Chemical composition, antibiofilm activity, and antibacterial potential in vitro and in a zebrafish model of Myrciaria pilosa Sobral & Couto essential oil.

Ethnopharmacological Relevance: Myrciaria pilosa is a medicinal species traditionally used to treat inflammation, pain and infectious diseases. Essential oils extracted from medicinal plants have recently gained prominence as adjuvants in combating microbial resistance due to their antimicrobial properties and synergistic potential when combined with conventional antibiotics.

Aim Of The Study: Investigated the chemical composition, antibacterial activity, antibiofilm effects, and antibiotic-enhancing properties of Myrciaria pilosa essential oil.

Sepsis Prediction: Biomarkers Combined in a Bayesian Approach.

Sepsis is a serious public health problem. sTREM-1 is a marker of inflammatory and infectious processes that has the potential to become a useful tool for predicting the evolution of sepsis. A prediction model for sepsis was constructed by combining sTREM-1, CRP, and a leukogram via a Bayesian network.

Correlations between new HIV infections and hospital admissions for non-Hodgkin lymphoma in Brazil.

Despite advancements in antiretroviral therapy, human immunodeficiency virus (HIV) infections remain a significant global health challenge. With increasing life expectancy among people living with HIV, the emergence of HIV-related malignancies, notably non-Hodgkin lymphoma (NHL), has become a prominent concern. This study aims to investigate the correlation between new HIV infections and NHL hospitalizations in Brazil from 2010 to 2022.

Chemical Composition, Antimicrobial, and Drug-Potentiating Activities of Extracts From Tocoyena formosa (Cham. & Schltdl.) K.Schum. (Rubiaceae).

Tocoyena formosa is a medicinal species used to treat gastrointestinal disorders, which may include infections. This study analyzed the hexane (HETF) and ethanolic (EETF) extracts of T. formosa to identify their chemical composition and antimicrobial potential.

Effects of Florivory on the Anatomy, Histochemistry and Resource Production of Flowers of Senna aversiflora (Herb.) H.S. Irwin and Barneby.

Florivory directly affects floral structures, especially petals and anthers. The physical damage to these whorls can alter the characteristics of the flowers, compromise their functions, and consequently impact fertility and reduce the reproductive success of the species. We provide the floral anatomical description of Senna aversiflora (Herb.

Impact of iron exposure on Brazilian coral reefs: Acute vs. chronic stress responses.

Prior research has shown that exposure to metals increases corals vulnerability to bleaching by heightened oxidative stress. Understanding the impact of metal contamination on coral health in their natural environmental is crucial. This study investigate the effects of iron (Fe) exposure on Brazilian coral reef species.

Goat Skin (Capra aegagruss Erxleben, 1777): a Promising and Sustainable Source of Collagen.

The aim of the study was to extract and characterize collagen from solid untanned skin waste from the processing of leather in a Capra aegagrus tannery. Using pepsin (SPC), 37 g of collagen were obtained from 100 g of dry weight skin. Characterization took place using SDS-PAGE, FTIR and UV absorption techniques, identifying it as type I collagen.

Parkia pendula polysaccharides have no acute toxicity and prevent ethanol-induced gastric ulcers via downregulation of TBARS, IL-6, and TNF-α and upregulation of SOD, CAT, and IL-10.

We investigated the safety of Parkia pendula exudate polysaccharide (PePp) for acute toxicity and its gastroprotective effect on ethanol-induced gastric ulcers. In the acute toxicity test, animals were treated with a single dose of PePp (2000 mg/kg body weight) and evaluated for behavioral parameters, morbidity and mortality; also biochemical, hematological, and histopathological analysis. The mice were pretreated with a single dose of PePp (10, 25, 50 mg/kg) or ranitidine (80 mg/kg) before gastric ulcer induction with ethanol (99.

Naringenin as potentiator of norfloxacin efficacy through inhibition of the NorA efflux pump in Staphylococcus aureus.

Bacterial resistance is a major challenge in the treatment of Staphylococcus aureus infections, with efflux mechanisms highlighted as reducing the efficacy of antibiotics. In this study, we investigated the potential of naringenin, a natural flavonoid, as an antibacterial agent and efflux pump inhibitor in S. aureus strains 1199 and 1199B.

Molecular epidemiological study of Pseudomonas aeruginosa strains isolated from hospitals in Brazil by MLST and CRISPR/Cas system analysis.

The CRISPR/Cas system defends bacteria and archaea against invasive pathogens, such as phages, establishing an immunological memory from this interaction. Pseudomonas aeruginosa, an opportunistic pathogen, represents a significant public health concern due to its multidrug resistance. This study conducted a molecular epidemiological analysis of clinical isolates of Pseudomonas aeruginosa in Brazil using multilocus sequence typing (MLST) and characterization of CRISPR/Cas system.

The influence of extrinsic apoptosis gene expression on immunological reconstitution of male ART-treated PLHIV.

The primary goal of antiretroviral therapy (ART) is to suppress viral replication to undetectable levels (< 50 copies/mL). Despite achieving complete viral suppression, 10-40% of individuals on ART do not adequately restore their CD4 + T-cell count, being defined as immunological non-responders (INR). Factors such as sex, age at treatment initiation, coinfections, and pre-ART CD4 + T-cell count may influence this insufficient recovery.

Structure-based Virtual Screening and Drug Design Development of Leishmanicidal Pyrimidines.

Leishmaniasis is a neglected disease caused by parasites of the genus Leishmania sp. that causes approximately 1 million cases and 650,000 deaths annually worldwide. Its treatment has several limitations mainly due to high toxicity and clinical resistance, and the search for alternatives is highly desirable.

The Influence of Fluoxetine on the Sensorimotor Function of the Sciatic Nerve in Wistar Rats after Axonotmesis: An Experimental Animal Model.

Background: Fluoxetine, a serotonin reuptake inhibitor antidepressant, raises extracellular serotonin levels and promotes angiogenesis and neurogenesis. Numerous animal models have shown its beneficial effects on recovery from peripheral nerve injury.

Purpose: The primary objective of this study was to analyze the influence of fluoxetine on the sensory-motor function recovery of the sciatic nerve in Wistar rats after axonotmesis.

Lectin from microalgae: Non-toxic to human cells and effective against Leishmania.

New leishmanicidal products are needed for the treatment to be effective, since current drugs are toxic to healthy human/animal cells and have low efficacy against the parasite. Bioactive compounds from microalgae, such as lectins, can be explored as new anti-Leishmania candidates. This study aimed to evaluate the cytotoxic and anti-Leishmania action of the cell extract (CE) and lectin (CVU) from Chlorella vulgaris biomass.

Genome-wide association study analysis of single nucleotide variants in associated with IL-6 inflammatory response in visceral leishmaniasis.

Elevated levels of IL-6 in plasma are associated with the severity of visceral leishmaniasis (VL). The clinical manifestations of VL vary among patients, influenced by host factors and the virulence of the parasite. Considering that severe VL may result from an exaggerated inflammatory response, this study investigated whether IL-6 could serve as a biomarker to identify pro-inflammatory virulence factors.

Purification and characterization of a protease produced by submerged fermentation: Ultrasound-enhanced collagenolytic protease from Streptomyces parvulus.

Proteases are a large group of enzymes in high demand due to their wide and different biotechnological applications mainly in the biomedical field. Ultrasound (US) has been used successfully in several Bioprocesses in biotechnology, such as in the upregulation of enzymatic hydrolysis (biocatalysis). The objective of this work was to purify an enzyme from Streptomyces parvulus and to characterize it through physic-chemical applications including ultrasound effect.

Occult Urinary Incontinence, Diabetes, Obesity, Prolapse Severity, and Type of Surgical Repair as Risk Factors for De Novo Stress Urinary Incontinence in Women Undergoing Surgical Repair of Pelvic Organ Prolapse: A Systematic Review and Meta-Analysis.

Purpose: The International Continence Society and the International Urogynecological Association have not yet standardized the definition of de novo stress urinary incontinence. Recent studies define the development of stress urinary incontinence as occurring after surgical repair of pelvic organ prolapse in previously continent women. The mechanisms that cause de novo stress urinary incontinence are not yet clear.

Emergence and spread of resistant and biofilm-forming Acinetobacter baumannii in critically ill COVID-19 patients.

The COVID-19 pandemic has raised concerns beyond the viral infection itself. Bacterial co-infections, particularly those involving Acinetobacter baumannii, have become a significant worry in critically ill COVID-19 patients. A.

Cardiovascular and Renal Effects Induced by Alpha-Lipoic Acid Treatment in Two-Kidney-One-Clip Hypertensive Rats.

α-Lipoic acid (LA) is an antioxidant of endogenous production, also obtained exogenously. Oxidative stress is closely associated with hypertension, which causes kidney injury and endothelial dysfunction. Here, we evaluated the cardiovascular and renal effects of LA in the two-kidney-one-clip (2K1C) hypertension model.

Prolonged detection of BPV2 in urine and blood of papillomatosis-affected cattle not grazing bracken fern.

BPV-2 infection can cause bladder infections in cattle that, when associated with bracken fern consumption, can progress to cancerous bladder tumors and also present as bovine enzootic hematuria (BEH). This study aimed to evaluate the prolonged natural BPV-2 infection in the blood and urine of cattle, excluding bracken fern consumption. Thirteen Girolando papillomatosis-affected cattle with no bracken fern contact history were monitored for 20 months.