Role and Significance of MicroRNAs in the Relationship Between Obesity and Cancer.

MicroRNAs (miRNAs) are small, noncoding RNAs that are essential for regulating gene expression at the posttranscriptional stage. Recent research shows that miRNAs are crucial in the development of two major global health issues: obesity and cancer, two significant health issues worldwide. This study examines the complex mechanisms by which miRNAs govern vital biological processes, including adipogenesis, cancer, and metabolic dysregulation.

Re-purposing of linagliptin for enhanced wound healing and skin rejuvenation via chitosan- modified PLGA nanoplatforms.

Dipeptidyl peptidase IV (DPP IV) is a multifunctional glycoprotein implicated in the exacerbation of various inflammatory skin conditions, including wounds. Therefore, topical delivery of Linagliptin (LNG)-a DPP IV inhibitor- augmented with Lavender Oil (LO) could offer an excellent repurposed tool for the treatment of inflammatory skin diseases. LNG/ LO loaded chitosan (Cs) -modified Poly (Lactide co-Glycolic Acid) (PLGA) nanoparticles (LNG/LO-Cs/PLGA NPs) were prepared by solvent emulsification-evaporation technique.

Molecular discernment and histopathological features of oncogenic Marek's disease virus among different farmed avian species in Egypt.

Marek's disease virus (MDV) is a highly contagious tumor virus that causes detrimental outbreaks in poultry. Since its initial description, the virus's virulence and acuteness have progressively increased. During this study, we investigated suspected tumorigenic cases of MDV-1 infection among different avian species (chicken, ducks, and turkey) in various Egyptian governorates, including Al-Sharqia, Gharbia, Dakahlia, Port Said, Damietta, and Fayoum, between 2020 and 2023.

Chronic active and chronic inactive hepatitis B virus infection: Comparative study of genetic polymorphism and blood profile measures.

Introduction: Hepatitis B virus (HBV) is a significant cause of chronic hepatitis, leading to liver complications such as cirrhosis and hepatocellular carcinoma. Toll-like receptors (TLRs) are critical in the immune response to HBV. This study investigates the TLR3 1377 C/T polymorphism's association with clinical outcomes in chronic hepatitis B patients.

Optimizing hydrogel performance composed of Japanese pagoda tree extract loaded-gelatin-sodium alginate-polyethylene oxide for biomedical applications: Influence incorporated calcium-based metal organic frameworks and zinc oxide NPs.

Gelatin/sodium alginate/polyethylene oxide hydrogel was synthesized by self-gelation method and utilized to achieve enhanced mechanical strength. Japanese pagoda, tree extracts rich in flavonoids and isoflavonoids was incorporated to enhance tissue repair along with ZnO-NPs to provide the hydrogel with necessary antimicrobial and other desirable biological properties. The inclusion of Ca-BDC MOF enhanced hydrogel matrix by providing more surface area and the presence of calcium ion needed for tissue regeneration.

Pharmacogenetics as a Future Tool to Risk-Stratify Breast Cancer Patients According to Chemotoxicity Potential from the Doxorubicin Hydrochloride and Cyclophosphamide (AC) Regimen.

Studying single-nucleotide polymorphisms (SNPs) in xenobiotic-transporting and metabolizing enzyme genes before administering the doxorubicin hydrochloride and cyclophosphamide (AC) regimen may help optimize breast cancer (BC) treatment for individual patients. : Genotyping specific SNPs on genes encoding for the transport and metabolism of the AC regimen and study their association with its chemotherapeutic toxicity. This prospective cohort study was conducted in two hospitals in Egypt.

Blood Glucose Monitoring Biosensor Based on Multiband Split-Ring Resonator Monopole Antenna.

This paper introduces a novel-shaped, compact, multiband monopole antenna sensor incorporating an irregular curved split-ring resonator (SRR) design for non-invasive, continuous monitoring of human blood glucose levels (BGL). The sensor operates at multiple resonance frequencies: 0.94, 1.

Fungal tyrosinase immobilized on chitosan, calcium alginate, and silica gel for phenol elimination and dye decolorization.

Aspergillus nidulans (AUMC No. 7147) was utilized for tyrosinase (EC 1.14.

SNP's use as a potential chemotoxicity stratification tool in breast cancer: from bench to clinic.

Breast cancer (BC) remains one of the most prevalent malignancies affecting women worldwide, necessitating ongoing research to improve treatment outcomes and minimize adverse effects associated with chemotherapy. This article explores the role of genetic variations, particularly single nucleotide polymorphisms (SNPs), in influencing the efficacy and toxicity of chemotherapeutic agents used in BC treatment. It highlights the impact of polymorphisms in drug metabolism and transport genes, such as UDP-glucuronosyltransferase 1A1 (UGT1A1), carbonyl reductase 1 (CBR1), and ATP-binding cassette multidrug transporter (ABCB1) on the risk of adverse effects, including cardiotoxicity and hematological toxicities.

When oral health affects overall health: biofilms, dental infections, and emerging antimicrobial strategies.

Dental health is a crucial component of overall health, yet it is frequently overlooked in discussions about well-being. This article explores the multifaceted aspects of dental infections, primarily focusing on biofilms formed by pathogenic bacteria such as Streptococcus mutans and Porphyromonas gingivalis. These biofilms contribute to dental caries and periodontal disease, conditions that affect oral health and have systemic consequences.

Alternative medicines in oncology: a focus on natural products against gastric cancer.

There is justification for optimism about the potential contribution of alternative medicines to cancer management, which now ranks as the second leading cause of death globally. Primary carcinogens arise from several sources, including agriculture, industry, and dietary intake. Gastric cancer (GC) significantly affects an individual's health due to its classification as a malignant tumor associated with elevated mortality and morbidity rates.

Enhanced Bioadhesive and Antimicrobial Properties of PVA/Ascorbic Acid Composite with Tannic Acid Synthesized by Gamma Irradiation for Biomedical Applications.

Bioadhesive hydrogels play a crucial role in biomedical applications due to their capacity to adhere to biological surfaces. This study investigates a novel bioadhesive hydrogel system developed from poly(vinyl alcohol) (PVA) and ascorbic acid (AS), cross-linked through gamma irradiation at 7 kGy, and modified with 5 wt % tannic acid (TA). The primary objective was to enhance the hydrogel's bioadhesive, mechanical, and antimicrobial properties.

Chromium and formoterol therapy for obesity-induced asthma in rats.

The development of asthma is impacted by fat. Asthma is more common in obese persons. The purpose of the experimental study is to determine how chromium, formoterol, and their combination can improve the quality of life for obese people with lung anomalies.

Exploring the molecular pathways of miRNAs in testicular cancer: from diagnosis to therapeutic innovations.

Cancer diagnostics highlight the critical requirement for sensitive and accurate tools with functional biomarkers for early tumor detection, diagnosis, and treatment. With a high burden of morbidity and mortality among young men worldwide and an increasing prevalence, Testicular cancer (TC) is a significant death-related cancer. Along with patient history, imaging, clinical presentation, and laboratory data, histological analysis of the testicular tissue following orchiectomy is crucial.

Characterizing Wheat Rhizosphere Bacterial Microbiome Dynamics Under Salinity Stress: Insights from 16S rRNA Metagenomics for Enhancing Stress Tolerance.

Salinity is one of the most important abiotic stress factors affecting wheat production. Salt in the soil is a major environmental stressor that can affect the bacterial community in the rhizosphere of wheat. The bacteria in the plant's rhizosphere promote growth and stress tolerance, which vary by variety and location.

A significant correlation exists between CREBBP and CEBPA gene expression in de Novo adult acute myeloid leukemia.

CREBBP, CEBPA, and DNMT3A are tumor suppressor genes whose dysfunction has been reported in hematologic malignancies. Acute myeloid leukemia (AML) is the most common type of acute leukemia in adults. We aim to assess the expression level of CREBBP, CEBPA, and DNMT3A genes in an Egyptian cohort with AML.

Cilostazol attenuates cisplatin-induced acute liver injury by targeting the SIRT1/AMPK/PGC-1α signaling pathway, with an impact on miRNA-34a.

The dominant chemotherapeutic agent, cisplatin (CP), is widely used to manage various cancer types. Despite its effectiveness, CP use is associated with severe hepatotoxicity. Cilostazol (CSZ), a selective phosphodiesterase III inhibitor, has recently demonstrated remarkable anti-inflammatory and anti-apoptotic properties in different diseases.

Characterization and isolation of 1-aminocyclopropane1-carboxylate (ACC) deaminase-producing, plant growth-promoting rhizobacteria from the rhizosphere of Egyptian wheat cultivars for improved drought resilience.

Drought stress severely damages the growth and development of wheat and leads to lower crop production. The application of plant growth-promoting rhizobacteria (PGPR) is a sustainable approach that enhances plant tolerance to drought. This study investigated whether different bacterial isolates could promote wheat growth under drought conditions.

Chitosan, derivatives, and its nanoparticles: Preparation, physicochemical properties, biological activities, and biomedical applications - A comprehensive review.

Chitosan, derived from the deacetylation of chitin, is the second most widely used natural polymer, valued for its nontoxic, biocompatible, and biodegradable properties. These attributes have driven extensive research into diverse applications of chitosan and various derivatives. The key characteristics of chitosan muco-adhesion, permeability enhancement, drug release modulation, and antimicrobial activity are primarily due to its amino and hydroxyl groups.

Probiotics/prebiotics effect on chicken gut microbiota and immunity in relation to heat-stress and climate-change mitigation.

Heat stress is a serious hazard that threatens world poultry production. The avian gut microbiome plays a critical role in improving nutrient utilization, competing with pathogens, stimulating an immune response, and reducing inflammatory reactions. Hence, the gut microbiome has a positive impact on the host's health which appears in the shape of improved body weight, feed conversion rate, and increased birds' productivity (meat or eggs).

Efficacy of Plyometric Exercises Versus Wii Training on Upper Extremity Function in Children with Unilateral Cerebral Palsy: A Comparative Study.

ObjectivesTo compare between the effects of plyometric exercises versus Wii on upper extremity functions in children with unilateral cerebral palsy (UCP).MethodForty-two children with UCP, ranging in age from 8 to 12 years were allocated to receive plyometric exercises (PLYO -group) or Wii training (Wii-group) for 45 min. both groups received selected occupational therapy programs for 30 min twice a week over 3-month.

Synergistic Effects of Lactobacillus acidophilus and Balanites aegyptiaca in Managing Hyperglycemia, Oxidative Stress, and Inflammation in Diabetic Rats.

Background: Diabetes mellitus is a chronic condition characterized by persistent hyperglycemia, which can lead to serious complications if not managed effectively. Recent interest has grown in exploring the potential of probiotics and prebiotics as complementary therapies. This study investigates the combined effects of the probiotic Lactobacillus acidophilus and the prebiotic Balanites aegyptiaca on blood glucose levels, oxidative stress, and inflammatory markers in an alloxan-induced diabetic rat model.

Evaluating the Use of Inhaled Budesonide and Ipratropium Bromide Combination in Patients at High Risk of Acute Respiratory Distress Syndrome Development: A Randomized Controlled Trial.

There is a scarcity of pharmacological treatments that efficiently address lung injury in individuals experiencing acute respiratory distress syndrome (ARDS). Early inhaled corticosteroids and ipratropium may reduce pulmonary inflammation and injury of the lungs, minimizing the risk of ARDS. This is a double-blinded randomized control trial conducted on patients at risk of ARDS.

Insecticides and testicular health: mechanisms of injury and protective natural products.

In agriculture and public health, insecticides are vital chemicals that help manage diseases and control pests. However, their extensive use has raised concerns about their negative consequences on both humans and animals. Pesticide exposure impacts numerous human organs, including the reproductive system.