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Cardioneuroablation is a relatively new method to treat asystolic reflex syncope. The short- and mid-term efficacy ranges between 70% and 94%. Although the method is increasingly used worldwide, there are many unresolved issues associated with the use of this technique. One such issue is the correct identification of optimal candidates for cardioneuroablation. This article reviews the demographic, clinical and procedural parameters that may be of value in predicting the efficacy of cardioneuroablation.
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http://dx.doi.org/10.15420/aer.2025.25 | DOI Listing |
Arrhythm Electrophysiol Rev
August 2025
Department of Cardiology, Medical Centre for Postgraduate Education, Grochowski Hospital Warsaw, Poland.
Cardioneuroablation is a relatively new method to treat asystolic reflex syncope. The short- and mid-term efficacy ranges between 70% and 94%. Although the method is increasingly used worldwide, there are many unresolved issues associated with the use of this technique.
View Article and Find Full Text PDFJ Physiol
September 2025
Faculty of Medicine, Department of Pathophysiology, Masaryk University, Brno, Czech Republic.
Severe aortic stenosis (AS) is a recognized risk factor for sudden cardiac death (SCD). Although ventricular tachyarrhythmias are the most common immediate cause of SCD, the majority of cases of SCD in patients with severe AS exhibited bradyarrhythmia as the primary rhythm. Enhanced activation of left ventricular baroreceptors (Bezold-Jarisch reflex) has been implicated in the pathogenesis of syncope in patients with AS.
View Article and Find Full Text PDFHerzschrittmacherther Elektrophysiol
August 2025
Klinik für Kardiologie, Angiologie und Intensivmedizin, Campus Mitte, Deutsches Herzzentrum der Charité, Charitéplatz 1, 10117, Berlin, Germany.
The case of a 36-year-old female patient with recurrent reflex syncope characterized by predominant cardioinhibition and episodes of asystole lasting up to 9 s, as documented by an implantable loop recorder, is reported. Given her young age and symptomatic burden, cardioneuroablation (CNA) was performed without complications as an alternative to pacemaker implantation, in accordance with European Heart Rhythm Association (EHRA) recommendations. In this case, CNA has shown to be an effective and safe treatment option for managing recurrent cardioinhibitory reflex syncope.
View Article and Find Full Text PDFAnn Med Surg (Lond)
July 2025
Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi Gakuin University, Nagoya-shi, Aichi-ken, Japan.
Introduction And Importance: The trigeminocardiac reflex (TCR) is an uncommon but significant complication that can arise during orthognathic surgery.
Case Presentation: We present two cases of TCR-induced bradycardia and hypotension during such procedures. In the first case, bradycardia was noted following a controlled downward fracture of the maxilla.
Adv Sci (Weinh)
August 2025
Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, LS2 9JT, UK.
The discovery of PIEZO1 channels as robust, rapidly activating, electrically transducing mechanical force sensors of endothelial biology led to intense research efforts that have transformed the appreciation and understanding of pivotal relationships between mechanical forces and cardiovascular health. This narrative review of the scientific literature highlights discoveries about the PIEZOs, PIEZO1 and PIEZO2, in vascular biology from the embryo to adult stages including in vascular and valve formations, vascular expansion and arrest, lymphatic and venous integrity, blood pressure regulation, the aortic baroreceptor reflex, microvascular density for muscle and physical exercise capabilities and the regulation of lipid homeostasis, cerebral hyperemia and leukocyte extravasation. Concepts are discussed for how the channels work at the molecular level and integrate with other cell components and how they signal downstream for appropriate tissue responses.
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