Dietary vitamin D and gastric cancer risk within the stomach cancer pooling (stop) project.

Purpose: The evidence regarding the role of vitamin D on gastric cancer (GC) is controversial. Within the Stomach cancer Pooling (StoP) Project, a global consortium of epidemiological studies on GC, we aimed to evaluate the relationship between dietary vitamin D and GC risk.

Methods: Five case-control studies were included in the analysis, accounting for 1875 cases and 5899 controls.

Building Lay Society Knowledge and Education for Health Technology Assessment and Policy Engagement: Case of CFTR Modulator Access in Brazil.

The health technology assessment (HTA) is a multidisciplinary process utilized to determine the clinical, economic, social, and ethical value of new health technologies before they are incorporated into healthcare systems. In the case of rare diseases, such as Cystic Fibrosis (CF), challenges arise due to limited evidence and high treatment costs. Indeed, although CF transmembrane conductance regulator (CFTR) modulators are breakthrough therapies for CF, their incorporation into public health systems has been complex with considerable challenges, especially in low- and middle-income countries.

base-excision restriction enzyme in stomach carcinogenesis.

Many recent lines of evidence from the human microbiome and other fields indicate bacterial involvement in various types of cancer. has been recognized as the major cause of stomach cancer (gastric cancer), but the mechanism by which it destabilizes the human genome to cause cancer remains unclear. Our recent studies have identified a unique family of toxic restriction enzymes that excise a base (: adenine) from their recognition sequence (5'-GTC).

Novel Copper Chelators Enhance Spatial Memory and Biochemical Outcomes in Alzheimer's Disease Model.

This study explores the potential of novel molecules that can act as copper chelators to treat Alzheimer's disease. Eight imines and one quinoline-based compound were synthesized, characterized, and evaluated as compounds that can act to reverse neurodegeneration in vivo. Their ability to extract copper from the Cu-β-amyloid complex, a key factor in Alzheimer's pathology, was assessed, achieving a remarkable in vitro activity for , , and .

Effect of bucket hydrotherapy on clinical parameters in infants with bronchopulmonary dysplasia: A pilot randomized clinical trial.

Introduction: It is unknown whether bucket hydrotherapy is beneficial to premature newborns with bronchopulmonary dysplasia (BPD).

Objective: To evaluate the effects of bucket hydrotherapy on physiological and behavioural parameters and the oxygen need in preterm infants with BPD during hospitalization.

Methods: Twenty infants with BPD were randomized into a control (conventional physiotherapy - PG) or an intervention group (conventional physiotherapy plus bucket hydrotherapy - BHG).