Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Background And Aims: Breast cancer is the most commonly diagnosed cancer in women worldwide. Several studies have investigated the relationship between breast cancer and specific foods or nutrients, rather than examining an overall dietary pattern. This study aims to investigate the association between breast cancer and the predominant dietary pattern in Ahvaz city.

Methods: This hospital-based case-control study was conducted on 106 women with breast cancer and 107 controls. Dietary intake data were collected using a 147-item food frequency questionnaire. We merged the data on the 147 foods into 20 food groups to identify major dietary patterns. Factor analysis with varimax rotation was then employed to determine the primary dietary patterns. Binary logistic regression was used to assess the association between dietary patterns and breast cancer, with adjustment for potential confounders.

Results: Three dietary patterns were identified: healthy, western, and traditional. The Western dietary pattern was robustly associated with a higher risk of breast cancer in premenopausal women (OR = 4.22; 95% CI: 1.09, 16.31; p = 0.03) in the adjusted model. However, no association was found between a healthy and traditional pattern and breast cancer.

Conclusion: These findings suggest that the Western dietary pattern is positively associated with breast cancer risk in premenopausal Iranian women.

Download full-text PDF

Source
http://dx.doi.org/10.1002/cnr2.70341DOI Listing

Publication Analysis

Top Keywords

breast cancer
32
dietary patterns
20
dietary pattern
16
dietary
10
breast
9
cancer
9
major dietary
8
patterns breast
8
iranian women
8
hospital-based case-control
8

Similar Publications

Introduction: Cutaneous scalp metastases from breast carcinoma (CMBC) represent an uncommon manifestation of metastatic disease, with heterogeneous clinical presentations, including nodular or infiltrative lesions and scarring alopecia (alopecia neoplastica). The absence of standardized diagnostic criteria, particularly for alopecic phenotypes, poses challenges to early recognition of CMBC, which may represent either the first indication of neoplastic progression or a late recurrence.

Materials And Methods: We retrospectively analyzed a multicenter cohort of 15 patients with histologically confirmed CMBC.

View Article and Find Full Text PDF

PRMT1-Mediated PARP1 Methylation Drives Lung Metastasis and Chemoresistance via P65 Activation in Triple-Negative Breast Cancer.

Research (Wash D C)

September 2025

State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, China.

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, characterized by a high propensity for metastasis, poor prognosis, and limited treatment options. Research has demonstrated a substantial correlation between the expression of protein arginine N-methyltransferase 1 (PRMT1) and enhanced proliferation, metastasis, and poor outcomes in TNBC. However, the specific role of PRMT1 in lung metastasis and chemoresistance remains unclear.

View Article and Find Full Text PDF

Purpose: This study aimed to conduct functional proteomics across breast cancer subtypes with bioinformatics analyses.

Methods: Candidate proteins were identified using nanoscale liquid chromatography with tandem mass spectrometry (NanoLC-MS/MS) from core needle biopsy samples of early stage (0-III) breast cancers, followed by external validation with public domain gene-expression datasets (TCGA TARGET GTEx and TCGA BRCA).

Results: Seventeen proteins demonstrated significantly differential expression and protein-protein interaction (PPI) found the strong networks including COL2A1, COL11A1, COL6A1, COL6A2, THBS1 and LUM.

View Article and Find Full Text PDF

A strategy for targeting tumor-associated hypoxia utilizes reductase enzyme-mediated cleavage to convert biologically inert prodrugs to their corresponding biologically active parent therapeutic agents selectively in areas of pronounced hypoxia. Small-molecule inhibitors of tubulin polymerization represent unique therapeutic agents for this approach, with the most promising functioning as both antiproliferative agents (cytotoxins) and as vascular disrupting agents (VDAs). VDAs selectively and effectively disrupt tumor-associated microvessels, which are typically fragile and chaotic in nature.

View Article and Find Full Text PDF

Breast cancer continues to present a major clinical hurdle, largely attributable to its aggressive metastatic behavior and the suboptimal efficacy of standard chemotherapeutic regimens. Cisplatin (CDDP) is a representative platinum drug in the treatment of breast cancer, however, its therapeutic application is often constrained by systemic toxicity and the frequent onset of chemoresistance. Here, we introduce a novel charge-adaptive nanoprodrug system, referred to as PP@, engineered to respond to tumor-specific conditions.

View Article and Find Full Text PDF