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Introduction: Immunoglobulin G4-related disease is a systemic fibroinflammatory disorder that affects the kidney, presenting as an immunoglobulin G4-related inflammatory pseudotumor. These renal inflammatory pseudotumors are usually solid, and cystic presentations have not been previously described.
Case Presentation: We report a 77-year-old man who presented with a Bosniak category III renal cystic mass and periaortic fibrous thickening. Increased serum immunoglobulin G4 levels indicated immunoglobulin G4-related disease; however, a malignant process could not be definitively ruled out. The patient underwent robot-assisted radical nephrectomy, and histopathologic assessment confirmed a cystic immunoglobulin G4-related inflammatory pseudotumor.
Conclusion: This is the first report of a renal immunoglobulin G4-related inflammatory pseudotumor with cystic features. Increased knowledge of immunoglobulin G4-related disease as a potential cause of cystic renal lesions, particularly in patients with systemic findings, may improve preoperative diagnosis.
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http://dx.doi.org/10.1002/iju5.70074 | DOI Listing |
IJU Case Rep
September 2025
Department of Urology Saitama Medical Center, Saitama Medical University Kawagoe Japan.
Introduction: Immunoglobulin G4-related disease is a systemic fibroinflammatory disorder that affects the kidney, presenting as an immunoglobulin G4-related inflammatory pseudotumor. These renal inflammatory pseudotumors are usually solid, and cystic presentations have not been previously described.
Case Presentation: We report a 77-year-old man who presented with a Bosniak category III renal cystic mass and periaortic fibrous thickening.
Eur Heart J Cardiovasc Imaging
September 2025
Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Cureus
August 2025
Department of Neurosurgery, Toho University, Tokyo, JPN.
Herein, we report a case of immunoglobulin G4-related disease (IgG4-RD) that required differentiation from meningioma and dural metastasis based on neuroradiological imaging results, particularly focusing on magnetic resonance spectroscopy (MRS) and cerebral angiography findings. The patient was a 67-year-old woman who presented with left lower-limb weakness. She had been diagnosed with breast cancer 11 years earlier and was treated with surgical resection, followed by hormone therapy.
View Article and Find Full Text PDFImmun Inflamm Dis
August 2025
Department of Gastroenterology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China.
Background: Multiple myeloma (MM) is a common malignant tumor of the hematological system caused by the malignant proliferation of plasma cells, characterized by the production of M proteins and CRAB symptoms. Among them, the Immunoglobulin G MM is the most common, while the IgG4-MM is extremely rare. Smoldering multiple myeloma refers to a state where there are no clinical symptoms.
View Article and Find Full Text PDFWorld J Clin Cases
September 2025
Department of Infectious Diseases, People's Hospital of Pu'er City, Pu'er 665000, Yunnan Province, China.
Background: Immunoglobulin G4-related disease (IgG4-RD) is a persistent and progressive autoimmune condition marked by inflammation and fibrotic changes in the affected tissues. Cases of IgG4-RD causing pulmonary lesions are relatively rare, and some may be misdiagnosed as pulmonary tuberculosis.
Case Summary: In this report, we present an uncommon instance of IgG4-related lung disease, which was diagnosed through lung tissue biopsy conducted puncture.