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An expander capsule is a fibrous membrane that forms around an expander after tissue expansion. However, whether the capsule should be removed after the expander is removed remains controversial. The authors aimed to investigate the efficacy and safety of cervical capsulectomy for improving neck mobility and appearance after expanded flap transfer. We retrospectively analyzed patients with cervical scar contractures who underwent expanded flap transfer at our hospital between September 2018 and December 2023. Depending on whether capsulectomy was performed simultaneously with expander removal, the patients were divided into the capsule-retaining (n=50) and capsule-resecting (n=24) groups. The preoperative and postoperative cervicomental angles, neck extension range of motion, postoperative appearance satisfaction, cervical pulling sensation, cervical capsular contracture cords, and postoperative complication rates were compared between the 2 groups to evaluate the efficacy and safety of cervical capsulectomy. Complication rates were not significantly different between the groups (P>0.05). The postoperative improvements in the neck extension range of motion and cervicomental angle were significantly greater, and the appearance satisfaction score was higher in the capsule-resecting group than in the capsule-retaining group. In the capsule-retaining group, 18 (36.0%) patients experienced a significant pulling sensation during neck extension, and 10 (20.0%) patients had capsular contracture cords. The differences between the 2 groups were statistically significant (P<0.05). Cervical capsulectomy is safe and effective for improving neck mobility and appearance after expanded flap transfer.
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http://dx.doi.org/10.1097/SCS.0000000000011907 | DOI Listing |
Br J Haematol
September 2025
Department of Hematology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Refractory cytomegalovirus (CMV) infection is a severe complication following umbilical cord blood transplantation (UCBT). Antiviral agents, the standard first-line therapy, are limited by toxicity and resistance without robust T-cell immunity. We evaluated third-party donor (TPD)-derived CMV-specific T cells (CMVSTs) as a treatment option.
View Article and Find Full Text PDFJ Dermatolog Treat
December 2025
Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Background: Bullous pemphigoid (BP) is a common autoimmune subepidermal bullous disease. Dupilumab, an IL-4/IL-13 inhibitor, represents a novel therapeutic approach for BP, but real-world long-term data in super-elderly patients are limited.
Methods: This retrospective, single-center observational study included super-elderly BP patients (≥80 years) receiving dupilumab monotherapy from September 2022 to September 2024.
Wounds
August 2025
Department of Nursing, Federal University of Ceará, Ceará, Brazil.
Background: Diabetic foot ulcers (DFUs) are a major clinical challenge, particularly among patients with refractory ulcers, that often lead to severe complications such as infection, amputation, and high mortality. Innovations supported by strong clinical evidence have the potential to improve healing outcomes, enhance quality of life, and reduce the economic burden on individuals and health care systems.
Objective: To describe the design of the concurrent optical and magnetic stimulation (COMS) therapy Investigational Device Exemption (IDE) study for refractory DFUs (MAVERICKS) trial.
BMC Biotechnol
September 2025
Faculty of Science, Department of Biotechnology and Food Technology, University of Johannesburg, P.O. Box 17011, Doornfontein, Johannesburg, Gauteng, 2028, South Africa.
Patulin (PAT), a mycotoxin produced primarily by Penicillium expansum, poses significant health risks and frequently contaminates apples and apple-derived products, often exceeding permissible safety limits. This study investigated the potential of orotate phosphoribosyl transferase (URA5) to degrade PAT in apple juice under controlled conditions. PAT degradation was assessed at initial concentrations of 100 µg/L and 250 µg/L, with enzymatic treatment using 0.
View Article and Find Full Text PDFBreast Cancer Res Treat
September 2025
Department of Pharmacy, Duke University Hospital, Durham, NC, USA.
Purpose: Limited data is available assessing sequencing of antibody drug conjugates (ADCs) in patients with hormone receptor-positive (HR +), human epidermal growth factor 2 (HER2)-negative, HER2-low, and triple-negative metastatic breast cancer (MBC), including patients with brain metastases (BrM) or leptomeningeal disease (LMD). This study assesses the efficacy and safety of sequential sacituzumab govitecan (SG) and trastuzumab deruxtecan (T-DXd) in MBC and impact on chemotherapy (CTX).
Methods: This is a single-center, retrospective, cohort study in adult patients with HR + , HER2-negative, or low MBC who received T-DXd and/or SG.