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Front Biosci (Landmark Ed)
August 2025
General Surgery, Shanghai Pudong New District Traditional Chinese Medicine Hospital, 200120 Shanghai, China.
Background: The most common endocrine cancer, thyroid carcinoma (TC), has a dismal prognosis when it reaches an advanced stage. Integrin α-2 () has been implicated in cancer progression, influencing both DNA damage and repair mechanisms. However, it is unknown how ITGA2 influences these processes in TC.
View Article and Find Full Text PDFBioorg Chem
September 2025
School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, PR China. Electronic address:
Among the most pervasive malignancies affecting females worldwide, breast cancer is responsible for approximately 2.2 million new diagnoses and over 660,000 fatalities reported annually. Natural products represent an invaluable resource for the identification and development of potential innovative anti-cancer pharmaceuticals.
View Article and Find Full Text PDFPoly[ADP-ribose] polymerase 1 (PARP1) detects DNA strand breaks that occur in duplex DNA and chromatin. We employed correlative optical tweezers and fluorescence microscopy to quantify how single molecules of PARP1 identify single-strand breaks (i.e.
View Article and Find Full Text PDFActa Biochim Biophys Sin (Shanghai)
September 2025
Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Fudan University Cancer Hospital, Shanghai 201315, China.
Tumor radioresistance and severe toxicity make reirradiation for recurrent nasopharyngeal carcinoma (NPC) a significant clinical challenge. This study aims to investigate the ability of the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib to sensitize recurrent NPC cells irradiated with photon or carbon ion (C-ion), and to explore the underlying mechanism of the synergistic promotion of cell death by olaparib and ionizing radiation. The results show that olaparib has significant X-ray and C-ion radiosensitization effects on recurrent NPC cells and the associated HK-RR photon-resistant model.
View Article and Find Full Text PDFTo investigate the biological functions of TOP2A in HCC using bioinformatics and single-cell RNA sequencing (scRNA-seq) methods, and to explore the functional consequences of TOP2A in HepG2 and Huh-7 cells with TOP2A knockdown. This study aims to provide new theoretical insights and potential therapeutic targets for the early diagnosis and targeted treatment of HCC. Through the analysis of single-cell RNA sequencing data, the immunological significance of TOP2A and its relationship with the diagnosis and prognosis of HCC were studied.
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