Wellbeing across the American Nations: First Settler Effects influence traditional and existential wellness.

This study investigates the "First Settler Wellness Effect," exploring how cultural geography impacts traditional wellness (physical health, social relationships, and financial stability) and existential wellness (purpose, meaning, and community identity) across the United States. Using data from the Gallup-Healthways Well-Being Index, which includes responses from over 325,000 individuals across 110 Metropolitan Statistical Areas (MSAs) from 2009 to 2016, we analyze wellness outcomes through the lens of the American Nations Model. This model categorizes the United States into distinct cultural regions shaped by early settlement patterns, emphasizing the enduring influence of regional norms and ideologies.

Architecture of systems affecting disease trajectories in a conflict zone: A community-centered systems inquiry in North Gaza.

Humanitarian crises, particularly in conflict zones, create cascading disruptions that impact every aspect of daily life, including health and disease outcomes. While international humanitarian frameworks categorize these crises into discrete operational clusters, affected populations experience them as interwoven, systemic failures. This study examines how conflict-induced disruptions transform a preventable and typically self-limiting disease-Hepatitis A-into a fatal outcome.

A life course perspective on predictors of midlife socioeconomic status.

Background: Previous studies have found paternal occupation, childhood intelligence, and educational attainment to be important predictors of socioeconomic status (SES) later in life. However, these factors only explain part of the variance in SES and thus, it is important to identify other predictors of SES and trajectories of influence from early childhood to adulthood.

Objectives: To analyze predictors of SES attainment during the life course from early childhood to midlife with special emphasis on identifying direct and indirect effects on midlife SES of early childhood, late childhood and young adult characteristics.

Serotonergic receptor binding in the brainstem in the Sudden Infant Death Syndrome in a high-risk population.

The Sudden Infant Death Syndrome (SIDS) is a major global health problem, with increased risk among socioeconomically disadvantaged populations. We propose SIDS, or a subset, is due to a defect in the brainstem serotonin system mediating cardiorespiratory integration and arousal. This defect impinges on homeostasis during a critical developmental period in infancy, especially in populations experiencing maternal and infantile stress, resulting in sleep-related sudden death.

Gaps in care across the cancer screening continuum for cervical, colorectal and lung cancer.

Background: While screening for cervical, colorectal, and lung cancers reduce cancer-specific mortality, the full benefits of screening are only realized when coupled with timely care across the subsequent "screening continuum" steps, including surveillance (results warranting frequent monitoring), diagnostic evaluation (results that require additional testing), and treatment (detected cancers). Our goal was to describe the proportion of individuals receiving timely cervical, colorectal, and lung cancer care at each step in the screening continuum.

Methods: This retrospective cohort study used data from the 10 health care settings that participate in the Population-based Research to Optimize the Screening Process (PROSPR II) consortium and included individuals who were eligible for a step along the cancer screening continuum in 2018.

Racial/ethnic differences in the association of lifestyle factors with biological aging in NHANES, 1999-2018.

Racial and ethnic disparities in healthy aging represent an emerging public health crisis that will only grow worse as our population grows older. Healthy lifestyle behaviors are proposed as a key strategy to promote healthy aging. However, the potential of lifestyle interventions to address aging health disparities is uncertain.

Investigating the role of family members in postnatal care: Evidence from mother-caregiver dyads in India.

Objectives: In this study, we examine the dynamics of birthing women relative to other family members in making caregiving decisions about postpartum maternal and infant care in four states in India. Specifically, we investigate the involvement of the father, maternal grandmother, and paternal grandmother of the newborn in household health decision-making.

Methods: We analyze data from 551 dyads of women with infants under six months and the family caregiver identified as providing the primary support in the postpartum period.

Is Training Alone Enough? A Comparison of Serious Illness Communication Training With and Without Implementation Strategies.

Communication skills training alone has shown limited impact on improving the frequency and quality of serious illness conversations (SICs). Implementing structured support strategies may enhance both adoption and sustained use in clinical practice. Retrospective review of the impact of Serious Illness Care Program (SICP) training and implementation in outpatient and inpatient settings at a single academic center.

Visceral Adipose Tissue Cut-Points for Increased Metabolic Risk in Chinese Adults using Low Dose Computed Tomography: a Nationwide Multi-Centre Study.

Introduction: Visceral adipose tissue (VAT) is a significant driver for metabolic disease risk. Low dose computed tomography (LDCT) imaging obtained for other clinical indications is useful for the opportunistic screening of osteoporosis and demonstrates additional potential for the screening of metabolic risk through the measurement of visceral adipose tissue. In this study, we explored LDCT-derived VAT and calculated VAT thresholds indicative of elevated metabolic risk in a population cohort of Chinese men and women.

Top Ten Tips Palliative Care Clinicians Should Know About Intentionally Interprofessional Collaboration.

Although high-quality and holistic specialty palliative care is delivered by an interprofessional team, little guidance is available to optimize approaches to and sustainment of such teamwork. This article supports individuals to practice at the top of their education, clinical training, and scope of practice while maximizing the functionality of the palliative care team as a whole. We intentionally use the term rather than to clarify that we are focused on collaboration of team members who represent multiple professions or occupations that require specialized training and meet ethical standards (e.

Parity, Age at Childbirth, and Later-Life Health-Related Quality of Life in Postmenopausal Women.

We aimed to examine the long-term effects of parity, age at first childbirth, and age at last childbirth on later-life health-related quality of life (HRQoL) in postmenopausal women. The Women's Health Initiative data included 15,416 postmenopausal women with repeated measures in HRQoL. We used propensity score matching to create matched samples, where each exposure group was matched with a reference group based on their propensity scores.

Results of Photopatch Testing in Israel: A Retrospective Cohort Study.

There are limited data regarding photopatch testing (PPT) in Israel. To investigate the prevalence of positive reactions and concurrent diagnosis of patients that underwent PPT in a single center in Israel. Retrospective cohort study that included all patients that were suspected of having contact dermatitis and underwent patch testing with the European baseline series (EBS) and additionally were selectively PPT with the Scandinavian/European baseline photopatch series in a tertiary medical center in Israel (2009-2023).

The "Secret of Seven Stones": Short-Term Efficacy of an Online Intergenerational Sexual Health Education Game for Early Adolescents and Their Parents.

Intergenerational games offer a potential channel to impact parent-youth sexual health communication. The "Secret of Seven Stones" (SSS) is an 18-level online adventure game and parent website designed to engage parents and youth (11-14 years) in conversations about healthy dating relationships and sexual behavior and to provide sexual health skills training to youth. Study hypotheses were that SSS exposure would increase sexual health parent-child communication, increase youth intentions to delay sexual debut, and reduce youth exposure to situations that promote sexual activity.

AmpliconTyper - a tool for analysing ONT multiplex PCR data from environmental and other complex samples.

Amplicon sequencing is a popular method for understanding the diversity of bacterial communities in samples containing multiple organisms as exemplified by 16S rRNA sequencing. Another application of amplicon sequencing includes multiplexing both primer sets and samples, allowing sequencing of multiple targets in multiple samples in the same sequencing run. Multiple tools exist to process the amplicon sequencing data produced via the short-read Illumina platform, but there are fewer options for long-read Oxford Nanopore Technologies (ONT) sequencing, or for processing data from environmental surveillance or other sources with many different organisms.

Sex does not Influence Neuronal Autophagosome Biogenesis throughout Aging in Mice.

Autophagy is critical for the homeostasis and function of neurons, as misregulation of autophagy has been implicated in age-related neurodegenerative diseases and neuron-specific knockdown of early autophagy genes results in early neurodegeneration in mice. We previously found that autophagosome formation decreases with age in murine neurons. Sex differences have been intensely studied in neurodegenerative diseases, but whether sex differences influence autophagy at the neuronal level have not been investigated.

Epidemiology of Infections in Canada: 2000-2022.

is a human-specific protozoan parasite that causes gastrointestinal illness, primarily through the ingestion of contaminated water or fresh produce. This study provides an epidemiological overview of cyclosporiasis in Canada from 2000 to 2022 using data from the Canadian Notifiable Disease Surveillance System, FoodNet Canada, and outbreak investigations. A total of 5337 cases were reported during this period, with the incidence increasing from 0.

Effects of Therapies on Proteinuria and Estimated Glomerular Filtration Rate in IgA Nephropathy: Meta-Analysis of Randomized Trials.

Background: Substantial advances have been made in therapeutics for IgA nephropathy. We conducted a systematic review and meta-analysis to evaluate the comparative efficacy and safety of existing and novel IgA nephropathy therapies.

Methods: We searched MEDLINE and Embase databases from inception to May 21, 2025 for Phase 2b and 3 multi-center, randomized, placebo-controlled trials enrolling patients with IgA nephropathy that reported treatment effects on proteinuria and/or estimated glomerular filtration rate (eGFR) slope.

The effect of caffeine use in the relationship between gaming and sleep in adolescents: A mediation analysis.

Background And Aims: Caffeine is the most commonly used substance during gaming sessions. Despite health guidelines to avoid caffeine before adulthood, many adolescents use caffeine to compensate for lost sleep or prolong wakefulness to enhance gaming performance. The relationship between gaming and sleep is well-established, but the role of caffeine has been under-explored.

Impact of digital addiction on youth health: A systematic review and meta-analysis.

Background And Aims: Digital addiction among youth, characterized by excessive and compulsive use of digital devices such as smartphones, computers, and social media platforms, has become a global concern. The present study aimed to investigate the association between digital addiction subtypes in youth and various health outcomes using "digital addiction" as an umbrella term.

Methods: We comprehensively reviewed articles reporting health outcomes related to digital addiction in youth from the Chinese National Knowledge Infrastructure (CNKI), Wanfang, PubMed, and Web of Science databases using a targeted search strategy and assessed them using predefined inclusion and exclusion criteria.

Factors associated with persistent high healthcare service utilisers in Singapore: A population health analysis.

Introduction: Albeit comprising a small portion of the hospital population, persistent high utilisers (PHUs) contribute disproportionately to healthcare expenditures. Amid rising healthcare costs and an ageing population, this study examines factors associated with PHUs among residents in eastern Singapore.

Method: This is a retrospective study of eligible patients at Changi General Hospital in Singapore between 1 January 2020 and 31 December 2022.

Automatic brain segmentation in cognitive impairment: Validation of AI-based AQUA software in the Southeast Asian BIOCIS cohort.

Introduction: Interpretation and analysis of magnetic resonance imaging (MRI) scans in clinical settings comprise time-consuming visual ratings and complex neuroimage processing that require trained professionals. To combat these challenges, artificial intelligence (AI) techniques can aid clinicians in interpreting brain MRI for accurate diagnosis of neurodegenerative diseases but they require extensive validation. Thus, the aim of this study was to validate the use of AI-based AQUA (Neurophet Inc.

Evaluating the impact of relative dose intensity on efficacy of trastuzumab deruxtecan for metastatic breast cancer in the real-world clinical setting.

Introduction: Trastuzumab deruxtecan (T-DXd) has revolutionised treatment for metastatic breast cancer (MBC). While effective, its high cost and toxicities, such as fatigue and nausea, pose challenges.

Method: Medical records from the Joint Breast Cancer Registry in Singapore were used to study MBC patients treated with T-DXd (February 2021-June 2024).

[Modern view on the mechanism of traffic injury in collision of moving vehicle and pedestrian].

The article considers the main phases of traffic injury (TI) described by A.A. Solokhin in 1968 and their modern application in forensic medical and automotive examination.

Diverse Attitudes and Experiences With Technology Use During the COVID-19 Pandemic Among Asian American and Pacific Islander Adults (the COMPASS Study): Survey Study.

Background: The COVID-19 pandemic forced the world to quarantine to slow the rate of transmission, causing communities to transition into virtual spaces. Asian American and Pacific Islander communities faced the additional challenge of discrimination that stemmed from racist and xenophobic rhetoric in the media. Limited data exist on technology use among Asian American and Pacific Islander adults during the height of the COVID-19 shelter-in-place period and its effect on their physical and mental health.

Development of an Instrument to Measure Resilience to Misinformation on Social Media: Measurement Properties and Validation.

Background: The spread of misinformation on social media poses significant risks to public health and individual decision-making. Despite growing recognition of these threats, instruments that assess resilience to misinformation on social media, particularly among families who are central to making decisions on behalf of children, remain scarce.

Objective: This study aimed to develop and evaluate the psychometric properties of a novel instrument that measures resilience to misinformation in the context of social media among parents of school-age children.