98%
921
2 minutes
20
Introduction: The Medical Informatics Initiative (MII) aims to enable cross-site secondary use of clinical data in Germany using a FHIR-based Core Data Set (CDS). However, current FHIR Implementation Guides (IG) often lack actor-specific guidance, leading to inconsistent interpretations and implementations.
Methods: This technical case report explores the use of FHIR Implementation Obligations to clarify responsibilities and expected system behavior within the MII infrastructure. Obligations were modeled using the FHIR obligation extension and ActorDefinition resources, applied to the Patient profile from the CDS Person module. A prototype IG was generated using the HL7 FHIR IG publisher tooling.
Results: Obligations were defined and rendered for multiple actors - such as Data Integration Centers (DIC) and the Health Research Data Portal (FDPG) - across selected Patient profile elements. Obligations were also linked to specific operations, enabling precise workflow targeting. The implementation improved the explicitness of responsibilities that were previously only implied.
Discussion: The study demonstrates that obligations enhance the clarity of FHIR IGs. However, limitations remain: the MII's current IG tooling does not yet support obligations, and conformance testing was not addressed. Further work is needed to standardize ActorDefinition resources, align obligations across modules, and develop validation tooling to realize the full potential of obligation-driven specifications.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.3233/SHTI251401 | DOI Listing |
PLoS One
September 2025
Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Volumetric modulated arc therapy (VMAT) for lung cancer involves complex multileaf collimator (MLC) motion, which increases sensitivity to interplay effects with tumour motion. Current dynamic conformal arc methods address this issue but may limit the achievable dose distribution optimisation compared with standard VMAT. This study examined the clinical utility of a VMAT technique with monitor unit limits (VMATliMU) to mimic conformal arc delivery and reduce interplay effects while maintaining plan quality.
View Article and Find Full Text PDFPLoS One
September 2025
Department Chemicals and Product Safety, German Federal Institute for Risk Assessment (BfR), Berlin, Germany.
Tattoos and permanent make-up (PMU) gain increasing popularity among the general population. There are indications that pigments or their fragments may translocate within the body, however knowledge about possible systemic adverse effects related to tattoos is very limited. We investigated the prevalence of systemic chronic health effects including cardiovascular diseases, cancer and liver toxicity and their relationship with the presence and characteristics of tattoos and PMU as part of the LIFE-Adult-study, a population-based cohort study.
View Article and Find Full Text PDFPsychother Psychosom
September 2025
Division of Endocrinology and Diabetology, Department of Internal Medicine, Interdisciplinary Metabolic Medicine Trials Unit, Medical University of Graz, Graz, Austria.
Introduction: Understanding chronic stress as a potential risk factor for COVID-19 progression could inform public health measures and personalized preventive interventions. Therefore, we investigated the influence of chronic stress prior to SARS-CoV-2 infection on symptom persistence 1 month after COVID-19 onset.
Methods: The participants of this prospective cohort study named "StressLoC" were adults with COVID-19 who had tested positive for SARS-CoV-2 infection within the last 7 days.
ACS Chem Neurosci
September 2025
Department of Medical Biology, Faculty of Medicine, Bahçeşehir University, Istanbul 34353, Turkey.
IL-17A is a pro-inflammatory cytokine that significantly contributes to the pathogenesis of autoimmune diseases, including multiple sclerosis (MS). Previous studies have suggested that PARP-1 inhibitors can modulate IL-17A-mediated inflammation, prompting the investigation of Niraparib, an FDA-approved PARP-1 inhibitor, as a potential therapeutic agent for MS. In this study, we hypothesized that Niraparib could disrupt the interaction between IL-17A and its receptor, IL-17RA.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Perelman School of Medicine, University of Pennsylvania, Philadelphia.
Importance: As obesity rates rise in the US, managing associated metabolic comorbidities presents a growing burden to the health care system. While bariatric surgery has shown promise in mitigating established metabolic conditions, no large studies have quantified the risk of developing major obesity-related comorbidities after bariatric surgery.
Objective: To identify common metabolic phenotypes for patients eligible for bariatric surgery and to estimate crude and adjusted incidence rates of additional metabolic comorbidities associated with bariatric surgery compared with weight management program (WMP) alone.