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Acute vestibular syndrome (AVS) is characterized by the sudden onset of dizziness or vertigo, accompanied by nausea, vomiting, gait instability, and nystagmus, lasting for more than 24 hours and often persisting for several days to weeks. Central AVS primarily involves central vestibular structures, such as the brainstem and cerebellum, and is most commonly caused by ischemic stroke in the posterior circulation. When acute posterior circulation infarction presents solely with isolated dizziness or vertigo, without other symptoms of central nervous system damage, it is often misdiagnosed as a peripheral vestibular disorder, this can lead to serious consequences. Therefore, distinguishing between central AVS and peripheral AVS in clinical practice is crucial, as the treatment strategies and prognosis differ significantly. Early identification of central AVS helps in adopting specific diagnostic and therapeutic measures. With advancements in vestibular and oculomotor theories, as well as neuroimaging, it is now possible to rapidly identify and diagnose central AVS of a vascular cause. This article summarizes recent diagnostic strategies, and discusses the progress in clinical and laboratory examinations for central AVS of a vascular cause presenting as isolated vertigo.
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http://dx.doi.org/10.2147/IJGM.S538594 | DOI Listing |
Clin Neurol Neurosurg
September 2025
Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Objective: Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH) is a major cause of morbidity and mortality. Symptoms of DCI can be categorized as temporary or permanent; however, the relationship between DCI and angiographic vasospasm (AVS) remains unclear. Therefore, this study aimed to clarify the relationship between DCI and AVS and to identify the factors associated with DCI in patients with aSAH.
View Article and Find Full Text PDFInt J Gen Med
September 2025
Department of Neurology, Aerospace Center Hospital, Beijing, 100049, People's Republic of China.
Acute vestibular syndrome (AVS) is characterized by the sudden onset of dizziness or vertigo, accompanied by nausea, vomiting, gait instability, and nystagmus, lasting for more than 24 hours and often persisting for several days to weeks. Central AVS primarily involves central vestibular structures, such as the brainstem and cerebellum, and is most commonly caused by ischemic stroke in the posterior circulation. When acute posterior circulation infarction presents solely with isolated dizziness or vertigo, without other symptoms of central nervous system damage, it is often misdiagnosed as a peripheral vestibular disorder, this can lead to serious consequences.
View Article and Find Full Text PDFBioimpacts
August 2025
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia.
Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). CD4 CD25 Tregs, which normally suppress immune responses, exhibit impaired function in MS. Treg-derived extracellular vesicles (EVs) carry immunoregulatory proteins and miRNAs that modulate T-cell activity.
View Article and Find Full Text PDFEJNMMI Res
August 2025
Department of Urology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, P.R. China.
Background: For patients diagnosed with primary aldosteronism (PA) accompanied by bilateral adrenal lesions, identifying optimal candidates for surgical intervention remains a significant clinical challenge. Although adrenal venous sampling (AVS) is currently the gold standard for lateralizing aldosterone hypersecretion, its technical complexity, invasiveness, and interpretive difficulties restrict its widespread adoption. In this study, we aimed to investigate the clinical application of Ga-pentixafor positron emission tomography/computed tomography (PET/CT) as a non-invasive imaging modality in AVS-free surgical decision-making for PA patients with bilateral adrenal lesions.
View Article and Find Full Text PDFEur J Med Res
August 2025
Institute of Nutrition and Diseases and Center for Research, School of Public Health, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Introduction: A significant portion of patients with acute vestibular syndrome (AVS) due to posterior circulation infarction (PCI) is free of non-vestibular signs. A differential diagnosis of this form from that due to vestibular neuritis (VN) can be challenging. We herein aimed to understand whether quantitative eye movement signature could be used to assist such a diagnosis.
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