Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Dental mesenchymal stem cells (MSCs) play an essential role in the development of immature permanent teeth. Bacterial infection of the pulp and periapical tissues of immature permanent teeth, the associated oral pathogens, and their virulence factors affect the viability, proliferation, differentiation, and cytokine secretion of MSCs. Bacteria and virulence factors can also trigger an inflammatory response that induces pro-inflammatory cytokine secretion and destroys odontogenic MSCs in the pulp and periapical region, negatively affecting the development of immature permanent teeth. The present study explored the role and mechanisms of oral pathogens associated with pulpitis and apical periodontitis and their virulence factors concerning odontogenic MSCs. The findings can contribute to the clinical treatment of pulpitis and apical periodontitis of immature permanent teeth, providing a theoretical basis for improving its clinical efficacy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414624 | PMC |
| http://dx.doi.org/10.1155/sci/5523197 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Oral Pathogens Associated With Pulpitis and Apical Periodontitis on Odontogenic Mesenchymal Stem Cells.
Stem Cells Int
August 2025
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials
Dental mesenchymal stem cells (MSCs) play an essential role in the development of immature permanent teeth. Bacterial infection of the pulp and periapical tissues of immature permanent teeth, the associated oral pathogens, and their virulence factors affect the viability, proliferation, differentiation, and cytokine secretion of MSCs. Bacteria and virulence factors can also trigger an inflammatory response that induces pro-inflammatory cytokine secretion and destroys odontogenic MSCs in the pulp and periapical region, negatively affecting the development of immature permanent teeth.
View Article and Find Full Text PDF[Digital restoration of molar-incisor hypomineralization of immature permanent teeth: a case report].
Zhonghua Kou Qiang Yi Xue Za Zhi
September 2025
Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University & State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, Chengdu 610041, China.
[Research on the microhardness and microstructure of permanent tooth enamel in childhood].
Hua Xi Kou Qiang Yi Xue Za Zhi
August 2025
Dept. of Pediatric Dentistry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Objectives: Through the investigation of the microhardness and microstructure of permanent tooth enamel at various eruption stages during childhood, this research offers references for the early prevention of childhood dental caries.
Methods: Forty-five premolars extracted due to orthodontic reasons were collected and screened. These premolars were divided into three experimental groups according to the time since eruption: Group A (erupted for 0-1 year), Group B (erupted for 1-3 years), and Group C (erupted for 3-5 years).
[Treatment strategies for immature permanent teeth under general anesthesia].
Hua Xi Kou Qiang Yi Xue Za Zhi
August 2025
Dept. of Pediatric Dentistry, Beijing Stomatological Hospital, Capital Medical University, Beijing 100070, China.
Immature permanent teeth refer to those that have erupted but have not yet formed and matured in terms of shape and structure. The characteristics of their disease onset and treatment methods are different from those of ordinary permanent teeth. Children with special healthcare needs often lack the capacity to cooperate during routine dental procedures, making treatment under general anesthesia (GA) the preferred option.
View Article and Find Full Text PDFContinued Root Formation after a Compound root Fracture in an Immature Permanent Incisor: A Case Report with a 2-year follow-up.
J Dent (Shiraz)
September 2025
Postgraduate Student of Endodontics, Dept. of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
While traumatic injuries in the young permanent dentition are frequent, root fractures are relatively rare, particularly in immature teeth. This study reports the case of a 7-year-old boy who fell off a bicycle. Radiographic examination showed an immature right upper central incisor with fractures in the middle and along the root in an oblique and horizontal direction.
View Article and Find Full Text PDF