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http://dx.doi.org/10.55633/s3me/029.2025 | DOI Listing |
Alzheimers Dement
September 2025
Department of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Cognitive impairment and dementia, including Alzheimer's disease (AD), pose a global health crisis, necessitating non-invasive biomarkers for early detection. This review highlights the retina, an accessible extension of the central nervous system (CNS), as a window to cerebral pathology through structural, functional, and molecular alterations. By synthesizing interdisciplinary evidence, we identify retinal biomarkers as promising tools for early diagnosis and risk stratification.
View Article and Find Full Text PDFPediatr Transplant
November 2025
Division of Urology, University of Toronto, Toronto, Canada.
Introduction: Differentiating acute tubular necrosis (ATN) from rejection in pediatric kidney transplant (KT) recipients remains challenging and necessitates invasive biopsy. Doppler ultrasound-derived resistive index (RI) is a noninvasive modality to assess graft status, but its diagnostic utility in children is unclear. This study evaluates RI's ability to distinguish ATN and rejection in KT.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
School of Applied Sciences and Technology, Gujarat Technological University, Gujarat, India. Electronic address:
This chapter examines advancements and future trajectories in wearable biosensing technologies, a multidisciplinary field encompassing healthcare, materials science, and information technology. Wearable biosensors are revolutionizing real-time physiological and biochemical monitoring with applications in personalized health monitoring, disease diagnosis, fitness, and therapeutic interventions. In addition to Internet of Things (IoT) and wireless connectivity technologies such as Bluetooth Low Energy (BLE) and 5G, which facilitate transparent remote monitoring and data exchange, other notable innovations such as machine learning and artificial intelligence enhance real-time processing of data, predictive analytics, and personalized healthcare solutions.
View Article and Find Full Text PDFProg Mol Biol Transl Sci
September 2025
Heidelberg Institute of Global Health (HIGH), Faculty of Medicine and University Hospital, Heidelberg University, Heidelberg, Germany. Electronic address:
Climate change poses a growing threat to human health, increasing exposure to extreme environmental conditions. Wearable biosensors provide real-time monitoring of physiological responses to heat stress, including cardiovascular strain, thermoregulatory disruptions, sleep disturbances, and biomarkers of heat-related illnesses. These devices also assess behavioural adaptations, such as reduced physical activity, offering insights into physiological resilience and susceptibility.
View Article and Find Full Text PDFFront Neurol
August 2025
Department of Neurology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Introduction: Reperfusion failure (RF) describes a condition in which patients suffering a large vessel occlusion (LVO) stroke present insufficient tissue reperfusion and recovery despite optimal mechanical thrombectomy (MT) results. Approximately 50% of patients suffering from LVO are affected. Our current understanding of the underlying pathomechanisms is limited and mostly based on rodent models.
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