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Encapsulated papillary carcinoma (EPC) is an invasive carcinoma which shows papillary architecture within a thickened fibrous capsule. Multiple studies have shown that this tumor follows an indolent course with excellent prognosis, and as such, it is recommended that it be staged as in situ lesions. It is an uncommonly encountered tumor most often diagnosed in postmenopausal females. As breast cancer in males is overall rare, available data on diagnosis, management, and outcomes of EPC in males is limited. Typically, cases of EPC that present with advanced stage and/or lymph node metastases show an associated invasive process. We present a case of pure EPC in a male patient with associated skin ulceration and positive lymph nodes, leading to a final stage of ypT4bN1a. The present report underscores the indolent nature of EPC, even when diagnosed at an advanced stage.
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http://dx.doi.org/10.1155/crip/6518104 | DOI Listing |
Case Rep Pathol
August 2025
Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.
Encapsulated papillary carcinoma (EPC) is an invasive carcinoma which shows papillary architecture within a thickened fibrous capsule. Multiple studies have shown that this tumor follows an indolent course with excellent prognosis, and as such, it is recommended that it be staged as in situ lesions. It is an uncommonly encountered tumor most often diagnosed in postmenopausal females.
View Article and Find Full Text PDFJ Clin Pathol
September 2025
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA, USA
Aims: Papillary carcinoma diagnosed in core needle biopsy (CNB) refers to carcinoma with papillary features but no definitive invasion, including papillary ductal carcinoma in situ (DCIS), papilloma with DCIS, encapsulated papillary carcinoma (EPC) and solid papillary carcinoma (SPC). This study assesses the upgrade rate of papillary carcinoma in CNB and supports the use of 'papillary carcinoma' as an umbrella term.
Methods: A retrospective review identified 41 CNB cases of non-invasive papillary carcinoma with subsequent excision (2011-2018).
Breast Cancer
September 2025
Division of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Background: Morphological features of tumors can reflect the biological behavior of breast carcinoma; however, a consensus macroscopic classification remains elusive. In this study, we aimed to elucidate the relationship between macroscopic morphology and biological behavior of breast carcinoma.
Methods: We evaluated 328 post-operative breast carcinomas, stratifying them by hormone receptor/human epidermal growth factor receptor 2 (HER2) status (luminal-like, luminal-HER2, HER2-positive [non-luminal], triple-negative), and morphological patterns.
Endocr Pathol
September 2025
Department of Pathology, Medical Faculty, Institute of Molecular Pathology and Immunology (IPATIMUP), i3S-Institute for Research & Innovation in Health, University of Porto, Porto, 4200-135, Portugal.
Thyroid lesions associated with DICER1 syndrome include multifocal hyperplastic and benign neoplastic proliferations (follicular nodular disease) with characteristic macrofollicular and/or intrafollicular centripetal papillary growth patterns, frequently associated with atrophic and involutional changes. There are also well-differentiated thyroid carcinomas showing intermediate-type nuclei, sometimes combining high-grade areas (tumor-in-tumor pattern) and poorly differentiated carcinomas. Here, for the first time, we describe an encapsulated follicular cell thyroid tumor showing a mixed follicular and morular growth pattern, which presented in an 11-year-old girl with follicular nodular disease and a constitutional (germline) DICER1 p.
View Article and Find Full Text PDFCureus
August 2025
Biomedical Sciences, Universidad Juárez del Estado de Durango, Durango, MEX.
Diffuse neurofibroma is a benign peripheral nerve sheath tumor characterized by non-encapsulated spindle cell proliferation within the dermis and subcutaneous tissue. Although usually associated with neurofibromatosis type I (NF1) and preferentially located in the head and neck of pediatric patients, rare instances of sporadic solitary cases in atypical locations have been documented. We describe the case of a 30-year-old female with no personal or familial signs of neurocutaneous syndromes who presented with a two-year history of a slowly enlarging, asymptomatic plaque on the left scapular region.
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