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National emissions targets are collectively insufficient to align with the Paris Agreement. The fair-share literature assesses whether these targets are fair and ambitious in comparison to emissions trajectories based on equity principles. Such emissions trajectories commonly start at present-day emissions levels. Here we show that these continuous trajectories inherently reward past inaction and increasingly do so with their iterative updates. We provide an approach to allocating emissions trajectories based on equity principles applied with immediate effect. The resulting discontinuous national trajectories not starting at current emissions levels imply significant immediate international support to fund rapid mitigation globally. Modelling allocations with or without continuity has remarkable consequences for the relative implied contributions to international support among high-income countries. We find that emissions targets of G7 countries, Russia and China are responsible for most of the global 2030 ambition gap, while only some countries align with their 1.5 °C allocation.
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http://dx.doi.org/10.1038/s41467-025-62947-9 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Department of Medicine, Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
The β-adrenergic receptor (βAR), a prototype G protein-coupled receptor, controls cardiopulmonary function underpinning O delivery. Abundance of the βAR is canonically regulated by G protein-coupled receptor kinases and β-arrestins, but neither controls constitutive receptor levels, which are dependent on ambient O. Basal βAR expression is instead regulated by the prolyl hydroxylase/pVHL-E3 ubiquitin ligase system, explaining O responsivity.
View Article and Find Full Text PDFGraefes Arch Clin Exp Ophthalmol
September 2025
Department of Physics of Condensed Matter, Optics Area. Vision Research Group (CIVIUS), University of Seville, Avenida de la Reina Mercedes s/n (41012), Seville, Spain.
Purpose: To analyze the relationship between various visual function parameters (refractive status, visual acuity and contrast sensitivity) and macular pigment optical density (MPOD) values, as well as dietary intake of lutein and zeaxanthin in a pediatric population.
Methods: Thirty-six healthy White pediatric patients participated in this cross-sectional study conducted at the Optometry Clinic (Faculty of Pharmacy, Seville, Spain). MPOD values were measured using the MPSII (Macular Pigment Screener II).
J Clin Nurs
September 2025
Teaching and Research Section of Clinical Nursing, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Background: Skin tone can affect clinical signs and device accuracy in paediatric anaemia and deterioration detection, creating risks of inequity.
Key Issues: Studies show disparities in diagnostic accuracy across different skin tones, supported by community-based evidence.
Recommendations: (1) Build multicenter networks with standardised skin-tone data.
Glob Health Action
December 2025
School of Public Health, Makerere University, Kampala, Uganda.
This Commentary is part of the Special Issue titled . The Issue examines the Global Financing Facility (GFF) through the lens of nine papers that explore the content and development processes of GFF country documents. While the GFF achieved technical alignment with national reproductive, maternal, newborn, child, and adolescent health priorities, it did not consistently translate into the mobilization of increased domestic resources.
View Article and Find Full Text PDFInquiry
September 2025
University of Southern California, Los Angeles, CA, USA.
Identifying low-cost implementation strategies to facilitate the uptake of technological innovations can help low-resource community clinics mitigate health disparities. Using a social network approach to identify organizational opinion leaders (OLs) can facilitate the adoption of innovations. To fill knowledge gaps related to alternative methods of identifying OLs, we identify and compare OLs in a low-resource community clinic using theoretically based techniques using Phi correlations and a binary logistic regression.
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