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Background: Chronic nonspecific neck pain (CNSNP) is a prevalent and complex condition. Although many studies have evaluated the effectiveness of transcutaneous electrical nerve stimulation (TENS), interferential current (IFC), therapeutic exercise (TE), and manual therapy (MT) individually, this study aimed to determine whether adding IFC and/or TENS to a Multimodal Therapeutic Intervention Program (MTIP) would produce better outcomes than the MTIP alone concerning functional capacity, pain intensity, pain catastrophising, kinesiophobia and overall perceived effect in individuals with CNSNP.
Methods: Seventy-five individuals with CNSNP were randomly assigned to one of three groups: MTIP, MTIP + IFC, or MTIP + TENS. Interventions were conducted over 8 weeks. Outcomes were assessed at baseline, post-intervention, and at a 1-month follow-up. The primary outcome was the Neck Disability Index (NDI). Secondary outcomes included the Numeric Pain Rating Scale (NPRS) at rest and during movement, the Pain-Related Catastrophizing Thoughts Scale (PRCTS), the Tampa Scale for Kinesiophobia (TSK), the Copenhagen Neck Functional Disability Scale (CNFDS), the WHO Disability Assessment Schedule (WHODAS 2.0), and the Global Perceived Effect Scale (GPES).
Results: No significant differences were observed between groups for the primary outcome. For secondary outcomes, the MTIP group showed improved results for NPRS-m and CNFDS. Additionally, MTIP was superior to MTIP + IFC for NPRS-r post-intervention, while MTIP + TENS outperformed both groups at follow-up. No significant differences were found for GPES, and none of the differences reached clinical significance.
Conclusions: The addition of IFC and/or TENS to an MTIP did not enhance clinical outcomes in individuals with CNSNP.
Significance: The results of this study assist clinicians in making informed decisions regarding the selection of therapeutic resources for managing chronic nonspecific neck pain. They also support researchers in refining and conducting new studies focused on improving the implementation of multimodal intervention protocols. Additionally, these findings help individuals with chronic nonspecific neck pain better understand which interventions may be most appropriate to include in their rehabilitation process.
Trial Registration: NCT05400486.
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http://dx.doi.org/10.1002/ejp.70121 | DOI Listing |
Drug Metab Dispos
July 2025
Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington; Division of Molecular Biosciences, Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, New York
Hydromorphone is a highly potent opioid used to treat severe chronic pain. It is metabolized primarily by UDP-glucuronosyltransferase (UGT)2B7 to form the inactive hydromorphone-3-glucuronide. Given that previous studies have shown that the major cannabinoids, Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD), inhibit several UGT enzymes, the objective of the present study was to determine the inhibitory potential of major cannabinoids and their metabolites on UGT-mediated hydromorphone metabolism.
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August 2025
Yale University, Section of Digestive Diseases, New Haven, Connecticut, USA.
Purpose Of Review: Crohn's disease is a chronic, relapsing and remitting inflammatory process that can involve the entire length of the gastrointestinal tract. Upper gastrointestinal involvement (UGI) in Crohn's disease is present in up to 15% of patients and can present as a diagnostic challenge given nonspecific symptoms and overlapping disease entities. This review provides an update on diagnosing and risk stratifying UGI-CD.
View Article and Find Full Text PDFNurs Res
September 2025
College of Nursing & Institute of Nursing Research, Korea University, Seoul, South Korea.
Background: Existing research fails to address the complex nature of nonspecific chronic lower back pain (cLBP ) despite its detrimental effect on economic, societal, and medical expenditures.
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Methods: This study was composed of two phases: (a) lab and field usability testing for a gamified mobile device application; and (b) a pilot study employing a one-arm pre-test and post-test design among adults aged 18-60 years with nonspecific cLBP.
Cureus
August 2025
Investigation, Hospital Regional de Alta Especialidad de Ixtapaluca, Mexico City, MEX.
Splenic pseudocysts represent an uncommon condition in abdominal surgery, generally resulting from trauma, infection, or ischemic processes. Histologically, they are characterized by the absence of an epithelial lining; that is, they lack the inner layer of cells typically found in true cysts. Its clinical presentation is non-specific, commonly manifesting with abdominal pain, early satiety, or alterations in bowel habits, which lead to late or incidental diagnoses through imaging studies.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Background: Chronic nonspecific low back pain (CNSLBP) is associated with thoracolumbar fascia (TLF) dysfunction. However, the structural effects of Gua Sha, a Traditional Chinese Medicine technique, remain unclear. This study aimed to explore the acute and short-term effects of Gua Sha therapy on TLF thickness, pain intensity, and related physiological parameters in patients with CNSLBP.
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