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Does ionising radiation increase the risk of cancer even at low doses? If so, what is the magnitude of risk at these low doses? This knowledge is a central component of radiation protection. In general, radiation protection relies on the linear no-threshold (LNT) model, which is based on scientific findings. According to the LNT model, the radiation-related risk of cancer decreases proportionally with radiation dose and this applies even down to very low radiation doses. The model provides a straightforward and practical description of the relationship between a radiation dose and the resulting risk of cancer. These assumptions align with the latest radiobiological and radiation epidemiological findings. Therefore, and because of its simplicity, the model is used in radiation protection (e.g. for setting dose limits). The LNT model offers a plausible basis for prudent decision- making in radiation protection. However, it does not represent a universally valid description of the relationship between ionising radiation and specific biological mechanisms of carcinogenesis. This memorandum summarises the position of the Federal Office for Radiation Protection, Germany, on the use of the LNT model in radiation protection.
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http://dx.doi.org/10.1088/1361-6498/ae0136 | DOI Listing |
Glob Chang Biol
September 2025
Chair of Silviculture, Faculty of Environment and Natural Resources, Institute of Forest Sciences, University of Freiburg, Freiburg, Germany.
Mixed-species forests are proposed to enhance tree resistance and resilience to drought. However, growing evidence shows that tree species richness does not consistently improve tree growth responses to drought. The underlying mechanisms remain uncertain, especially under unprecedented multiyear droughts.
View Article and Find Full Text PDFFront Bioeng Biotechnol
August 2025
Navy Special Medical Centre, Second Military Medical University, Shanghai, China.
Radiation exposure initiates a cascade of reactions, including the release of reactive oxygen species, DNA double-strand breaks, and cellular apoptosis, leading to cell death, tissue damage, and potentially the development of cancer. Consequently, there is an urgent need to develop highly effective and low-toxicity radioprotective agents. Traditional chemically synthesized protective agents face significant limitations in clinical applicability due to their pronounced off-target toxicity, narrow therapeutic window, and high production costs.
View Article and Find Full Text PDFJ Nucl Med Technol
September 2025
Medical Physics Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
The glomerular filtration rate (GFR) is a key measure of renal function, typically estimated using creatinine-based equations. More precise clearance measurements are obtained with radiotracers, such as [Tc]Tc-diethylenetriaminepentaacetic acid (DTPA), and blood samples over several hours. However, standard plasma clearance methods require labor-intensive plasma preparation, limiting efficiency in clinical practice.
View Article and Find Full Text PDFAppl Radiat Isot
August 2025
Department of Physics, St.Joseph's College (Autonomous), Affiliated To Bharathidasan University, Tiruchirappalli 620 002, TamilNadu, India.
textcolorred This study reports the green synthesis, characterization, and radiation shielding performance of BaOBiO nanocomposites using Euphorbia tirucalli latex as a reducing agent. Structural analysis via PXRD confirmed distinct crystalline phases, and SEM revealed agglomerated nanoparticles below 500 nm. The UV-Vis spectra showed a wide optical bandgap of 3.
View Article and Find Full Text PDFJ Radiol Prot
September 2025
Centre for Radiation Protection Research, Stockholm University, Svante Arrheniusväg 20C, 106 91 Stockholm, Sweden.
The System of Radiological Protection (the "System") developed by the International Commission on Radiological Protection (ICRP) is built on nearly a century of efforts of numerous scientists and practitioners working together internationally. It rests on three enduring pillars: science, ethics, and experience. These pillars support the three fundamental principles that shape radiological protection strategies: justification, optimisation, and application of dose limits.
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