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http://dx.doi.org/10.1186/s13613-025-01553-w | DOI Listing |
J Am Chem Soc
September 2025
Department of Chemistry, National Taiwan University, Taipei 106319, Taiwan.
The exclusive formation of artificial multicomponent assemblies remains a significant challenge, in contrast to the well-established organization observed in natural systems, due to intrinsic entropic constraints. To overcome this limitation, recent efforts have been focused on developing precision self-assembly strategies for the rational construction of such architectures. Here, we construct an ideal complementary pair of 2,2':6',2″-terpyridine (tpy)-based ligands by fine-tuning the substituent bulkiness, which enables the quantitative formation of robust nested cages through efficient dynamic heteroleptic complexation with multivalent coordination.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Graduate School of Frontier Sciences, The University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8568, Japan.
Chemical sensor arrays mimic the mammalian olfactory system to achieve artificial olfaction, and receptor materials resembling olfactory receptors are being actively developed. To realize practical artificial olfaction, it is essential to provide guidelines for developing effective receptor materials based on the structure-activity relationship. In this study, we demonstrated the visualization of the relationship between sensing signal features and odorant molecular features using an explainable AI (XAI) technique.
View Article and Find Full Text PDFDiabetes Metab Syndr Obes
September 2025
Medical School, Kunming University of Science and Technology, Kunming, People's Republic of China.
Diabetes has emerged as a critical global health issue, with its associated complications posing a severe threat to patients' quality of life. Current research demonstrates that imbalance in mitochondrial dynamics and autophagic dysregulation play pivotal roles in the pathogenesis of diabetic complications, particularly in diabetic cardiomyopathy, nephropathy, peripheral neuropathy and retinopathy. Strategic modulation of mitochondrial function and autophagic activity represents a promising therapeutic approach for managing diabetic complications.
View Article and Find Full Text PDFPerspect Behav Sci
September 2025
Institute for Applied Behavioral Science, Endicott College, Beverly, MA USA.
Ethics is fundamentally concerned with claims of "right," "wrong," "good," "bad," and how we might know those claims are accurate. Artificial intelligence (AI) is a term that represents a suite of tools where nonbiological systems process data and information to generate an output considered "intelligent." As with any suite of technologies, choosing the right tool requires the tool user to critically evaluate which tool is best for the task (if one exists).
View Article and Find Full Text PDFNeurotrauma Rep
April 2025
Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada.
For nearly 350 years, the process of disseminating scientific knowledge has remained largely unchanged. Scientists conduct experiments, analyze the data, and publish their findings in the form of scientific articles. Since the turn of the century, this process has been challenged by numerous open science and data sharing efforts to enhance transparency, reproducibility, and replicability of scientific research.
View Article and Find Full Text PDF