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Streptococcal toxic shock syndrome (STSS) is a rare but life-threatening illness characterized by rapid progression to multi-organ failure. This is a case of a middle-aged male patient who initially presented with localized chest wall pain, erythema, vomiting, and diarrhea. These nonspecific symptoms rapidly progressed to systemic shock and multi-organ dysfunction, including acute kidney injury, pleural effusions, demand ischemia of the heart, and the development of a characteristic diffuse, sunburn-like rash. The likely inciting factor was a soft-tissue infection of the chest wall. The patient was treated with broad-spectrum intravenous antibiotics and supportive care in the intensive care unit and step-down unit. Following stabilization after the acute phase, the patient was readmitted due to complications and faced a prolonged recovery. Early symptoms are often vague, and many cases are initially misdiagnosed, highlighting the importance of early diagnostic consideration. This case demonstrates the impact of prompt recognition and timely intervention in STSS. Additionally, it emphasizes the importance of ongoing follow-up due to the risk of long-term sequelae. Clinicians should maintain a high index of suspicion when evaluating patients with rapidly progressing soft-tissue infections and systemic signs.
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http://dx.doi.org/10.7759/cureus.89562 | DOI Listing |
Cureus
August 2025
Internal Medicine, St Luke's Hospital, Easton, USA.
Streptococcal toxic shock syndrome (STSS) is a rare but life-threatening illness characterized by rapid progression to multi-organ failure. This is a case of a middle-aged male patient who initially presented with localized chest wall pain, erythema, vomiting, and diarrhea. These nonspecific symptoms rapidly progressed to systemic shock and multi-organ dysfunction, including acute kidney injury, pleural effusions, demand ischemia of the heart, and the development of a characteristic diffuse, sunburn-like rash.
View Article and Find Full Text PDFJ Ethnopharmacol
September 2025
Center for Biosciences, Federal University of Pernambuco - UFPE, 50670-901, Recife, Brazil.
Ethnopharmacological Relevance: Myrciaria pilosa is a medicinal species traditionally used to treat inflammation, pain and infectious diseases. Essential oils extracted from medicinal plants have recently gained prominence as adjuvants in combating microbial resistance due to their antimicrobial properties and synergistic potential when combined with conventional antibiotics.
Aim Of The Study: Investigated the chemical composition, antibacterial activity, antibiofilm effects, and antibiotic-enhancing properties of Myrciaria pilosa essential oil.
Infection
September 2025
Department of Laboratory Medicine, Minhang Hospital, Fudan University, Shanghai, China.
A 23-month-old boy was admitted to our hospital with onset of fever and paroxysmal cough but progressed to death on Day 9. Streptococcus pyogenes was positive in cerebrospinal fluid and blood by next-generation sequencing, and was cultured from sputum. The isolate was resistant to erythromycin, clindamycin, and tetracycline.
View Article and Find Full Text PDFHaematologica
September 2025
Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA; Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA.
Microbiota disruptions have been associated with short-term complications after allogeneic hematopoietic cell transplantation (alloHCT). However, only a few studies have examined the relationship between dysbiosis and chronic graft-versus-host disease (cGVHD), the main long-term immunologic toxicity of alloHCT. Considering the role of oral microbiota in systemic inflammatory diseases, we evaluated whether oral microbiota at day 28 post-HCT corresponding to clinical recovery from the acute events after transplantation is associated with subsequent cGVHD.
View Article and Find Full Text PDFProbiotics Antimicrob Proteins
September 2025
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu, 214122, People's Republic of China.
Oropharyngeal candidiasis (OPC) commonly occurs in immunocompromised individuals, and enhancing endogenous antimicrobial defenses with probiotics has emerged as an effective prevention strategy. Given the critical role of human β-defensin-2 (HBD-2) in combating Candida albicans infection in the oral cavity, this study aimed to identify oral commensal bacteria promoting HBD-2 production in the host. Thirty-five Streptococcus salivarius strains were screened using the HOK-16B cell line, and two were identified as significantly promoting HBD-2 secretion.
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