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http://dx.doi.org/10.55563/clinexprheumatol/vxe3tj | DOI Listing |
Lancet Oncol
September 2025
Department of Cancer Medicine, Gustave Roussy, Paris-Saclay University, Villejuif, France.
Background: No standard treatment exists for patients with platinum-refractory advanced type B3 thymoma and thymic carcinoma. In the PECATI trial, we sought to assess the antitumour activity and safety of lenvatinib plus pembrolizumab in this population.
Methods: In this single-arm phase 2 trial, we recruited participants from 11 hospitals in France, Italy, and Spain.
Clin Exp Rheumatol
September 2025
Department of Internal Medicine, Edouard Herriot Hospital, Lyon University Hospital, Lyon, France.
Cancer Lett
August 2025
Department of Colorectal Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Engineering Research Center of Colorectal Cancer Minimally Invasive Technology, Shanghai, China. Electronic address:
Locally advanced rectal cancer (LARC) remains challenging to treat due to high recurrence rates and limited therapeutic options, particularly for patients with high-risk features. This prospective, multicenter, single-arm, open-label phase 2 trial (ClinicalTrials.gov identifier: NCT05300269) evaluated the efficacy and safety of SHR-1701, a novel bifunctional fusion protein targeting both PD-L1 and TGF-β, in combination with neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME) for high-risk LARC.
View Article and Find Full Text PDFInt J Emerg Med
August 2025
Department of Emergency Medicine, Riverside University Health System, Cactus Avenue, Moreno Valley, CA, 26520, USA.
Background: Systemic lupus erythematosus is an autoimmune inflammatory disease with extremely variable presentations. While a facial rash is the most common finding, other symptoms can include arthralgias, fatigue, and cytopenias. Abdominal symptoms are much less common presentations of lupus.
View Article and Find Full Text PDFInt J Artif Organs
August 2025
Hero DMC Heart Institute, Ludhiana, Punjab, India.
Forty five years morbidly obese male with prosthetic mitral and aortic valve referred to our hospital with dengue shock syndrome. He had recurrent ventricular arrhythmias required multiple shock and short cycle of cardiopulmonary resuscitation (CPR). He was supported with high dose vasopressors and mechanical ventilation.
View Article and Find Full Text PDF