Effectiveness and challenges of digital tools implementation for enhancing infectious disease surveillance data quality in low- and middle-income countries: A systematic review protocol.

Background: Monitoring infectious diseases is essential for preventing and controlling outbreaks, especially in low- and middle-income countries (LMICs), where issues like poor infrastructure, lack of trained staff, and limited resources can make data collection challenging. Digital tools such as mobile health apps and electronic reporting systems show promise in addressing these problems. However, it's still unclear how well these tools actually improve the quality of data, like how quickly information is reported, how accurate it is, whether all necessary data is captured, and if the data can be trusted.

Multilevel systems biology analysis identifies key immune response profiles and potential correlates of protection for M72/AS01E vaccine against tuberculosis.

Purpose: Tuberculosis (TB) claims around 1.5 million lives annually. The M72/AS01E vaccine candidate is an innovative effort demonstrating a 50% reduction in the incidence of active TB in adults.

Pharmacophoric analogs of Savolitinib reveal promising inhibitors of the c-MET receptor tyrosine kinase for drug discovery: in silico investigation.

The c-MET receptor tyrosine kinase has become a key focus for therapeutic intervention in various cancer types due to its crucial role in driving cancer progression and metastasis. While Savolitinib, a specific inhibitor of c-MET, has demonstrated promise in clinical trials, its limited availability within the body and the risk of developing resistance have prompted a quest for alternative inhibitors. In this research endeavor, we downloaded and screened a range of pharmacophoric analogs inspired by Savolitinib to explore new avenues for inhibiting c-MET.

Omega-3 fatty acids improves tamoxifen-induced sexual dysfunction in male Wistar rats by modulating NO/cGMP signaling and monoamine neurotransmitters activities.

Introduction: Tamoxifen (TAM) is an off-label treatment option for men with breast cancer, infertility, and gynecomastia. Unfortunately, one of the undesirable effects of TAM is sexual dysfunction. Therefore, this study was designed to investigate the possible associated mechanisms with TAM-induced sexual dysfunction and the possible ameliorative effect of omega-3 fatty acids (O3FA).

The Effect of Vitamin D3 supplementation on Flunitrazepam-Induced testicular dysfunction in Wistar rats.

Prolonged flunitrazepam use has been reported to be increasing among young adolescents, and it has been reported to induce hyperprolactinemia, causing gross impairment of testicular function, ultimately resulting in male infertility. Hence, this current study seeks to examine the possible protective potential of the micronutrient Vitamin D3 in mitigating flunitrazepam-induced testicular dysfunction. Adult male rats (Wistar strain), weighing 200-220 g, were categorized into four groups: Vehicle [0.

Green synthesized antimicrobial peptides and nanoparticles from Phoenix dactylifera: Evaluation of anti-biofilm, anti-pathogenic and anti-diabetic activities.

In recent years, an increasing demand for medicinal plants to control diseases for human well being has resulted in the usage of such plants in our society. Current study aims to determine the role of antimicrobial peptides and nanoparticles synthesized by aqueous extract of date fruit palm as antimicrobial, anti-pathogenic, anti-diabetic agents and their effect on hematological parameters. A total of 32 chemical compounds, 21 unique antimicrobial peptides (proteins) and 10 low molecular weight antioxidant peptides were identified in the aqueous extract of Phoenix dactylifera.

Vitamin D cholecalciferol via its hydroxylmetabolites, receptors and metabolizing enzymes modulates male reproductive functions.

Although biologically known for its central role in calcium homeostasis, Vitamin D3 (VD3), owing to its scattered receptors across bodily tissues and the presence of its metabolizing enzymes, has recently garnered scientific attention. This review examined the literature to document the role and specific mechanisms of action of VD3, its receptors, and metabolizing enzymes in male reproduction. Using the keywords Vitamin D3, vitamin D receptors, vitamin D metabolic enzymes, and male reproductive system to search PUBMED and other academic archives, it was observed that VD3, through its interaction with the VDR and with the backing of the activities of its metabolizing enzymes, modulates the male reproductive functions, acting as an antioxidant and anti-inflammatory in reproductive organs to prevent oxidative damages that may result from exposure to environmental toxicants and the increased oxygen utilization by mitochondria owing to high level of unsaturated fatty acids in the testis, thus preventing male infertility.

Melatonin protect against pregabalin-induced gonadotoxicity via anti-oxidative, anti-inflammatory, anti-apoptotic, enzymatic and hormonal regulatory mechanisms in rats.

Background: The therapeutic value of pregabalin in managing various pathological states, such as sleep, anxiety, and bipolar disorders, fibromyalgia, epilepsy, and others, cannot be overstated. Nevertheless, the gonadotoxicity of this drug remains a concern. In contrast, melatonin, an endogenous hormone, is known for its beneficial effects on reproductive tissues following various insults.

A Rare Case of Poorly Differentiated Neuroendocrine Carcinoma of the Descending Colon with Regional Lymph Node Involvement Presenting in a Young Adult Nigerian Male: A Case Report.

Malignant colonic neuroendocrine tumours are rare. Even more uncommon is their occurrence in the left colon. They also infrequently occur in males and young adults.

Defining the genetic profile of prostate cancer.

Several studies indicated that prostate cancer has a hereditary component. In particular, a significant risk of prostate cancer has been linked to a tight familial lineage. However, to provide insight into how prostate cancer is inherited, characterising its genetic profile is essential.

An updated comprehensive review on waste valorization: Informetric analysis, current insights and future perspectives on cereal waste and byproduct utilization for sustainable industrial applications.

Cereal crops have been integral to human sustenance since the Neolithic era which have earned significant attention as staple foods. The year-round cultivation and consumption of cereal-based products have led to the escalating global production of cereals and a rise in industrial processing which results in significant waste generation. These wastes contain high-value nutrients such as carbohydrates, proteins, and lipids.

Views and perspectives toward implementing the Global Spine Care Initiative (GSCI) model of care, and related spine care program by the people in Cross Lake, Northern Manitoba, Canada: a qualitative study using the Theoretical Domain Framework (TDF).

Background: Back pain is very common and a leading cause of disability worldwide. Due to health care system inequalities, Indigenous communities have a disproportionately higher prevalence of injury and acute and chronic diseases compared to the general Canadian population. Indigenous communities, particularly in northern Canada, have limited access to evidence-based spine care.

Evaluation of destruction of bacterial membrane structure associated with anti-quorum sensing and ant-diabetic activity of extract.

Recently, there has been an increasing demand for medicinal plants to control diseases for good health and well-being, as primary health facilities are inadequate in certain populations to cure infections. Since synthetic medicines are toxic to humans and other animals, the present research is thus focused on using traditional medicine for treating various ailments as they are harmless. Based on the above facts, the current study was conducted to assay the antimicrobial, anti-diabetic, anti-cholinesterase, anti-oxidant, anti-quorum sensing, and anti-antibiotic resistance modifying effect of extracts of .

Skoochies and its component substances induced testicular damage and impaired sperm function via increased generation of reactive oxygen species and impairment of the glutathione system in rats.

Objective: To examine the effect of skoochies, an illicit cocktail drink, on testicular and sperm function in male rats.

Design: Twenty-five adult male Wistar rats were assigned randomly into five groups (n = 5) as follows: normal saline; skoochies; Cannabis sativa; codeine; and tramadol. The cocktail (skoochies) used in this study was formulated with the following composition: codeine (5 mg/kg); tramadol (20 mg/kg); and cannabis extract (2 mg/kg).

Bioinformatics proficiency among African students.

Bioinformatics, the interdisciplinary field that combines biology, computer science, and data analysis, plays a pivotal role in advancing our understanding of life sciences. In the African context, where the diversity of biological resources and healthcare challenges is substantial, fostering bioinformatics literacy and proficiency among students is important. This perspective provides an overview of the state of bioinformatics literacy among African students, highlighting the significance, challenges, and potential solutions in addressing this critical educational gap.

Jatonik polyherbal mixture induced rat liver MMPT pore opening in normal Wistar rat: and studies.

Objective: To assess acute toxicity, the and effects of methanol and ethyl acetate extracts (JME and JEE) of Jatonik polyherbal mixture on some mitochondria-related parameters and their effect on the activity of some liver enzymes.

Methods: Acute toxicity of JME and JEE was determined using Lorke's method. and opening of the mitochondrial membrane permeability transition pore (MMPT pore) was spectrophotometrically assayed.

Disruptive consequences of monosodium glutamate on male reproductive function: A review.

Monosodium glutamate (MSG) is one of the most extensively used flavour enhancers worldwide. Although it is widely regarded as a safe food additive with no recommended daily dosage, its over-consumption has been associated with notably pathophysiological events in various tissues and organs of the body. Previous studies have reported of the neuro- cardio- and hepato- toxic effects of its excessive exposure.

Role of chromium reductases, antioxidants, and biosorption against oxidative damage of metals by Bacillus cereus.

Current research was performed to look for the performance of Bacillus cereus PY3 for metal detoxification. Strain PY3 was recognized as B. cereus using 16 S rRNA.

Acetate attenuates cyclophosphamide-induced cardiac injury via inhibition of NF-kB signaling and suppression of caspase 3-dependent apoptosis in Wistar rats.

Aim: The goal of the current study was to examine the potential therapeutic effects of sodium acetate on cardiac toxicities caused by cyclophosphamide in Wistar rats. The possible involvement of NF-kB/caspase 3 signaling was also explored.

Main Methods: Thirty-two male Wistar rats were divided into four groups at random.

Remediation of hydrocarbons and metals by hydrocarbon utilizing Pseudomonas taiwanensis YSA-17 isolated from soil contaminated with petroleum.

Careless handling of petroleum in petrochemical industries releases toxic hydrocarbons and metals to soil and water. The aim of the present study was to isolate hydrocarbon-utilizing and metal-tolerant bacteria. Hydrocarbon-utilizing bacteria from petroleum-contaminated soils were isolated on the Bushnell Hass medium.

Mechanism associated with changes in male reproductive functions during ageing process.

Ageing is a natural process with physiological changes in different body parts and has been associated with decreased reproductive capacity. Factors such as imbalance in the antioxidant defence system, vascular diseases, diabetes mellitus, accessory reproductive glands infection, obesity as well as buildup of toxic substances play a role in age-related male reproductive malfunction. Age is inversely proportional to volume of semen, sperm count, sperm progressive motility, sperm viability, normal sperm morphology.

Reinstating apoptosis using putative Bcl-xL natural product inhibitors: Molecular docking and ADMETox profiling investigations.

Objectives: While a fine balance in the pro-apoptotic and anti-apoptotic family members of the B-cell lymphoma-2 (Bcl-2) protein family represents a normal signaling profile, a tilt in balance towards anti-apoptotic family members has fortified different forms of cancers with survival advantage and resistance against treatment. Induction of apoptosis is a key therapeutic approach in cancer drug discovery, and the inhibition of the anti-apoptotic B cell lymphoma extra-large (Bcl-xL) is a long-standing clinical target for cancer therapy. In this study, we combined computer-aided approaches to report putative binders for this target.