Publications by authors named "Abdulwahab M Ewaz"
Aims: Papillary carcinoma diagnosed in core needle biopsy (CNB) refers to carcinoma with papillary features but no definitive invasion, including papillary ductal carcinoma in situ (DCIS), papilloma with DCIS, encapsulated papillary carcinoma (EPC) and solid papillary carcinoma (SPC). This study assesses the upgrade rate of papillary carcinoma in CNB and supports the use of 'papillary carcinoma' as an umbrella term.
Methods: A retrospective review identified 41 CNB cases of non-invasive papillary carcinoma with subsequent excision (2011-2018).
Purpose: Ki-67 expression levels in breast cancer have prognostic and predictive significance. Therefore, accurate Ki-67 evaluation is important for optimal patient care. Although an algorithm developed by the International Ki-67 in Breast Cancer Working Group (IKWG) improves interobserver variability, it is tedious and time-consuming.
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- The study aimed to assess how consistently breast pathologists can evaluate low HER2 expression in metastatic breast cancer using trastuzumab deruxtecan and to create a better assessment method.
- Six pathologists reviewed 106 cancer slides, with their agreement measured before and after training using a modified Ki-67 algorithm.
- Results showed improved agreement among pathologists, but considerable challenges remain, indicating a need for a more reliable evaluation method for HER2-low breast cancer.