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With the widespread adoption of internet technologies and email communication systems, the exponential growth in email usage has precipitated a corresponding surge in spam proliferation. These unsolicited messages not only consume users' valuable time through information overload but also pose significant cybersecurity threats through malware distribution and phishing schemes, thereby jeopardizing both digital security and user experience. This emerging challenge underscores the critical importance of developing effective spam detection mechanisms as a cornerstone of modern cybersecurity infrastructure. Through empirical analysis of machine learning (ML) performance on publicly available spam datasets, we established that algorithmic ensemble methods consistently outperform individual models in detection accuracy. We propose an optimized stacking ensemble framework that strategically combines predictions from four heterogeneous base models (NBC, k-NN, LR, XGBoost) through meta-learner integration. Our methodology incorporates grid search cross-validation with hyperparameter space optimization, enabling systematic identification of parameter configurations that maximize detection performance. The enhanced model was rigorously evaluated using comprehensive metrics including accuracy (99.79%), precision, recall, and F1-score, demonstrating statistically significant improvements over both baseline models and existing solutions documented in the literature.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407460 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0331574 | PLOS |
With the widespread adoption of internet technologies and email communication systems, the exponential growth in email usage has precipitated a corresponding surge in spam proliferation. These unsolicited messages not only consume users' valuable time through information overload but also pose significant cybersecurity threats through malware distribution and phishing schemes, thereby jeopardizing both digital security and user experience. This emerging challenge underscores the critical importance of developing effective spam detection mechanisms as a cornerstone of modern cybersecurity infrastructure.
View Article and Find Full Text PDFA A Pract
August 2025
From the Centre for Journalology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Eur J Intern Med
August 2025
Department of Tourism and Hospitality, Faculty of Economics and Business, John von Neumann University, Kecskemét, Hungary; Department of Tourism and Hospitality, Institute of Rural Development and Sustainable Economy, Hungarian University of Agriculture and Life Sciences (MATE), Gödöllő, Hungary
The rise of questionable journals poses a significant threat to academic integrity, resulting in substantial waste of institutional and university resources. This commentary analysis focuses on six hijacked medical journals, a specific type of questionable publication. We utilized Semrush, an online Search Engine Optimization auditing platform, to analyse our data, which revealed that hijacked journals disseminate their content through search engines.
View Article and Find Full Text PDFClin Chim Acta
August 2025
NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou 510060, China; Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou 510632, China. Electronic
The irreversibility and lethality of Spinal Muscular Atrophy (SMA) underscore the urgency of newborn screening, as diagnostic delay in neonates causes irreversible motor neuron degeneration and poor outcomes. Current SMA detection methods are hindered by high costs, dependence on specialized equipment, and technical complexity, restricting their implementation in primary care setting. Here, we proposed a fast and sensitive SMA-(Recombinase Polymerase Amplification) RPA-Cas12a detection assay based on suboptimal protospacer adjacent motif (sPAM) and 3'-end ssDNA-modified crRNA, named SPSMC.
View Article and Find Full Text PDFJAMIA Open
June 2025
GenOmics and Translational Research Center, RTI International, Research Triangle Park, NC 27709-2194, United States.
Objective: Electronic patient portals (PP) allow for targeted and efficient research recruitment. We assessed pre- and postnatal women's recruitment methods preferences, focusing on PP.
Materials And Methods: We conducted 4 in-person focus groups with new and expecting mothers.