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Background: Undernutrition remains a persistent public health concern among young children in Palestine, shaped by a range of socioeconomic and dietary factors. This study applies a Structural Equation Modeling (SEM) approach to explore both direct and indirect determinants of child growth among children aged 6-59 months in the West Bank.
Methods: Data were drawn from a 2022 cross-sectional survey involving 300 children selected from 1,400 households. Child growth was assessed using anthropometric indicators (HAZ, WAZ, MUAC) and dietary adequacy via the Mean Nutrient Inadequacy Ratio (MNIR). Latent constructs were developed for socioeconomic status, food insecurity, dietary intake (macro- and micronutrients), feeding practices, neonatal health, and food availability. SEM was used to examine interrelationships and the pathways influencing child nutritional status.
Results: Descriptive analysis showed substantial variation in undernutrition and nutrient intake across regions, family size, and parental education. SEM results showed that macronutrient intake had the strongest direct effect on child growth, followed by socioeconomic status and neonatal health. Infant feeding practices and micronutrient intake also contributed positively, though their effects were primarily indirect. Food availability acted as a significant mediator, linking structural access issues to poor dietary diversity and feeding behavior. The model demonstrated good fit across multiple indices.
Conclusion: Child nutrition in Palestine is shaped by interrelated determinants of dietary intake, caregiver practices, food access, and early-life health conditions. Effective interventions must target both nutritional quality and the broader social and environmental context to improve growth outcomes. SEM offers a powerful framework to understand these pathways and guide evidence-based policy design.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416647 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0331579 | PLOS |
PLoS One
September 2025
Laboratory of Microbiology, Wageningen University, Wageningen, The Netherlands.
Immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) is an immune-mediated reaction to cow's milk (CM). Non-IgE-mediated CMA resolves in most children in the first years of life, whereas IgE-mediated CMA outgrowth is often later or not at all. The exact mechanisms underlying resolution of IgE-mediated CMA are not fully understood.
View Article and Find Full Text PDFBrain
September 2025
Departamento de Fisiología, Facultad de Medicina, Universidad de Granada, 18016 Granada, Spain.
Primary coenzyme Q (CoQ) deficiency is a mitochondrial disorder with variable clinical presentation and limited response to standard CoQ10 supplementation. Recent studies suggest that 4-hydroxybenzoic acid (4-HBA), a biosynthetic precursor of CoQ, may serve as a substrate enhancement treatment in cases caused by pathogenic variants in COQ2, a gene encoding a key enzyme in CoQ biosynthesis. However, it remains unclear whether 4-HBA is required throughout life to maintain health, whether it offers advantages over CoQ10 treatment, and whether these findings are translatable to humans.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
September 2025
Department of Zoology and Biodiversity Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Organisms often face multiple selective pressures simultaneously (e.g., mine tailings with multiple heavy metal contaminants), yet we know little about when adaptation to one stressor provides cross-tolerance or cross-intolerance to other stressors.
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September 2025
School of Architecture and Design, Harbin Institute of Technology, Harbin, 150001, China.
Street-level environments play a vital role in children's development by promoting their physical activity, cognitive growth, and overall development. This study systematically reviews the measurement tools available to assess street environments according to children's needs. This systematic review was conducted according to the PRISMA-COSMIN guidelines.
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Scottish Rite for Children.
Background: Legg-Calvé-Perthes disease (LCPD) is a pediatric hip disorder characterized by idiopathic avascular necrosis of the femoral head. Although its etiology remains unclear, frequent observations of short stature and delayed skeletal maturation have suggested disturbance of systemic growth regulation, particularly involving the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis. This study evaluates the impact of GH deficiency (GHD) and timing of GH therapy (GHT) on radiographic progression and femoral head morphology in LCPD.
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