The Use of Etanercept in the Palliative Treatment of a Patient With Generalised Bullous Fixed Drug Eruption.

Australas J Dermatol

Department of Dermatology, The Canberra Hospital, Canberra Health Services, ACT, Canberra, Australia.

Published: September 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Generalised Bullous Fixed Drug Eruption (GBFDE) is a subtype of Fixed Drug Eruption (FDE) characterised by the development of generalised blisters on the background of dusky macules. There is no gold standard treatment, but the condition is conventionally managed with supportive care, topical and oral steroids and occasionally ciclosporin. We describe the case of a 75-year-old female with GBFDE, who demonstrated a rapid halt in disease progression and re-epithelialisation following a single dose of etanercept. This case highlights the potential role of etanercept in the management of GBFDE.

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajd.14577DOI Listing

Publication Analysis

Top Keywords

fixed drug
12
drug eruption
12
generalised bullous
8
bullous fixed
8
etanercept palliative
4
palliative treatment
4
treatment patient
4
patient generalised
4
eruption generalised
4
eruption gbfde
4

Similar Publications

Cadmium (Cad) is a worldwide heavy metal pollutant associated with global health challenges. Alteration of the intestinal microbiome, due to chemicals' exposure, plays a vital role in the pathogenesis of gastrointestinal diseases such as pancreatic disorders. Hence, modulation of the gut microbiota might be a targeted approach to manage pancreatic diseases.

View Article and Find Full Text PDF

Heart failure (HF) remains a global health challenge that imposes significant clinical and economic burden. Treatment adherence to guideline-directed medical therapy (GDMT) remains a major challenge in the management of HF, despite the availability of guideline-directed medical therapy (GDMT). Polypharmacy and regimen complexity contribute to poor adherence, particularly among older adults and in resource-limited settings.

View Article and Find Full Text PDF

Droplet splitting plays an important role in droplet microfluidics by providing precise control over droplet size, which is essential for applications such as single-cell analysis, biochemical reactions, and the fabrication of micro- and nanosized material. Conventional methods of droplet splitting using obstructions or junctions in the microchannel have a clear limitation that the split ratio for a particular device remains fixed, while existing active splitting methods are constrained by low flow rates, the need for complex systems, or limitations to specific droplet types. In this study, we demonstrate that droplet splitting can be achieved simply using a one-dimensional standing-wave field excited within a microchannel.

View Article and Find Full Text PDF

Kryptoperidinium belongs to a group of dinophytes hosting a diatom as an endosymbiont and is currently considered to comprise a single, putatively bloom-forming and harmful species only. Molecular phylogenetics indicate the existence of a second distinct lineage and therefore species new to science, which we here formally describe as Kryptoperidinium secundum sp. nov.

View Article and Find Full Text PDF

Cardiovascular disease remains the leading cause of morbidity and mortality among older adults, who often face unique challenges in preventive care due to multimorbidity, frailty, and polypharmacy. The polypill, a fixed-dose combination of multiple cardiovascular medications, has emerged as a promising strategy to improve adherence, simplify treatment, and reduce the burden of major cardiovascular events. This review aims to synthesize current evidence supporting polypill use in both primary and secondary prevention, with a particular focus on older populations.

View Article and Find Full Text PDF