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Polymyositis with concomitant scleroderma is a rare, progressive condition with profound consequences if not addressed promptly. Severity and symptom presentation varies between patients, and much is unknown about how best to treat overlapping connective tissue diseases. This case discusses the rare presentation, medical evaluation, and successful treatment of a 46-year-old woman with excessive muscle atrophy, weakness, and tissue fibrosis, who was diagnosed with overlapping connective tissue disorder after extensive work up that included a muscle biopsy, skin punch biopsy, and autoantibody lab work. This patient recovered well with the use of mycophenolate mofetil demonstrating promising results for similar patients and offering insight into potential methods of evaluation and medical management. Studying cases like this one give providers more knowledge about overlapping connective tissue disease and how to best diagnose and manage them.
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http://dx.doi.org/10.1177/11795441251370380 | DOI Listing |
Toxicon
September 2025
School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China; Hunan Provincial Key Laboratory of Drugability and Preparation Modification of TCM, Changsha 410208, China. Electronic address:
Background: Aristolochic acids (AA) are naturally occurring carcinogens found in traditional herbal medicines derived from Aristolochia species. This study explores the potential link between AA and hepatocellular carcinoma (HCC), aiming to uncover key molecular targets driving AA-induced hepatocarcinogenesis.
Methods: Toxicogenomic databases were used to identify AA-related toxicological profiles and targets, which were integrated with HCC-associated gene datasets.
Clin Med Insights Arthritis Musculoskelet Disord
September 2025
Department of Surgery, University of Arkansas for Medical Sciences, Fayetteville, AR, USA.
Polymyositis with concomitant scleroderma is a rare, progressive condition with profound consequences if not addressed promptly. Severity and symptom presentation varies between patients, and much is unknown about how best to treat overlapping connective tissue diseases. This case discusses the rare presentation, medical evaluation, and successful treatment of a 46-year-old woman with excessive muscle atrophy, weakness, and tissue fibrosis, who was diagnosed with overlapping connective tissue disorder after extensive work up that included a muscle biopsy, skin punch biopsy, and autoantibody lab work.
View Article and Find Full Text PDFAm J Lifestyle Med
September 2025
Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, USA (BB, EA, ET, DO, KO).
Racial and ethnic minority populations experience a higher rate of diet-related disparities compared to the general population. Culinary medicine interventions have the potential to help improve health equity among disadvantaged groups. We examined behavioral, anthropometric, and laboratory outcomes of culinary medicine interventions among racial and ethnic minority and underrepresented populations.
View Article and Find Full Text PDFBiol Psychiatry Cogn Neurosci Neuroimaging
September 2025
University of Illinois at Chicago, Department of Psychiatry. Electronic address:
Background: Late-life depression (LLD) is associated with negative outcomes including high rates of recurrence and cognitive decline. However, the neurobiological changes influencing such outcomes in LLD are not well understood. Disequilibrium in large-scale brain networks may contribute to LLD-related cognitive decline.
View Article and Find Full Text PDFLancet Rheumatol
September 2025
Leeds Institute for Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK; NIHR Leeds Biomedical Research Centre, Leeds, UK.
Vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic (VEXAS) syndrome is a newly identified disorder caused by an acquired monogenic somatic UBA1 gene mutation, affecting nuclear and cytoplasmic ubiquitination. This mutation triggers immune dysregulation, leading to diverse clinical and pathological features resembling inflammatory rheumatic diseases. Blood abnormalities stem from myeloid precursor dysfunction, presenting as elevated concentrations of inflammatory markers and cytokines, leukopenia, and macrocytosis.
View Article and Find Full Text PDF