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Patients with Fontan circulation are increasingly presenting for non-cardiac surgical procedures in adulthood, often involving complex anaesthetic management due to their unique physiology. We report the case of a 39-year-old Fontan patient who underwent elective thoracoscopic epicardial pacemaker lead revision under one-lung ventilation, requiring advanced hemodynamic monitoring, inotropic support, and pulmonary vasodilators. This case highlights the significant perioperative challenges in such patients and the need for a specialised, multidisciplinary team. In addition to this case, we reviewed previously published reports on one-lung ventilation in Fontan patients to provide a broader perspective on perioperative strategies and outcomes in this high-risk population.
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http://dx.doi.org/10.7759/cureus.89274 | DOI Listing |
NPJ Biol Phys Mech
September 2025
Department of Biomedical Engineering, Boston University, Boston, MA USA.
The lung undergoes continuous remodeling throughout normal development and aging, including changes to alveolar and capillary structure and function. While histological methods allow for static analysis of these age-related changes, characterizing the changes that occur in response to mechanical stimuli remains difficult, particularly over a dynamic, physiologically relevant range in a functioning lung. Alveolar and capillary distension - the change in diameter of alveoli and capillaries, respectively, in response to pressure changes - is one such process, where dynamically controlling and monitoring the diameter of the same capillary or alveolus is essential to inferring its mechanical properties.
View Article and Find Full Text PDFJ Physiol
September 2025
Institue for Exercise and Environmental Medicine, Texas Presbyterian Hospital, Dallas, TX, USA.
Some patients with heart failure with preserved ejection fraction (HFpEF) have demonstrated evidence of exercise-induced arterial hypoxaemia (EIAH). However, EIAH was not quantified using , , and measurements as previously conducted in healthy adults nor was EIAH quantified alongside simultaneous measurements of pulmonary vascular pressures, cardiorespiratory responses, or dyspnoea on exertion (DOE) in these patients. Given the effects of hypoxaemia on pulmonary vasoconstriction, cardiorespiratory responses, and DOE, we tested the hypothesis that patients with HFpEF and EIAH (EIAH) would demonstrate higher pulmonary vascular pressures, worse oxygen uptake, and greater DOE compared with patients without EIAH (EIAH).
View Article and Find Full Text PDFResuscitation
September 2025
Department of Pediatrics, Division of Neonatology, The Children's Hospital of Philadelphia and The University of Pennsylvania Perelman School of Medicine, Division of Neonatology, 2(nd) Floor, Main Building, 3401 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Aim: Flow disruptions (FDs) are deviations in the progression of care that compromise safety and efficiency of a specific process. Neonatal intubation is a life-saving high-risk procedure required for delivery room (DR) management of neonates with moderate to severe congenital diaphragmatic hernia (CDH). This study evaluated FDs during DR intubation of neonates with CDH and their association with process and outcome measures.
View Article and Find Full Text PDFJ Anesth
September 2025
Department of Anesthesiology, Dokkyo Medical University Saitama Medical Centre, 2-1-50, Minami-Koshigaya, Koshigaya, Saitama, 343-8555, Japan.