A tale of two tracers - Amyloid imaging with investigational radiotracers iodine (I) evuzamitide and Tc-p5+14 (AT-05).

Systemic amyloidosis is a complex disorder, making early and accurate diagnosis challenging. The most common types are associated with misfolded transthyretin or immunoglobulin light chains, where cardiac and renal amyloidosis portend the worst prognosis. Peptide p5+14 can bind all types of amyloid via multivalent electrostatic interactions.

Analyzing point of care tools through faculty, resident, and stakeholder buy-in: promise and pitfalls.

Costs for UpToDate, the library's primary point of care clinical tool, had increased to half of the acquisitions budget but without user affiliation data to facilitate cost sharing. A working group led by librarians was formed to review alternatives. Surveys indicated users preferred UpToDate and renewal was recommended by the working group, with costs being shared between the academic unit and the hospital.

Systematic librarian-led zip code analysis to target underserved communities.

Background: To compare the library's health information service usage area and customer topics with the hospital's reasons for hospitalizations to examine commonalities and explore potential growth opportunities within the community.

Case Presentation: Researchers partnered with the hospital for this project. IRB approval was received.

Increase in Aortic Valve Mean Gradients One Day After Transcatheter Aortic Valve Implantation: The Role of Mitral Regurgitation.

Background: Following transcatheter aortic valve implantation (TAVI), transvalvular mean gradient is known to increase from immediate to 24 h post-procedure. While anesthesia, rapid-pacing, and volume status are blamed, the true etiology is unclear. To our knowledge, no prior studies have evaluated the effects of mitral regurgitation (MR) on the rise in post-TAVI transvalvular mean gradient.

Comparing robotic to open retromuscular ventral hernia repair: a multi-center propensity-matched analysis.

Introduction: Robotic retromuscular ventral hernia repair (r-RVHR) may benefit patients by converting an open surgery (o-RVHR) to a minimally invasive approach. Current comparative trials are limited by small patient cohorts and exploratory outcomes. This study compares short- and long-term outcomes of robotic versus open retromuscular ventral hernia repairs using a nationwide registry.

The effect of patient education on maternal fasting blood glucose in gestational diabetes mellitus in randomized controlled trials: a systematic review and meta-analysis.

Objective: To evaluate the effect of patient education interventions on fasting blood glucose (FBG) in patients with gestational diabetes mellitus (GDM).

Methods: Electronic search of MEDLINE/PubMed, CINAHL (EBSCO), Embase (Elsevier), Cochrane Central Register of Controlled Trials (CENTRAL), and Clinicaltrials.gov was conducted from inception to September 16, 2022.

Patient Educational Materials for Pheochromocytoma Exceed Recommended Readability Level: An Analysis Across Three Independent Reading Instruments.

Patient education is a critical component of effective medical care; > 50% of patients seek medical information from online sources. The recommended reading level is sixth grade. This study examines reading level of current online educational resources for patients with pheochromocytoma.

Patients Prefer Being Offered a Mirror to See Their Cervix and External Genitalia During Well-Exams while Clinician Perceptions May Create Barriers to Offering a Mirror: A Mixed Methods Study in a Primary Care Setting.

Objective: Patient-centered care is a core value of both Family Medicine and Obstetrics & Gynecology. We sought to know if patients prefer being offered a mirror to see their cervix and external genitalia during asymptomatic speculum exams (Mirror Pelvic Exam, MPE). Additionally, we explored clinicians' (medical assistants, residents, and faculty) opinions about offering patients a mirror during exams.

"Predicting Resection Weights of Reduction Mammaplasty: A Multi-Institutional Retrospective Analysis Using Machine Learning".

Background: A single-institution study performed by our authors demonstrated that machine learning (ML) utilizing preoperative anthropometric variables was an accurate alternative to the Schnur Scale in predicting resection weights during reduction mammaplasty (RM). We sought to evaluate ML and regression modeling in a heterogenous multi-institutional population for predicting RM resection weights with improved accuracy and generalizability.

Methods: A multi-institutional retrospective study was performed including 635 patients from three institutions who underwent RM for macromastia between 2017 and 2022.

Single-stage Segmental Tibial Defect Reconstruction With Double-barrel Free Fibula Flap and Intramedullary Nail: An Innovative Technique Facilitating Early Load Bearing.

The authors present a novel approach using a vascularized double-barrel fibula flap combined with an intramedullary nail (IMN) to reconstruct critical-size segmental tibial defects. Current methods, such as bone transport or induced membrane techniques, require multiple procedures and are associated with high complication rates and delayed load bearing. We present the case of a 44-year-old man with nonunion and chronic osteomyelitis of the left tibia, who underwent reconstruction with a contralateral double strut free fibula flap, placement of IMN, and cancellous bone grafting.

Prenatal Diagnosis Post-Dobbs in an Abortion-Banned State: A Retrospective Cohort Study.

After the Supreme Court decision in overturned , a complete abortion ban went into effect in Tennessee. Abortion restrictions may influence decisions regarding prenatal genetic screening and diagnostic testing; however, the exact impacts are unknown. We aimed to describe any differences in the method, timing, or indications for diagnostic genetic testing between patients presenting to a single regional referral site before and after the decision.

Comparison of open and laparo-endoscopic repair techniques for patients with bilateral inguinal hernias.

Introduction: For primary bilateral inguinal hernias, international guidelines favor a laparoscopic posterior mesh repair due to relatively lower risk of acute and chronic pain, faster recovery, and favorable biomechanical properties compared to open anterior approaches (Lichtenstein, plug and patch, etc.). However, studies comparing open mesh-based bilateral inguinal hernia repairs to bilateral laparoscopic and robotic mesh-based approaches are limited.

An Increase in Mean Aortic Valve Gradients the Day After Transcatheter Aortic Valve Implantation: The Effects of Evolving Anesthesia Techniques.

: After transcatheter aortic valve implantation (TAVI), transvalvular gradients increase immediately following the procedure up to 24 h afterward. While factors such as anesthesia type and fluid status have been suggested as potential contributors, the underlying cause remains unclear. With advancements in TAVI techniques, there has been a shift in anesthesia protocols from general anesthesia (GA) to monitored anesthesia care (MAC).

Understanding young adults' perceptions regarding human papillomavirus vaccination: A qualitative study.

Background: Over 47,000 human papillomavirus (HPV) related cancers are newly diagnosed every year in the United States, yet HPV vaccination rates are below desirable levels. Young adulthood is critical for catch-up HPV vaccination. Previous research on HPV vaccine-seeking behavior among young adults is limited, particularly in Tennessee.

Risk Stratification for Postoperative Opioid Induced Respiratory Depression: A Retrospective Case-Control Analysis of Existing Validated Tools.

Purpose: Postoperative opioid-induced respiratory depression (POIRD) is a preventable perioperative cause of morbidity and mortality. A validated POIRD risk stratification tool could reduce these complications. 3 pre-existing validated opioid tools; and specific risk factors identified from these tools; were examined in this retrospective case-control study to determine if they could assess POIRD risk in patients discharged to hospital floors from the Post-Anesthesia Care Unit (PACU).

Permanent Contraception: Epidemiology and Access.

This article will review the latest evidence about permanent contraception, discussing epidemiology, evidence for salpingectomy as a preferred method, timing of postpartum and interval, understanding of risk of regret, and continued barriers to access balanced against ongoing risks for coercion.

Gender Trends in Medical and Health Sciences Libraries, 2013-2024.

This column explores gender trends over the past decade in medical and health sciences libraries through data reported from the Association of Academic Health Sciences Libraries (AAHSL) and Association of Research Libraries' (ARL) salary surveys of their member institutions. Trends are related to gender composition and percentage of men in libraries are examined. Specifically, the column probes whether the gender composition in academic medical libraries has varied, whether the percentage of men in reporting libraries is increasing, and whether men are overrepresented in administrative positions.

Trends in Medical and Health Sciences Librarianship: A Comparative Analysis of Job Postings, Salary and Geographic Location, 2022 - 2024.

Job postings for medical and health sciences librarians provide valuable data for those seeking a better understanding of the evolving field of librarianship. Our data indicate a decrease in the number of postings from 2022 to 2024, a modest increase in the percentage of postings advertising remote/hybrid work, an increase in the average minimum posted salary, and a majority of postings focused on one or more public service components of library services. Utilizing this data provides a more complete picture of a profession in transition.

Oral microbiome and mycobiome dynamics in cancer therapy-induced oral mucositis.

Cancer therapy-induced oral mucositis is a frequent major oncological problem, secondary to cytotoxicity of chemo-radiation treatment. Oral mucositis commonly occurs 7-10 days after initiation of therapy; it is a dose-limiting side effect causing significant pain, eating difficulty, need for parenteral nutrition and a rise of infections. The pathobiology derives from complex interactions between the epithelial component, inflammation, and the oral microbiome.

3D-Printed Poly (Lactic-Co-Glycolic Acid) and Graphene Oxide Nerve Guidance Conduit with Mesenchymal Stem Cells for Effective Axon Regeneration in a Rat Sciatic Nerve Defect Model.

Introduction: Peripheral nerve injuries (PNIs) impact the quality of life of millions of people. The current gold standard of treatment, the autograft, fails to restore nerve function and is often associated with untoward effects. The alternative interventions available remain unable to ensure full functional recovery.

Outcomes of quadratus lumborum blocks for pain control after open abdominal wall reconstruction: a single institution retrospective analysis.

Introduction: Abdominal wall reconstruction (AWR) is associated with significant post-operative pain for which there is no standardized treatment regimen. Quadratus lumborum (QL) blocks have not been studied in open ventral hernia repair. This study reviews our institution's experience with QL blocks in open AWR.