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The construction sector faces the daunting task of meeting growing construction demand with a 'zero-emission resource pool'-materials that are compatible with a near-future zero-emissions economy. Most decarbonisation roadmaps and scenario analyses for the sector depend heavily on high-risk technologies such as carbon storage that have not yet been deployed at significant scale, or favour recycling whilst overlooking likely constraints from limited supplies of zero-emissions electricity. This paper therefore provides a first critical review of options to supply construction materials in the UK with realistic expectations about the availability of carbon storage, zero-emissions electricity and zero-emissions transport. The paper focuses on nine key construction materials-concrete, steel, aluminium, structural glass, timber, earth, stone, lime and straw. We conclude that the zero-emissions resource pool includes virgin bio-based materials, limited by the availability of productive land, virgin earth and stone, limited by local geology and transportation, recycled materials, limited by the availability of scrap and emission-free electricity, and reused components, limited by availability and refurbishment potential. This points to the need for a revision to the national construction strategy and a range of entrepreneurial opportunities in delivering the services of construction within a reduced material budget.
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http://dx.doi.org/10.1007/s44150-025-00171-1 | DOI Listing |
Mol Pharm
September 2025
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Tissue factor (TF) has emerged as a promising target for the diagnosis and treatment of hepatocellular carcinoma (HCC). However, there is limited data available on TF-related PET imaging for longitudinal monitoring of the pathophysiological changes during HCC formation. Herein, we aimed to explore the TF-expression feature and compare a novel TF-targeted PET probe with F-FDG through longitudinal imaging in diethylnitrosamine (DEN)-induced rat HCC.
View Article and Find Full Text PDFJCO Glob Oncol
May 2025
Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Purpose: Breast cancer remains a significant public health challenge globally, as well as in India, where it is the most frequently diagnosed cancer in females. Significant disparities in incidence, mortality, and access to health care across India's sociodemographically diverse population highlight the need for increased awareness, policy reform, and research.
Design: This review consolidates data from national cancer registries, global cancer databases, and institutional findings from a tertiary care center to examine the epidemiology, clinical challenges, and management gaps specific to India.
Neurology
October 2025
Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, Full Member of European Reference Network on Rare and Complex Epilepsies - EpiCARE, Rome, Italy.
Objectives: Neuronal ceroid lipofuscinosis type 3 (CLN3) is a rare lysosomal storage disorder characterized by progressive neurodegeneration. No disease-modifying treatments are currently available. Miglustat, a substrate reduction therapy, has shown preclinical efficacy in CLN3 models (conference abstract).
View Article and Find Full Text PDFJ Pediatr Hematol Oncol
September 2025
Nuclear Medicine, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India.
Pediatric pancreatic neuroblastoma is a rare cancer in children, with only limited cases available in the literature. We report a case of a 4-year-old girl diagnosed with high-risk pancreatic neuroblastoma. The girl was treated with induction chemotherapy followed by autologous stem cell transplant and maintenance with 13-cis-retinoic acid.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, United States of America.
Research into the mechanisms underlying neuromodulation by tES using in-vivo animal models is key to overcoming experimental limitations in humans and essential to building a detailed understanding of the in-vivo consequences of tES. Insights from such animal models are needed to develop targeted and effective therapeutic applications of non-invasive brain stimulation in humans. The sheer difference in scale and geometry between animal models and the human brain contributes to the complexity of designing and interpreting animal studies.
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