Light does not phase shift the circadian clock of subcutaneous adipose tissue in vitro.

NPJ Biol Timing Sleep

Healthy Living Spaces Lab, Institute for Occupational, Social and Environmental Medicine, Medical Faculty, RWTH Aachen University, Aachen, Germany.

Published: September 2025


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Article Abstract

The retinal photopigment melanopsin is also expressed in subcutaneous white adipose tissue (scWAT). Through melanopsin, light can modulate scWAT metabolism, but its impact on circadian phase is unclear. In vitro exposure of murine scWAT to bright light at different times over 24 h did not elicit phase shifts, unlike the response to corticosterone. This finding suggests that the direct impact of bright light on scWAT metabolism occurs in a circadian-independent manner.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411236PMC
http://dx.doi.org/10.1038/s44323-025-00048-yDOI Listing

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