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A Practical Approach to the Diagnosis and Management of Hepatic Encephalopathy] Hepatic encephalopathy (HE) is a common complication of decompensated cirrhosis that can be reversed with treatment. Frequent episodes of recurrence are common, impacting patients, caregivers and healthcare systems, increasing morbidity and mortality statistics and resulting in grave financial consequences. Uptake and adherence to formal recommendations for HE diagnosis and management are low. There is an unmet need to advocate for the use of these recommendations in a more pragmatic form. Clinicians from multiple disciplines, dedicated to raising liver disease awareness, convened in a roundtable format to review and discuss the latest HE guidelines and relevant peer-reviewed literature on HE. The result was this clinical care publication on the screening, diagnosis and management of HE which seeks to facilitate clinicians' recognition and diagnosis of HE, apply a pathway of care for HE that addresses steps for initial management, long-term maintenance and prevention; it also addresses practical recommendations concerning situations encountered in HE. Resources are provided to address the different needs of the three key players in HE: patients, caregivers, and healthcare professionals. [Text for: A Practical Approach to the Diagnosis and Management of Hepatic Encephalopathy].
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http://dx.doi.org/10.1016/j.amjmed.2025.08.041 | DOI Listing |
Biomaterials
August 2025
Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address:
Wearable bioelectronics have transformed modern biomedical applications by enabling seamless integration with biological tissues, providing continuous, comprehensive, and personalized healthcare. Skin cancer, particularly melanoma, poses a significant clinical challenge due to its high metastatic potential and associated mortality. Traditional diagnostic approaches face limitations in accuracy, accessibility, and reproducibility, while existing treatments are often constrained by systemic toxicity and therapeutic resistance.
View Article and Find Full Text PDFTurk J Pediatr
September 2025
Division of Allergy and Asthma, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Animal allergens, particularly those from cats, dogs, and horses, are significant risk factors for the development of allergic diseases in childhood. Managing animal allergies requires allergen avoidance and, when this is not feasible, specific immunotherapy. Patient history remains the cornerstone of diagnosis, providing the foundation for diagnostic algorithms.
View Article and Find Full Text PDFTurk J Pediatr
September 2025
Department of Child and Adolescent Psychiatry, Ankara Bilkent City Hospital, Faculty of Medicine, Ankara Yıldırım Beyazıt University, Ankara, Türkiye.
Background: Intractable paroxysmal sneezing is a rare and diagnostically challenging condition in children, often mimicking organic diseases. While it is often addressed as psychogenic in the literature, our case presented findings suggestive of a tic disorder, highlighting the need for a broader diagnostic perspective.
Case Presentation: An 11-year-old girl was referred to the child and adolescent psychiatry clinic with a one-year history of persistent and fluctuating sneezing episodes.
Am J Clin Hypn
September 2025
Higher Institute of Nursing and Health Technology, Rabat, Morocco.
Gestational trophoblastic tumors (GTTs) encompass a spectrum of neoplastic conditions, including invasive mole, choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. Invasive mole, which frequently develops following a complete hydatidiform mole, represents the most common form. A cancer diagnosis constitutes a profoundly destabilizing experience, often resulting in considerable psychological distress.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
Department of Medical Oncology, Early Phase Unit, Georges-François Leclerc Centre, Dijon, France.
Background: Sarcomas are rare cancer with a heterogeneous group of tumors. They affect both genders across all age groups and present significant heterogeneity, with more than 70 histological subtypes. Despite tailored treatments, the high metastatic potential of sarcomas remains a major factor in poor patient survival, as metastasis is often the leading cause of death.
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