Hydroxyl radical-initiated degradation kinetics of organic pollutants in surfactant-rich environments.

Surfactant-rich aqueous media are common in natural environments. The sea surface microlayer and sea spray droplets are good examples and are also frequently markedly enriched in organic pollutants. This study focuses on the degradation kinetics of organic pollutants initiated by the hydroxyl radical in such surfactant-rich environments.

Immune intervention is dispensable for retinoic acid/arsenic therapy of murine acute promyelocytic leukemia.

Not available.

Hyperpolarized NMR Combined with Quantum Mechanical Simulations Reveal Atomistic Structures of Calcium Phosphate Prenucleation Clusters.

The discovery of solute precursors of crystalline materials, such as biominerals, recently challenged the classical nucleation theory (CNT). One emerging method for investigating these early-stage intermediates in solution is dissolution dynamic nuclear polarization (dDNP)-enhanced nuclear magnetic resonance (NMR) spectroscopy. Recent applications of dDNP to calcium carbonate (CaC) and calcium phosphate (CaP) mineralization have demonstrated the feasibility of identifying and tracing very early-stage prenucleation clusters (PNCs).

Strategic advances in C-OCF bond transformations.

While synthetic developments for the synthesis of trifluoromethoxylated arenes have flourished over the years, the cleavage of a C-OCF bond remains a niche topic and a synthetic challenge to overcome. This review provides an overview of major advances made in activating a strong aryl C-OCF bond, enabling C-C, C-H, and C-Heteroatom bond formations. These advances underscore the transformative potential of further developments in this emerging field.

In Vitro Evaluation of the Effects of Multipoint Hyaluronic Acid-Based Intradermal Fillers on Skin Quality Using a Novel 3D Reconstructed Skin Aging Model.

Background: Superficial injection of hyaluronic acid (HA)-based gels is a widely used method to restore skin quality and achieve a more youthful appearance. While the clinical benefits of such procedures are well established, their biological mechanisms of action remain poorly understood.

Objective: This study aimed to evaluate the effectiveness of two cross-linked HA gels (IPN-12.

Age-Related Differences in Jumping and Sprinting Performance and Force Production Capacities in Young Soccer Players.

The purpose of this study was to evaluate the evolution of jump and sprint force-production capacities with maturation in young soccer players. One hundred sixteen young elite male soccer players aged 11-17 years were assigned to six different groups according to their maturity status. The force-velocity (F-V) profiles in jumping and sprinting performances were compared among groups.

[Biomarkers for an early detection of patients at risk of renal or cardiovascular disease].

Chronic kidney disease (CKD), heart failure (HF) and atherosclerotic cardiovascular disease (ASCVD) are pathologies that may remain silent for a long time and thus are largely underdiagnosed in clinical practice. The use of biomarkers may help detect people already suffering from these diseases at an early stage or at increased risk to develop them in a near future. The aim of this article is to discuss the place of the assays of albuminuria, natriuretic peptide (BNP/proBNP) and high-sensitivity troponin as well as lipoprotein(a) to help in the diagnosis and prognosis assessment of individuals at risk of presenting or developing a CKD, HF or ASCVD.

Spin crossover particle shielding upon grinding in thermoplastic polyurethane composites.

Ball milling experiments were conducted on spin crossover (SCO) powder and SCO@polyurethane composite samples. The study reveals that the presence of the TPU matrix acts as a shield for the SCO particles upon grinding, precluding their deactivation. This result is encouraging for the integration of SCO materials into devices.

Targeted 'infectiosome' for disease ecology: A new tool to answer old questions.

Research Highlight: Bralet, T., Aaziz, R., Tornos, J.

Real-World Evaluation of Botulinum Toxin A in Focal Peripheral Neuropathic Pain: Longitudinal Outcomes.

Background: Neuropathic pain (NP) is frequently resistant to conventional treatments. Botulinum toxin type A (BT-A) is a recommended option for focal peripheral NP, but the dynamics of its effect in real-life conditions remain poorly characterized.

Objective: To assess BT-A efficacy in a real-world study of patients with focal peripheral NP, over a 1-year follow-up period.

Development of a lip colour chart across four ethnicities.

In the human face, the lips play a key role in social interactions and are a major element of makeup strategies. However, the amount of data available on lips, particularly relating to colour, is limited in comparison to that on skin. To gain a better understanding of lip colour, this study aimed to assess its diversity across four ethnicities (Asian Chinese, African American, Hispanic American and Caucasian American and French).

Bacterial porphyrins in healthy skin: Microbiota components impact melanogenesis and age-related processes leading to Porphyr'ageing.

Objective: Porphyrins are ubiquitous metabolites and are constitutive of the bacterial metabolome of healthy skin. Their consideration has until now been limited to their pro-inflammatory activity in acne vulgaris. The present work suggests a new role for these molecules in the onset of skin ageing.

Quantifying the Environmental and Food Biodiversity Impacts of Ultra-Processed Foods - Evidence from the EPIC Study.

Objective: While associations of ultra-processed food (UPF) consumption with adverse health outcomes are accruing, its environmental and food biodiversity impacts remain underexplored. This study examines associations between UPF consumption and dietary greenhouse gas emissions (GHGe), land use, and food biodiversity.

Design: Prospective cohort study.

Bridging the knowledge gap: a mixed-methods study on general practitioners' information needs for mHealth apps in hypertension treatment in Germany.

Background: Hypertension remains a critical public health issue in Germany, affecting millions of individuals. Mobile health applications (mHealth apps) offer promising solutions for improving patient outcomes and adherence in hypertension management. Despite their advantages in healthcare, the adoption of mHealth apps by general practitioners (GPs) in Germany remains limited to date.

LONP1 Variants Are Associated With Clinically Diverse Phenotypes.

LONP1 encodes a mitochondrial protease essential for protein quality control and metabolism. Variants in LONP1 are associated with a diverse and expanding spectrum of disorders, including Cerebral, Ocular, Dental, Auricular, and Skeletal anomalies syndrome (CODAS), congenital diaphragmatic hernia (CDH), and neurodevelopmental disorders (NDD), with some individuals exhibiting features of mitochondrial encephalopathy. We report 16 novel LONP1 variants identified in 16 individuals (11 with NDD, 5 with CDH), further expanding the clinical spectrum.

A Promising Frontier in Cancer Therapy - Combining Endothelial Colony Forming Cells, Nanotechnology, and Hyperthermia for Precision Oncology.

Endothelial Colony-Forming Cells (ECFCs) are recognized as key vasculogenic progenitors in humans and serve as valuable liquid biopsies for diagnosing and studying vascular disorders. In a groundbreaking study, Anceschi et al. present a novel, integrative strategy that combines ECFCs loaded with gold nanorods (AuNRs) to enhance tumor radiosensitization through localized hyperthermia.

The value of optical genomic mapping in a patient with azoospermia and a complex chromosomal rearrangement.

Introduction: Complex chromosomal rearrangements (CCRs) are frequently associated with infertility and have been described in the literature. Chromoanagenesis corresponds to a group of CCRs with a high number of chromosome breakpoints. These CCRs involving small structural variations can only be identified by using high-resolution genomic techniques.

Exploratory Assessment of Preoperative GLP-1 Receptor Agonists Before Sleeve Gastrectomy: A Retrospective Matched Analysis.

Background: Preoperative treatment with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) before bariatric surgery has not been studied. Therefore, we investigated the impact of neoadjuvant treatment with GLP-1 RAs on weight loss and postoperative outcomes in patients who underwent sleeve gastrectomy for severe obesity.

Method: A retrospective single-center study was conducted between January 2022 and December 2023.

A comprehensive guide to digital neurology. An update on current development on digital neurology derived from the Digital Neuro Hub project.

The rapid evolution of digital tools in recent years after COVID-19 pandemic has transformed diagnostic and therapeutic practice in neurology. This shift has highlighted the urgent need to integrate digital competencies into the training of future specialists. Key innovations such as telemedicine, artificial intelligence, and wearable health technologies have become central to improving healthcare delivery and accessibility.

From semantic knowledge to semantic features: French semantic feature production norms for 360 concepts.

This article presents a new set of semantic feature production norms, collected from 580 young adults, for 360 French concepts across various semantic categories. Although empirically derived feature norms have been developed for several languages and have been shown to be useful for investigating semantic memory and providing assessment tools, none are currently available for native French-speaking populations. In this study, the participants performed a property generation task in which they were asked to list features to describe the characteristics of each given concept (e.

Blood loss and prolonged air leak reduction by applying TenaTac gelatine patch after major pulmonary minimal-invasive resection.

Objective: Reduction of bleeding and prolonged air leak (>5 days) following major lung resection remains a challenge. Hemostasis and aerostasis devices can facilitate earlier pleural de-drainage and fast-track. Our objectives were to evaluate the efficacy of TenaTac (an elastic, adhering patch approved as a medical device) in reducing bleeding and prolonged air leak after major lung resection.

Algorithm to detect ISUP ≥ 2 prostate cancer using canine detection.

Purpose: Screening and diagnosing ISUP ≥ 2 prostate cancer is challenging. This study aimed to determine whether canine detection could be beneficial addition to the ISUP ≥ 2 prostate cancer diagnostic protocol by creating a decision-making algorithm for men with suspected prostate cancer.

Methods: We conducted a prospective study at two urology institutions and a French veterinary school, including men with a suspicion of prostate cancer from November to April 2023, which were divided into two groups according to their prostate biopsy results.

CLEM-Reg: an automated point cloud-based registration algorithm for volume correlative light and electron microscopy.

Volume correlative light and electron microscopy (vCLEM) is a powerful imaging technique that enables the visualization of fluorescently labeled proteins within their ultrastructural context. Currently, vCLEM alignment relies on time-consuming and subjective manual methods. This paper presents CLEM-Reg, an algorithm that automates the three-dimensional alignment of vCLEM datasets by leveraging probabilistic point cloud registration techniques.

Systematic attribution of heatwaves to the emissions of carbon majors.

Extreme event attribution assesses how climate change affected climate extremes, but typically focuses on single events. Furthermore, these attributions rarely quantify the extent to which anthropogenic actors have contributed to these events. Here we show that climate change made 213 historical heatwaves reported over 2000-2023 more likely and more intense, to which each of the 180 carbon majors (fossil fuel and cement producers) substantially contributed.