Scientific mapping for detoxification of chemical warfare agents using porous organic polymers with internal molecular free volume.

Chemical warfare agents (CWAs) have been a consistent a global concern with regard to both defence and civilian safety. In order to safeguard people from these harmful chemicals, numerous research teams have collaborated with defence organizations to find an advanced technological solution in terms of effectiveness and strength. In this context, porous organic polymers (POPs) have been thoroughly investigated as an ideal option for catalytically detoxifying CWAs by initially capturing them and subsequently transforming them into harmless chemicals.

One pot access to 2-iodo-2-deoxy nucleosides directly from glycals and unprotected nucleobases and their biological evaluation on the Japanese Encephalitis Virus.

An expedient one-pot stereo- and regioselective synthesis of 2-iodo-nucleosides from protected glycals and nucleobases using easily available iodine and hexamethyldisilane as halogenating, and silylating agents respectively has been developed. Most of the products synthesized characterized as diastereomerically pure β-1,2-trans-diequitorial nucleosides hitherto not reported. The studies unveil the cogent antiviral activity of these newly synthesized nucleoside derivatives against the Japanese Encephalitis Virus (flavivirus) in the Vero cell line.

Cu(i)-catalyzed enantioselective and stereospecific borylative annulation of cyclic 1,3-dione-tethered 1,3-enynes.

A copper(i)-catalyzed, highly enantioselective, and diastereoselective borylative cyclization of prochiral cyclic 1,3-dione-tethered 1,3-enynes is reported. This stereospecific transformation exhibits a broad substrate scope, enabling access to bicyclic organoboron products containing four contiguous stereocenters with excellent enantioselectivity. Notably, the reaction rate is significantly influenced by the substrate's stereochemistry, with the ()-isomer undergoing borylative cyclization much faster than the ()-isomer due to reduced steric interactions during C-C bond formation.

Emergence of In Vitro Glioblastoma Survival via Adaptive Quasi-Quiescence by Emulsion Copolymer Matrix.

In nature, many organisms enhance their chances of survival by adapting their structures to changing environments. Such adaptation is demonstrated herein, in glioblastoma, via spheroid assembling on the surface of engineered emulsion matrix. Glioblastoma multiforme, the most challenging primary brain malignancy, is characterized by its aggressive nature and poor patient outcomes.

Multifunctional ZnO Nanoparticles Synthesized Using Extract: Characterization, Photocatalytic Activity, Antimicrobial Assessment, and In Silico Modeling.

This study investigates the green synthesis of zinc oxide nanoparticles (ZnO NPs) using the aqueous extract of the aquatic plant (greater duckweed) and evaluates their multifunctional properties. The ZnO NPs were synthesized via a sustainable method and characterized using UV-visible spectroscopy, TEM, FESEM, EDX, FTIR, and XRD analyses. UV-visible spectroscopy confirmed the formation of ZnO NPs with a characteristic absorption peak at ∼349 nm.

Deconstructive [4 + 3] Annulation of Isatin-Derived α-Keto Amides with CF-Allyl-Pd Species.

The catalytic one-pot cascade reaction is a powerful strategy for constructing complex molecules with high regioselectivity. Herein, we present a cascade allylative double intramolecular cyclization (ADIC) for synthesizing benzopyrroloazepines via a deconstructive [4 + 3] annulation of isatin-derived α-keto amides with CF-allyl-Pd species. This transformation efficiently integrates isatin ring opening, Tsuji-Trost allylation, and double intramolecular cyclizations involving three C-F bond disconnections.

Healing power of (Sw.) Raf.: a comprehensive review of its phytochemicals, pharmacology aspects, and potential health benefits.

(Sw.) Raf. (Mesquite), formerly known as (SW.

2,4,6-trichloro-1,3,5-triazine catalyzed Fischer type dehydrative glycosylation for the synthesis of 2-deoxy glycosides.

The stereoselective synthesis of 2-deoxy O-glycosides is challenging due to the absence of a C2-directing group. Herein, we report the first use of 2,4,6-trichloro-1,3,5-triazine (TCT) as an organocatalyst for the direct dehydrative glycosylation of sugar hemiacetals with a wide range of alcohol acceptors. This metal-free protocol proceeds under mild conditions to afford 2-deoxy glycosides with high α-selectivity, broad substrate scope, and good functional group tolerance.

Stereoselective total synthesis of cytotoxic cyclodepsipeptide menominin B: call for revision of the proposed structure.

The stereoselective total synthesis of the proposed structure of menominin B is described. A convergent approach involving multi-ester coupling and peptide coupling, along with key reactions such as Evans aldol and Maruoka allylation reactions for generating new chiral centers, and finally the ring-closing metathesis (RCM) for obtaining the macrocyclic framework, is demonstrated. The structure of the synthetic menominin B was established through extensive COSY, and HMBC analysis and finally confirmed by X-ray diffraction data.

Pd-catalyzed electrophilic cyclization/C-H annulation cascade of 1,8-diyne oxime ethers to access fused oxepines.

Harnessing the metal-catalyzed cascade cyclizations constitutes a challenging task but offers an outstanding tool to access polycyclic scaffolds. We present herein a Pd(II)-catalyzed cascade cyclization of 1,8-diyne oxime ethers a consecutive intramolecular oxy-palladation/carbopalladation/C-H annulation for the construction of oxepine-fused trinuclear polycyclic scaffolds. Some control and kinetic experiments were carried out to understand the mechanism, and a few product elaborations were achieved to further showcase the potential of the reaction.

One-pot multi-component synthesis and biological evaluation of spirooxindole carbamate derivatives of major flavonoids isolated from oroxylum indicum: Identification of potent anti-proliferative leads active against hepatocellular carcinoma.

A series of 30 novel spirooxindole carbamate derivatives of flavonoids (chrysin, oroxylin A and baicailein) were synthesized in a one-pot three-component reaction via a sequence of Knoevenagel condensation, cyclization reactions in a highly efficient and selective manner. The structures of all the derivatives (6a-6 l, 7a-7 l and 8a-8f) were characterized by interpretation of NMR (H NMR, C NMR) and mass spectral data. The structures of the compounds 6d and 7f were further confirmed by single-crystal X-ray diffraction for the first time.

Bisdemethoxycurcumin mitigates Alzheimer disease pathology through autophagy-mediated reduction of senescence and amyloid beta.

AD pathology is accompanied by increased senescence and reduced levels of autophagy in the brain. We investigated whether pharmacologically inducing autophagy could alter the senescent phenotype and help ameliorate AD pathology. We discovered that Bisdemethoxycurcumin (BDMC), a natural compound found in , stimulates autophagy in primary astrocytes.

One-pot solvothermal synthesis of ZnCoS/carbon nanosphere composites: tuning carbon content for high-performance supercapacitor electrodes.

The impact of carbon loading in binary transition metal sulphide-based nanocomposites for designing high-performance supercapacitor electrodes requires a comprehensive investigation. In this work, a series of nanostructured materials-including pristine ZnCoS, carbonaceous nanospheres (CNS), and a set of dextrose-derived ZnCoS/CNS nanocomposites (labelled as ZnCoS/CNS (D), where '' denotes the mole ratio of dextrose (D) to the Zn precursor and takes values of 1, 2, 5, and 10)-were synthesized a facile, one-pot, solvothermal route. Notably, the ZnCoS/CNS (D2) nanocomposite exhibited a heterogeneous and porous nano/microsphere morphology with efficient integration of ZnCoS and CNS.

Trimodal Ni(II) Complex of Natural Coumarin: Enhanced Lung Cancer Therapy through Chemo, Photodynamic, and Photothermal Approaches under Red and NIR Light.

We report four square planar Ni(II) complexes [Ni(B)(L)] (-), where B is 1,10-phenanthroline (, ) or dipyrido[3,2-a:2',3'-c]phenazine (, ) and L is the dianionic form of catechol (, ) or esculetin (, ). These complexes absorb in the red and NIR region (600-850 nm) and remain stable under thermal, photo, and dark conditions. showed strong phototoxicity under combined 660 and 808 nm light via singlet oxygen generation and local hyperthermia, with IC = 0.

Diastereoselective and Regioselective Tunable Cascade Annulation of Prochiral Enone-Tethered Cyclohexadienones.

We report a highly diastereoselective and regioselective base- and solvent-controlled cascade annulation of enone-tethered cyclohexadienones with nitroalkanes, affording diverse polycyclic scaffolds with up to six contiguous stereocenters. The use of the less nucleophilic base EtN favors the formation of bicyclic products, while DBU promotes the generation of tricyclic frameworks or highly strained fused tetracyclic cyclopropanes, depending upon the solvent. Mechanistic investigations indicate a reaction pathway involving sequential Michael additions followed by nucleophilic substitution of the nitro group.

GC/MS Investigation of the Reaction Products of Nitrogen Mustards and N,N-Dialkylaminoethyl-2-Chlorides With Phenol.

The Chemical Weapons Convention (CWC)-scheduled chemicals that contain chlorine atom (e.g., mustards, aminoethyl-2-chlorides, and phosphorylchlorides) are highly reactive in environmental matrices, especially when they are in contact with phenols, for example, in the decontamination process.

Organophotoredox-catalyzed deconstructive alkylation/Truce-Smiles rearrangement cascade involving spiro-dihydroquinazolinones and activated alkenes.

An organophotoredox-catalyzed cascade reaction involving C-C σ-bond cleavage, C-C bond formation, and a subsequent Truce-Smiles rearrangement has been developed using spiro-dihydroquinazolinones and activated alkenes. This aromaticity-driven deconstructive functionalization strategy efficiently yields valuable quinazolinone-containing long-chain amides bearing an α-all-carbon quaternary center. Mild redox-neutral conditions, good functional group compatibility and high atom economy are the noteworthy features of this methodology.

Interfacial Engineering of 2D-2D CdInS/TiC Heterojunctions for Enhanced Photocatalytic Hydrogen Generation.

Utilization of solar energy through wireless water-splitting technology offers a promising pathway toward a sustainable and environmentally conscious future. The rational design of 2D-2D heterojunctions leverages synergistic effects to optimize charge carrier dynamics, thereby boosting photocatalytic activity. In this study, well-engineered heterojunction TiC/CdInS (TCIS) nanocomposites are synthesized via an in situ hydrothermal method and employed in photocatalytic hydrogen evolution (PHE).

Enzymatic Pathway for Kupyaphore Degradation in : Mechanism of Metal Homeostasis and Turnover.

Metallophores are essential for metal homeostasis, regulating availability, and mediating host-pathogen interactions. Kupyaphores are specialized metallophores produced by () that primarily chelate zinc to support bacterial survival. Elevated kupyaphore levels early in infection highlight their importance, while their rapid decline, despite increasing bacterial loads, indicates tightly regulated mechanisms of production, consumption, and degradation.

Direct Assembly of Functionalized 3-Hydroxypyridine -Oxides via Cascade Nitration/Hydroxylative -Annulation Reactions.

Herein, we introduce an innovative method for the direct access to multisubstituted pyridine -oxides (PyNOs) from an acyclic precursor, MBH-acetates of propiolaldehydes. The reaction proceeds through nitration, followed by hydroxylative -annulation in one pot involving the formation of two C-N and one C-O bonds. The method provides a diverse platform to access the pyridine -oxides either with or without iodination at the C-6 position.

Heavy Atom Integration in 2-Hydroxymethylquinoline: A Rational Strategy for Enhanced Two-Photon Absorption-Mediated Tumor and Nuclear-Targeted Drug Delivery in Triple-Negative Breast Cancer.

Two-photon absorption (TPA) technology has emerged as a promising approach for precise drug delivery due to its deep tissue penetration and high spatial selectivity. This study introduces a rational design approach to enhance TPA-mediated drug delivery by incorporating an increasing number of heavy bromine atoms into the hydroxymethylquinoline (HMQ) framework. The resulting molecules exhibit significantly improved TPA properties (TPA cross section of up to 130 GM), enabling efficient tumor and nuclear targeting in triple-negative breast cancer (TNBC) models.

Metabolic Reprogramming of Urothelial Carcinoma-A Theragnostic Target for Betulinic Acid.

A pivotal role of metabolic reprogramming in urothelial carcinoma is hallmarked by the dependence of two-fold faster proliferation of urothelial carcinoma cell line T24 than benign cell line TRT-HU1 on five-fold higher glucose (basal) 16 mM vs. 3 mM in McCoy's 5A media and Keratinocyte Serum Free media, respectively. Here, we report that an additional 10% increase to 17.

N-imidazopyridine derivatives of noscapine as potent tubulin-binding anticancer agents: chemical synthesis and cellular evaluation.

In this study we present a novel class of N-imidazopyridine (impy) derivatives (12-15) of noscapine by tethering the imidazo[1,2-a]pyridine core to the N-atom of the isoquinoline ring of the lead molecule noscapine. These derivatives were found to have better docking scores (- 6.213 to - 7.

Recent advances in transition metal-catalyzed alkyne annulations: applications in organic synthesis.

Transition metal-catalyzed alkyne annulation has emerged as a powerful strategy for constructing diverse cyclic frameworks with high efficiency and selectivity. This methodology exploits the unique reactivity of transition metals to activate alkynes, enabling the formation of carbocycles and heterocycles. Recent advances-including cooperative catalysis, dual-catalyst systems, and electrochemical transformations-have significantly broadened the scope of achievable structures.

NARI-29: A Novel Epalrestat Derivative Attenuates Pulmonary Fibrosis by Modulating the TGF-β/Smad Signaling.

Pulmonary fibrosis is a chronic and debilitating lung disease marked by excessive collagen and extracellular matrix accumulation, leading to lung scarring and impaired lung function. Though pirfenidone and nintedanib are approved drugs, their efficacy is suboptimal. The current study aims to examine the antifibrotic activity of a novel epalrestat (aldose reductase) analog (NARI-29) using and rat models.