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Lomentospora prolificans (formerly Scedosporium prolificans) is an emerging fungal pathogen, affecting both immunocompromised and immunocompetent individuals. Treatment is difficult due to intrinsic resistance against multiple anti-fungal agents. We describe five patients with L. prolificans infections attending a tertiary care center in South India. Out of the 5 patients, 4 patients presented with deep seated infection, and 1 with disseminated disease. Risk factors included uncontrolled diabetes mellitus, advanced HIV infection, T cell lymphoblastic leukemia, carcinoma breast, and immunosuppressant therapy. L. prolificans as an important causative agent of deep seated and disseminated mycoses among immunocompromised patients.
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http://dx.doi.org/10.1016/j.ijmmb.2025.100957 | DOI Listing |
Indian J Med Microbiol
September 2025
Department of Clinical Microbiology, Christian Medical College, Vellore,632004, Tamil Nadu. Electronic address:
Lomentospora prolificans (formerly Scedosporium prolificans) is an emerging fungal pathogen, affecting both immunocompromised and immunocompetent individuals. Treatment is difficult due to intrinsic resistance against multiple anti-fungal agents. We describe five patients with L.
View Article and Find Full Text PDFPLoS Negl Trop Dis
September 2025
Department of Dermatology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Chromoblastomycosis (CBM) and mycetoma, as implantation mycoses, have been listed as neglected tropical diseases (NTDs) by the World Health Organization. The concurrent occurrence of these two NTDs in a single patient is extremely rare. A 69-year-old female patient presented with papules on the dorsum of her left hand for over 5 months and nodules on the left lower limb accompanied by ulceration and pain for 20 days.
View Article and Find Full Text PDFMed Mycol J
August 2025
Department of Diagnostic Pathology, Hashimoto Municipal Hospital.
Although culture remains the gold standard for detecting etiologic fungal organisms, histopathology plays a crucial role in confirming fungal infections by demonstrating these organisms in tissue. The morphology of fungi in tissue can often be specific to their genus or order, aiding pathological diagnosis. However, the presence of atypical fungal forms can complicate identification.
View Article and Find Full Text PDFPathogens
August 2025
Department of Biology, Parasitology and Pharmaceutical Botany, Pomeranian Medical University in Szczecin, Powstanców Wielkopolskich 72, 70-111 Szczecin, Poland.
The shortage of organs for use in transplantation has contributed to the development of an international commercial market for organ transplantation. Unfortunately, transplant tourism (TT) is associated with risks for surgical complications, poor graft outcome, increased mortality, and infectious complications. TT increases the risk of several viral (HIV and hepatitis B and C viruses), bacterial ( sp.
View Article and Find Full Text PDFJ Clin Med
August 2025
Unit of Respiratory Disease, Cardiothoracic and Vascular Department, IRCCS Policlinico San Matteo, Viale Golgi 19, 27100 Pavia, Italy.
is a filamentous fungus increasingly recognized as an opportunistic pathogen in immunocompromised hosts, though rare infections in immunocompetent individuals with structural lung disease have been reported. Its diagnosis and management remain challenging due to non-specific clinical presentation and intrinsic resistance to multiple antifungal agents. We report the case of a 66-year-old immunocompetent woman with idiopathic bilateral non-cystic fibrosis bronchiectasis, who presented with subacute cough and increased sputum production.
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