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An 89-year-old man with a history of lung cancer surgery underwent a positron emission tomography-computed tomography (PET/CT) scan for suspected recurrence. The patient agreed to a six-hour fast before the scan. The PET/CT scan showed extensive accumulation in the skeletal muscles throughout the body. A large amount of content was found in his stomach. Despite his claim to have fasted before the scan, the patient seemed to have eaten. Eating before a PET/CT scan will significantly impair image quality. Fasting is essential before the procedure.
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http://dx.doi.org/10.7759/cureus.89303 | DOI Listing |
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Geriatric Pulmonary and Critical Care Medicine, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha 410008.
Objectives: Non-small cell lung cancer (NSCLC) is associated with poor prognosis, with 30% of patients diagnosed at an advanced stage. Mutations in the and genes are important prognostic factors for NSCLC, and targeted therapies can significantly improve survival in these patients. Although tissue biopsy remains the gold standard for detecting gene mutations, it has limitations, including invasiveness, sampling errors due to tumor heterogeneity, and poor reproducibility.
View Article and Find Full Text PDFBr J Haematol
September 2025
First Department of Medicine-Hematology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
Circulating tumour DNA (ctDNA) is a promising biomarker for diffuse large B-cell lymphoma (DLBCL) risk stratification and treatment response assessment, but real-world studies were limited. Using a targeted sequencing approach (521-gene panel), we showed that (1) baseline ctDNA level correlated with tumour burden and was an independent predictor of treatment outcome, (2) achievement of minimal residual disease (MRD) negativity was associated with a better treatment outcome and (3) interim MRD-positivity combined with positron emission tomography/computed tomography scan-positivity identified a high-risk subgroup of DLBCL patients. Baseline ctDNA level and treatment related achievement of MRD negativity are valuable prognostic tools in DLBCL to improve risk stratification in routine clinical practice.
View Article and Find Full Text PDFJ Nucl Cardiol
September 2025
Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA. Electronic address:
Background: Cardiac positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are widely used for the assessment of coronary artery disease. While SPECT remains more available, workforce shortages and training demands contribute to geographic disparities in PET availability, impacting patient access to advanced imaging. Therefore, we assessed trends in the U.
View Article and Find Full Text PDFJ Nucl Cardiol
August 2025
Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA.
Systemic amyloidosis is a complex disorder, making early and accurate diagnosis challenging. The most common types are associated with misfolded transthyretin or immunoglobulin light chains, where cardiac and renal amyloidosis portend the worst prognosis. Peptide p5+14 can bind all types of amyloid via multivalent electrostatic interactions.
View Article and Find Full Text PDFJ Vasc Interv Radiol
September 2025
Interventional Radiology, University Hospital of Patras,Rio , Greece ,26504.
This study investigated the effects of Yttrium-90 (Y90) radioembolization in 8 rabbits, focusing on delivery accuracy, dosimetry, and pathological outcomes. Y90 was successfully delivered angiographically targeted via the pulmonary lower basal segmental arteries to all rabbits, with confirmation via PET/CT imaging and a lung target median of the mean dose 132.1Gy (range, 11.
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