveground carbon density (ACD), belowground carbon density (BCD), basal area (BA), and volume were measured.

Burden of neurodevelopmental disorder in Lakki Marwat population of Khyber Pakhtunkhwa, Pakistan.

Background: Pakistan is a multi-cultural country with different ethnic groups living in both rural and urban communities. There is a significant occurrence of congenital and hereditary neurodevelopmental disorder (NDD) contributing to mortality and morbidity rates.

Objectives: This study aims to explore the prevalence, patterns, and phenotypic spectrum of NDD in district Lakki Marwat population of Khyber Pakhtunkhwa, Pakistan.

Correction: Habib et al. Thiolated Chitosan Microneedle Patch of Levosulpiride from Fabrication, Characterization to Bioavailability Enhancement Approach. 2022, , 415.

In the original publication [...