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In 2018, we shortened the fasting time in our clinic for clear fluid to 1 h. Since 2021 'drinking until call to the operating theatre' applies. This quality assurance study investigates whether this regulation has further shortened the fasting times and which factors influence its implementation.In this prospective observational study, a two-part anonymous questionnaire from the attending anaesthetist and the parents was completed.A total of 204 children were included in the study. The fasting time for clear fluid (median [IQR] (min-max)) was 2 [1-4.6] (0.33-22) hours and was shorter than 3 [2-7.8] (0.5-17) hours in the pre-transition period. More than 50% of the children had access to clear fluid directly at the bedside or freely available on the ward. The children's drinking behaviour showed that 54% of the children drank on their own and only 4% of the children complained of thirst. When comparing the wards there were differences with regard to the fasting time for clear fluid. There were no differences in the fasting times depending on the operating theatre position. The length of time between the informed consent consultation and anaesthesia or language barriers had a negative influence on adherence to the fasting rules.Two years after the introduction of the 'sip til send' rule there was a significant reduction in fasting times. Fasting times did not differ between operating theatre position.
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http://dx.doi.org/10.1055/a-2638-9051 | DOI Listing |
Int J Pharm
September 2025
Life Quality (LQ) Engineering Interest Group, School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu Province 215123, China. Electronic address:
Gastrointestinal (GI) physiological variability significantly influences dissolution and bioavailability of non-disintegrating solid drug systems. This study employed the dynamic human stomach-intestine (DHSI-IV, branded as NERDT) system to characterize how gastric emptying kinetics and intestinal environmental dynamics affect drug release, using extended-release metformin matrix tablets (Glucophage XR®) and metformin osmotic pump tablets (Nida®) as model formulations. The DHSI-IV (NERDT) system accurately simulated three fasting-state gastric emptying profiles (30-120 min complete emptying) with excellent fit to the modified Elashoff model (R = 0.
View Article and Find Full Text PDFDiabetes Res Clin Pract
September 2025
Siriraj Population Health and Nutrition Research Group (SPHERE), Research Group and Research Network Division, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. Electronic address:
Aims: Low-carbohydrate diets (LCDs) have emerged as a potential dietary intervention for managing glycemic control, but their effectiveness across different cultural contexts remains unclear. To evaluate the efficacy of LCDs in managing type 2 diabetes, with attention to cultural context, and to clarify how variability in carbohydrate definitions affects interpretation.
Methods: We searched PubMed, Embase, and Scopus from inception to 1 August 2024 for randomized controlled trials (RCTs) ≥ 12 weeks in adults with type 2 diabetes.
PLoS One
September 2025
Department of Anatomy and Physiology, The University of Melbourne, Parkville, Victoria, Australia.
Food intake is a key regulator of the digestive system function; however, little is known about organ- and sex-specific differences in food-driven regulation. We placed male and female C57Bl/6 mice on time-restricted feeding (TRF), limiting access to food to an 8-hour window. Food was added either at dark (ZT12) or light (ZT0) onset for 14 days.
View Article and Find Full Text PDFPLoS One
September 2025
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background: The prevalence of Metabolic Syndrome (MetS) increases with aging, significantly contributing to the rising burden of non-communicable diseases (NCDs). This study aimed to investigate over-time changes in the prevalence of MetS and its components among the elderly population of Iran.
Methods: We analyzed data from the 2016 and 2021 national STEPwise approach to non-communicable disease risk factor Surveillance (STEPS) for participants aged ≥65 who completed all three survey steps (questionnaire-based assessments, physical measurements, and laboratory tests) with no missing data on MetS components.