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Background: Approximately 60% of patients who have a stroke are discharged to their homes, after which they require ongoing community-based rehabilitation to support long-term recovery. Transitional care services (TCS) serve as an intervention aimed at reducing hospital readmissions by maintaining treatment continuity, either when patients transition between different levels of care within the same setting or when they move to a new care environment.
Objectives: The purpose of this review was to evaluate the efficacy of TCS in reducing readmission rates, enhancing functional outcomes, improving self-efficacy, and boosting the quality of life for patients who had a stroke while also alleviating caregiver burden.
Methods: To review randomized clinical trials performed between January 2014 and December 2023, we adhered to the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines for reporting systematic reviews. We established a search strategy combining "Transitional Care," "Stroke," "Cerebrovascular Disorders," "Patient Discharge," and "Continuity of Patient Care" and used the PubMed, Embase, Cochrane Library, and CINAHL databases. We selected readmission rate and functional status as the primary outcomes and quality of life, self-efficacy, and care burden as secondary outcomes. We conducted a meta-analysis for each outcome indicator where quantitative synthesis was possible. For the meta-analysis, we used RevMan 5.4 and performed subgroup analyses according to intervention intensity, post-discharge intervention method, and intervention duration.
Results: In the meta-analysis for each outcome indicator, we observed that TCS was effective in reducing the readmission rate of individuals living with stroke and improving their functional status. Additionally, patients with stroke who received TCS showed better quality of life, improved self-efficacy, and reduced caregiver burden compared to those who received usual care. Subgroup analyses revealed that patients with stroke who received moderate or higher intensity TCS for 2 months demonstrated improvements in functional status compared to those who received lower intensity or 3-month interventions.
Discussion: This is the first known systematic review to synthesize studies on the efficacy of TCS for patients with stroke over the past 10 years, examining outcome indicators such as readmission rates and functional status. Based on subgroup analysis, we derived an effective TCS strategy (e.g., intensity and duration) to improve functional status.
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http://dx.doi.org/10.1097/NNR.0000000000000858 | DOI Listing |
PLoS Comput Biol
September 2025
Department of Mathematical and Computational Methods, National Laboratory for Scientific Computing, Petrópolis, Brazil.
Understanding cerebral circulation is crucial for early diagnosis and patient-oriented therapies for brain conditions. However, blood flow simulations at the organ scale have been limited. This work introduces a framework for modeling extensive vascular networks in the human cerebral cortex and conducting pulsatile blood flow simulations.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Paul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, Colorado, United States of America.
Deciphering the source of an embolism is a common challenge encountered in stroke treatment. Carotid stenosis is a key source of embolic strokes. Carotid interventions can be indicated when a patient has greater than 50% stenosis in the carotid ipsilateral to the cerebral infarction, which is designated as the symptomatic carotid.
View Article and Find Full Text PDFJ Neurosurg Anesthesiol
October 2025
Department of Anesthesia and Perioperative Medicine, Western University.
Introduction: Current commercial cerebral oximeters only monitor the frontal lobes, however, some cerebrovascular territories may experience ischemia while others remain well perfused. This pilot study used a novel, high-density, dual-wavelength, time-resolved functional cerebral oximeter (Kernel Flow) with 2000 channels to assess the regional differences of cerebral oxygenation (StO2) in response to hypotension across different vascular territories during shoulder surgery in the beach chair position.
Methods: Twenty-seven adult patients were monitored, recording blood pressure, heart rate, regional cerebral oxygen saturation, and other vital parameters.
JAMA Netw Open
September 2025
Division of Cardiology, Department of Internal Medicine, New Taipei Municipal TuCheng Hospital, New Taipei, Taiwan.
Importance: The cardiovascular benefits of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may vary by body mass index (BMI), but evidence on BMI-specific outcomes remains limited.
Objective: To investigate the associations of GLP-1 RA use with cardiovascular and kidney outcomes across BMI categories in patients with type 2 diabetes.
Design, Setting, And Participants: This retrospective cohort study used the Chang Gung Research Database, a clinical dataset covering multiple hospitals in Taiwan.
Neurol Sci
September 2025
School of Public Health, Shaanxi University of Chinese Medicine, Shaanxi, 712046, Xianyang, P. R. China.
Background: Stroke persists as the second leading global cause of mortality and disability. We analyzed G20 nations using Global Burden of Disease (GBD) 2021 data (1990-2021) to provide a new perspective.
Methods: We obtained age-standardized rates (ASR) of stroke mortality, incidence, prevalence, and YLLs (years of life lost) across G20 nations.