The Temporal and Spatial Distribution Patterns of Necrotic and Apoptotic Cells in and Around the Spinal Cord Injury Site.

: Acute spinal cord trauma management necessitates understanding the primary and secondary injury mechanisms at different timepoints. : To characterize the cell death process by examining the temporal and spatial distributions of necrosis and apoptosis in an experimental spinal cord injury model. : Wistar male rats were divided into trauma (n = 30) and sham (n = 6) groups, and a 50 g/cm weight drop contusion design was used.

Retrospective study comparing 30-day surgical outcomes of pancreaticoduodenectomy for pancreatic head adenocarcinoma in patients with and without malnutrition defined by the GLIM criteria.

This single-center study conducted in Turkey aims to assess the impact of preoperative nutritional status based on global leadership initiative on malnutrition criteria on 30-day postoperative surgical outcomes in patients undergoing pancreaticoduodenectomy (PD) for pancreatic head adenocarcinoma. A retrospective analysis was conducted on patients who underwent PD. Patients were classified into 2 groups based on preoperative nutritional assessments of global leadership initiative on malnutrition criteria: malnourished (n = 23; 46%) and nonmalnourished (n = 27; 54%).

Evaluation of the Peripheral Vestibular System in Individuals with Vision Loss.

BACKGROUND: The aim of this study was to determine whether there are differences in the balance system between individuals with vision loss and a healthy control group using the video head impulse test (vHIT), cervical vestibular evoked myogenic potentials (cVEMP) and ocular vestibular evoked myogenic potentials (oVEMP) tests. METHODS: The study included 23 individuals diagnosed with bilateral low vision, 20 individuals diagnosed with bilateral blindness, and 50 healthy control subjects. vHIT, cVEMP, and oVEMP tests were applied to all participants to evaluate the vestibular system.

Pre-transplant predictors of 3-Month survival following liver transplantation for acute liver failure in adult and pediatric patients in Türkiye.

This multicenter retrospective study analyzed 336 patients (236 adults, 100 children) who underwent liver transplantation (LT) for acute liver failure (ALF) between 2002 and 2019 across 14 centers in Türkiye. The aim was to evaluate pretransplant factors influencing short-term posttransplant survival. Median MELD and PELD scores were 31 and 30, respectively.

Tuberculosis in Turkiye: Epidemiological insights and recommendations for progress.

Background: Tuberculosis (TB) remains a significant global public health challenge. We provide an overview of the current TB epidemiology in Turkey, highlighting key findings related to TB incidence, diagnostic challenges, and treatment outcomes.

Results: A gradual decline in TB incidence in Turkiye has been observed over recent years.

Prognostic factors in ovarian cancer patients with brain metastases: A retrospective analysis.

Objective: Brain metastases (BM) from epithelial ovarian cancer (EOC) are rare but clinically significant due to their poor prognosis. This study aimed to investigate prognostic factors influencing survival in EOC patients who developed BM and to evaluate treatment-related outcomes.

Methods: A retrospective review was conducted on 1123 patients with EOC treated between 2008 and 2021.

Effect of shockwave lithotripsy before percutaneous nephrolithotomy on the risk of renal arteriovenous fistula.

Introduction: This study aimed to assess the impact of shockwave lithotripsy (SWL) on the incidence of renal arteriovenous fistula (AVF) following percutaneous nephrolithotomy (PCNL).

Methods: We retrospectively analyzed data from patients who underwent PCNL and/or SWL for kidney stones, as well as angioembolization for renal AVF, between January 2000 and December 2024. Patients with inadequate followup or insufficient medical records were excluded.

Portal vein thrombosis after laparoscopic appendectomy for acute appendicitis: A case report.

Rationale: Portal vein thrombosis (PVT) has a complex pathophysiologic pathway and may cause life-threatening clinical complications. Malignancies, hepatic cirrhosis, auto-immune disorders, previous splenectomy, and other causes of thrombocytosis (over 1,000,000/mL) are the most common causes of PVT. On the other hand, hematologic disorders and infectious processes in the abdominal cavity may cause PVT uncommonly.

The digital dialogue on premature ejaculation: evaluating the efficacy of artificial intelligence-driven responses.

Purpose: This study investigated the quality and comprehensibility of responses generated by three prominent artificial intelligence-powered chatbots (ChatGPT, Gemini, and Llama) when queried about premature ejaculation (PME).

Methods: A set of 25 frequently asked questions (FAQs) were identified on the basis of Google Trends and Semrush platforms. Each chatbot was prompted with these questions and their responses were analyzed via a comprehensive set of metrics.

Comparative Outcomes of Surgical Techniques for Pilonidal Sinus: A Turkish Retrospective Study.

BACKGROUND Pilonidal sinus is a chronic or acute infectious disease in the intergluteal cleft. Various surgical treatments exist, but optimal management remains debated. This study compares outcomes of primary midline closure (PMC), Karydakis flap (KF), Limberg flap (LF), and laser pilonidotomy (LP) in adult patients with pilonidal sinus disease.

Effect of Pycnogenol® on Noise-Induced Hearing Loss in Rats.

Background: This study aims to elucidate the potential protective effects of Pycnogenol® against noise-induced hearing (NIHL) loss in a rat model. Methods: This study employed a randomized controlled design to investigate the potential protective effects of Pycnogenol® against NIHL in a rat model. Twenty-five male Wistar albino rats were randomly assigned to 5 groups (n=5 per group): a control group receiving saline administration, a noise exposure group, a noise+saline receiving group, only Pycnogenol® receiving group, and finally, a Pycnogenol® treatment group receiving daily oral administration of Pycnogenol® at 40 mg/kg/day via gavage for 7 days following noise exposure.

A Novel Surgical Technique for Transsphincteric Anal Fistulas: A Comparison Between the Modified Submucosal Ligation of Fistula Tract (MSLOFT) and the Hybrid Seton Techiniques - A Propensity Score Matching Analysis.

BackgroundThis study aimed to compare the outcomes of a modified submucosal ligation of the fistula tract (MSLOFT) technique with the hybrid seton technique for treating transsphincteric anal fistulas.Material and MethodsA retrospective analysis was conducted with ethical approval from Baskent University. Patients over 18 years of age with a diagnosis of transsphincteric fistula and complete data were included in the study.

Long-Term Outcomes of Allogeneic Stem Cell Transplantation for Relapsed/Refractory Hodgkin and Non-Hodgkin Lymphoma: Multi-center Experience from Turkey.

This multicenter retrospective study evaluated the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) on survival and safety in patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). A total of 110 patients with R/R HL or NHL who underwent allo-HSCT between July 2007 and October 2022 at 7 adult stem cell transplant centers were evaluated. Progression-free survival (PFS), graft versus host disease-free survival (GRFS), and overall survival (OS) were the primary endpoints, and NRM was the secondary endpoint.

THE EVALUATION OF SHORT AND LONG-TERM QUALITY OF LIFE IN PATIENTS UNDERGOING THYROIDECTOMY DUE TO BENIGN OR MALIGNANT DISEASES.

Context: In patients undergoing thyroidectomy for malignant disease, lower quality of life scores were observed in the early postoperative period compared to those undergoing thyroidectomy for benign causes.

Objective: Thyroid gland diseases are commonly encountered in society. This study presents health-related quality of life differences in thyroidectomies performed for benign and malignant diseases and the factors affecting this.

Sex differences in clinical and polysomnographic features of obstructive sleep apnea: The Turkish sleep apnea database (TURKAPNE) cohort.

Background: Previous reports from relatively small clinical cohorts have suggested that the clinical presentation of obstructive sleep apnea (OSA) differs between men and women.

Objective: We aimed to explore sex differences in clinical and polysomnographic features of OSA in a large nationwide registry.

Methods: Participants from the ongoing Turkish Sleep Apnea Database (TURKAPNE) Study from 34 centers were included in the current analysis.

Associations Between Echocardiographic Right Heart Measurements With Short-Term Prognosis in Heart Failure: A Prospective Study.

Background: Echocardiographic right ventricular (RV) dysfunction is a strong risk determinant for prognosis in patients with heart failure (HF). Although parameters of RV systolic function are widely used to define RV dysfunction, there is scarce data to suggest these parameters are best suited to predict HF-related outcomes.

Aims: We aimed to understand which morphologic or functional parameters are most closely associated with short-term mortality and HF-related hospitalization in patients with HF.

Sandfly Virus Infection in Adana, Türkiye.

We described the clinical and laboratory characteristics of the patients infected by sandfly viruses between August and September 2008 in Adana, Türkiye. The immunofluorescence antibody test (EUROIMMUN Medizinische Labordiagnostika AG, Lübeck, Germany) was used for diagnosis. Antibodies of immunoglobulin M (IgM) type against Cyprus and Sicily species of phleboviruses were detected in 15 patients.

Comparing Medical Training Costs Internationally: A Systematic Review.

Background: Acquiring a thorough understanding of the expenses linked to the education of health sciences students is crucial for effective university planning, budgeting, and overall preparedness. This systematic review aimed to identify and compare the per capita costs associated with educating medical and other health science students internationally-particularly emphasizing the context of Iran.

Methods: A systematic review was conducted in 2023 according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines.

Survival associated with the use of sentinel lymph node in addition to lymphadenectomy in early-stage cervical cancer treated with surgery alone: A sub-analysis of the Surveillance in Cervical CANcer (SCCAN) collaborative study.

Aim: The aim of this study was to assess whether the use of sentinel lymph node (SLN) in addition to lymphadenectomy was associated with survival benefit in patients with early-stage cervical cancer.

Methods: International, multicenter, retrospective study.

Inclusion Criteria: cervical cancer treated between 01/2007 and 12/2016 by surgery only; squamous cell carcinoma, adenocarcinoma, adenosquamous carcinoma, FIGO 2009 stage IB1-IIA2, negative surgical margins, and laparotomy approach.

Complications of Laparoscopic and Open Donor Hepatectomy for Living Donor Liver Transplantation: Single Center Experience.

Objectives: Donor hepatectomy is a major surgery with a relatively safeprofile anda reportedcomplication rate of ~20%. Most complications are non-life threatening and are resolved with conservative measures. However, rare complications may need invasive precautions, ranging from percutaneous interventions to surgeries.

Clinical and Demographic Characteristics of Treatment Requiring Retinopathy of Prematurity in Big Premature Infants in Turkiye: Report No. 1 (BIG-ROP Study).

Introduction: The aim of the study was to analyse the clinical and demographic features of infants with gestational age (GA) of 32-37 weeks and birth weight (BW) of >1,500 g who developed treatment requiring retinopathy of prematurity (ROP).

Methods: Data on the infants with a GA of 32-37 weeks and BW >1,500 g who developed treatment requiring ROP (TR-ROP) were collected retrospectively from the 33 ROP centres in Turkiye. GA, BW, type of hospital, neonatal intensive care units (NICUs) level, presence of an ophthalmologist and neonatologist in the same hospital, length of stay in NICU, duration of oxygen therapy, comorbidities, type of ROP, and timing for TR-ROP development were analysed.