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PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region.
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Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Background: PPM1D (protein phosphatase Mg⁺/Mn⁺ dependent 1D) is a Ser/Thr phosphatase that negatively regulates p53 and functions as an oncogenic driver. Its gene amplification and overexpression are frequently observed in various malignancies and disruption of PPM1D degradation has also been reported as a cause of cancer progression. However, the precise mechanisms regulating PPM1D stability remain to be elucidated.
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Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia.
Objectives: Proteasomes, multi-subunit proteases, are key actors of cellular protein catabolism and a number of regulatory processes. The detection of subtle proteasome functioning in tumors may contribute to our understanding of the mechanisms of cancer development. The current study aimed to identify the role of low molecular mass protein 2 (LMP2), a proteasome immune subunit, in the development of mouse colon 26 (C26) adenocarcinoma.
View Article and Find Full Text PDFDevelopment and efficacy of dsRNA pesticides targeting the Colorado potato beetle with enhanced stability via chitosan formulations.
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Julius Kühn Institute (JKI) - Federal Research Centre for Cultivated Plant, Institute for Biosafety in Plant Biotechnology, 06484 Quedlinburg, Germany. Electronic address:
The Colorado potato beetle (CPB, Leptinotarsa decemlineata) is a major pest of solanaceous crops and has developed resistance to many conventional insecticides, highlighting the need for novel, environmentally sustainable control strategies. In this study, we evaluated the efficacy of RNA interference (RNAi) targeting the proteasome subunit β5 (PSMB5) gene as a biopesticide approach against CPB larvae. Double-stranded RNA (dsRNA) targeting PSMB5 (a highly specific dsRNA) and Actin (a less specific dsRNA) dsRNA was synthesized and applied via leaf dip assays, either in naked form or formulated with chitosan nanoparticles.
View Article and Find Full Text PDFGenome-wide investigation and functional analysis of 20S proteasome subunits in Locusta migratoria.
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Key Laboratory of Zoological Systematics and Application of Hebei Province, College of Life Sciences, Hebei University, Baoding, China. Electronic address:
The 20S proteasome is a core component of the ubiquitin-proteasome system, participating in various biological processes such as cell cycle regulation, signal transduction, apoptosis, and protein homeostasis. However, its roles in mammals are well-documented, its function in the insect intestine remains largely unexplored. In this study, we identified 14 20S proteasome subunits, including 7 α-subunits and 7 β-subunits in Locusta migratoria, a worldwide agricultural pest.
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