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http://dx.doi.org/10.1002/epd2.70100 | DOI Listing |
Neurol Sci
September 2025
Pediatric Neurosurgery Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Background: super-refractory status epilepticus (SRSE) is a rare and severe neurological condition associated with high mortality and significant long-term morbidity. In many cases, conventional medical treatments prove ineffective, with wide use of off-label therapies.
Methods: two researchers conducted a review of the medical records of subjects who had undergone VNS implantation in our tertiary Centre.
Epileptic Disord
September 2025
APHM, Timone Hospital, Epileptology and Cerebral Rhythmology, Marseille, France.
This case study reports the first documented use of stereoelectroencephalography (SEEG)-guided radiofrequency thermocoagulation (RFTC) to treat refractory status epilepticus (RSE). A 33-year-old woman with drug-resistant epilepsy and recurrent RSE underwent SEEG to define her epileptogenic zone. A new RSE started shortly before and continued during the SEEG exploration, being unresponsive to multiple antiseizure medications, vagal nerve stimulation, and corticosteroid therapy.
View Article and Find Full Text PDFEpilepsy Behav
September 2025
Danone Research & Innovation, Uppsalalaan 12, 3584 CT Utrecht, the Netherlands. Electronic address:
Purpose: Ketogenic diet therapy (KDT) has been successfully used as an effective management option for drug resistant epilepsy (DRE) since the 1920 s. The ketogenic formulation studied here (KetoCal) is nutritionally complete, very high in fat, and low in carbohydrates and has played a crucial role in supporting the implementation of KDT for over twenty-five years. This scoping review aims to synthesise the existing literature regarding the safety, acceptability, and efficacy of the ketogenic formulation in supporting the management of DRE.
View Article and Find Full Text PDFSeizure
August 2025
Serviço de Neurologia, Departamento de Neurociências e Saúde Mental, Hospital Santa Maria, Unidade Local de Saúde Santa Maria, Lisboa, Portugal; Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal; Laboratório de EEG/Sono, Serviço de Neurologi
Introduction: Subtle involuntary movements in patients with impaired awareness may suggest non-convulsive status epilepticus (NCSE), but their diagnostic accuracy is unclear. Since electroencephalography (EEG) is not always available, clinicians often rely on motor signs for early diagnosis. We aimed to characterize these movements and evaluate interrater agreement and diagnostic accuracy among specialists.
View Article and Find Full Text PDFNeurology
October 2025
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
Objectives: Status epilepticus (SE) is a life-threatening neurologic emergency. Although health disparities in epilepsy are well-documented, disparities in SE mortality are not fully understood. This study analyzes mortality trends and demographics in the United States from 1999 through 2020.
View Article and Find Full Text PDF