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When walking freely, humans prefer maintaining a nearly constant walk ratio (WR) (step length/cadence). An unnatural WR requires greater metabolic energy expenditure, with mechanical power demands underlying the metabolic response. To investigate the effects of WR on the effectiveness of mechanical energy utilization during walking, this study compared the average total absolute mechanical power during the stance ( ) and swing ( ) phases between preferred and unnatural WRs at a fixed walking speed. Twenty healthy participants walked at their preferred WR and at six types of unnatural WRs at a preferred walking speed. The unnatural WRs comprised six cadence conditions (±10, ±15 and ±20 of preferred cadence). was significantly higher at high WRs (slower cadence) than at the preferred WR ( < 0.05) owing to an increased braking ground reaction force and shorter relative stance phase duration. was significantly higher at low WRs (faster cadence) than at the preferred WR ( < 0.05) owing to the hip and knee joint powers being applied strongly and synchronously to prevent excessive knee flexion and extension. The preferred WR can optimize the effectiveness of mechanical work production, which may help to minimize metabolic energy expenditure.
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http://dx.doi.org/10.1098/rsos.250740 | DOI Listing |
Foot Ankle Int
September 2025
Department of Radiology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.
Background: Coronal wedge insoles are commonly prescribed to mitigate musculoskeletal disorders, yet their static-standing kinematic and kinetic effects on lower extremity joints remain insufficiently understood.
Methods: This cross-sectional experimental study included 15 healthy older adults (mean 64.9 ± 6.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Rehabilitation Medicine, Second Xiangya Hospital, Central South University, Changsha 410011.
Objectives: Osteoarthritis (OA) is one of the most common chronic degenerative diseases, with chondrocyte apoptosis and extracellular matrix (ECM) degradation as the major pathological changes. The mechanical stimulation can attenuate chondrocyte apoptosis and promote ECM synthesis, but the underlying molecular mechanisms remain unclear. This study aims to investigate the role of primary cilia (PC) in mediating the effects of mechanical stimulation on OA progression.
View Article and Find Full Text PDFJ Exp Biol
September 2025
Department of Biomechanics, University of Nebraska at Omaha, Omaha, NE, USA.
Effective locomotion requires physiological systems to adapt to instabilities. While gait perturbation recovery often appears rapid, it is possible that longer-lasting effects may be present. Therefore, this study explored recovery trends of gait dynamics following an experimenter-induced perturbation.
View Article and Find Full Text PDFLab Chip
September 2025
Department of Mechanical Systems Engineering, Graduate School of Systems Design, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo, 192-0397, Japan.
Cell sorting is an important fundamental process for the selection and purification of target cell types for cell analysis in the life sciences and medical fields. In particular, demand is increasing for high-throughput cell sorting technology for the analysis of rare cells. Toward this end, we developed a centrifugal force-based cell sorting technique that relies on the adhesion force of cells as a marker.
View Article and Find Full Text PDFElectrophoresis
September 2025
School of Mechanical Engineering, Jiangsu Key Laboratory for Design and Manufacturing of Precision Medicine Equipment, Southeast University, Nanjing, China.
Electric droplet sorting is widely applied in the screening of target molecules, cells, drugs, and microparticles. Previous studies have made several optimizations on the electrode materials, structures, and arrangements. However, voltages of over 1 kV are required to realize droplet sorting, which causes the undesired droplet splitting.
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